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Title: Acridine-intercalator based hypoxia selective cytotoxins

Abstract

Hypoxia selective cytotoxins of the general formula STR1 wherein n is from 1 to 5, and NO[sub 2] is in at least one of the 2, 4 or 5-positions of the imidazole are developed. Such compounds have utility as radiosensitizers and chemosensitizers. 9 figs.

Inventors:
;
Issue Date:
OSTI Identifier:
5026223
Patent Number(s):
5294715 A
Application Number:
PPN: US 7-649703
Assignee:
Univ. of Pittsburgh, Pittsburgh, PA (United States) PTO; EDB-94-077749
DOE Contract Number:  
FG02-89ER60869
Resource Type:
Patent
Resource Relation:
Patent File Date: 1 Feb 1991
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 62 RADIOLOGY AND NUCLEAR MEDICINE; ANTIMITOTIC DRUGS; CHEMICAL PREPARATION; ACRIDINES; ANOXIA; RADIOSENSITIVITY EFFECTS; RADIOSENSITIZERS; RESPONSE MODIFYING FACTORS; AROMATICS; AZAARENES; AZINES; DRUGS; HETEROCYCLIC COMPOUNDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PYRIDINES; SYNTHESIS; 560300* - Chemicals Metabolism & Toxicology; 550604 - Medicine- Unsealed Radionuclides in Therapy- (1980-)

Citation Formats

Papadopoulou-Rosenzweig, M., and Bloomer, W.D. Acridine-intercalator based hypoxia selective cytotoxins. United States: N. p., 1994. Web.
Papadopoulou-Rosenzweig, M., & Bloomer, W.D. Acridine-intercalator based hypoxia selective cytotoxins. United States.
Papadopoulou-Rosenzweig, M., and Bloomer, W.D. Tue . "Acridine-intercalator based hypoxia selective cytotoxins". United States.
@article{osti_5026223,
title = {Acridine-intercalator based hypoxia selective cytotoxins},
author = {Papadopoulou-Rosenzweig, M. and Bloomer, W.D.},
abstractNote = {Hypoxia selective cytotoxins of the general formula STR1 wherein n is from 1 to 5, and NO[sub 2] is in at least one of the 2, 4 or 5-positions of the imidazole are developed. Such compounds have utility as radiosensitizers and chemosensitizers. 9 figs.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1994},
month = {3}
}