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Title: Raman-based system for DNA sequencing-mapping and other separations

Abstract

DNA sequencing and mapping are performed by using a Raman spectrometer with a surface enhanced Raman scattering (SERS) substrate to enhance the Raman signal. A SERS label is attached to a DNA fragment and then analyzed with the Raman spectrometer to identify the DNA fragment according to characteristics of the Raman spectrum generated. 11 figures.

Inventors:
Issue Date:
OSTI Identifier:
5017940
Patent Number(s):
5306403 A
Application Number:
PPN: US 7-933376
Assignee:
Martin Marietta Energy Systems, Inc., Oak Ridge, TN (United States)
DOE Contract Number:  
AC05-84OR21400
Resource Type:
Patent
Resource Relation:
Patent File Date: 24 Aug 1992
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; DNA SEQUENCERS; DESIGN; DNA SEQUENCING; RAMAN SPECTROSCOPY; GENETIC MAPPING; EQUIPMENT; LABORATORY EQUIPMENT; LASER SPECTROSCOPY; MAPPING; SPECTROSCOPY; STRUCTURAL CHEMICAL ANALYSIS; 550200* - Biochemistry; 550400 - Genetics

Citation Formats

Vo-Dinh, T. Raman-based system for DNA sequencing-mapping and other separations. United States: N. p., 1994. Web.
Vo-Dinh, T. Raman-based system for DNA sequencing-mapping and other separations. United States.
Vo-Dinh, T. Tue . "Raman-based system for DNA sequencing-mapping and other separations". United States.
@article{osti_5017940,
title = {Raman-based system for DNA sequencing-mapping and other separations},
author = {Vo-Dinh, T},
abstractNote = {DNA sequencing and mapping are performed by using a Raman spectrometer with a surface enhanced Raman scattering (SERS) substrate to enhance the Raman signal. A SERS label is attached to a DNA fragment and then analyzed with the Raman spectrometer to identify the DNA fragment according to characteristics of the Raman spectrum generated. 11 figures.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1994},
month = {4}
}