Electrophoretic detection and separation of mutant DNA using replaceable polymer matrices

Karger, B L; Thilly, W G; Foret, F; Khrapko, K; Koehavong, P; Cohen, A S; Giese, R W

Title: Electrophoretic detection and separation of mutant DNA using replaceable polymer matrices

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Abstract

The disclosure relates to a method for resolving double-stranded DNA species differing by at least one base pair. Each of the species is characterized by an iso-melting domain with a unique melting temperature contiguous with a melting domain of higher thermal stability. 18 figs.

Inventors:: Karger, B L; Thilly, W G; Foret, F; Khrapko, K; Koehavong, P; Cohen, A S; Giese, R W

Issue Date:: 1997-05-27

Sponsoring Org.:: National Inst. of Environmental Health Sciences, Research Triangle Park, NC (United States); USDOE, Washington, DC (United States)

OSTI Identifier:: 489097

Patent Number(s):: 5633129

Application Number:: PAN: 8-190,919

Assignee:: Massachusetts Inst. of Tech., Cambridge, MA (United States); Northeastern Univ., Boston, MA (United States)

Resource Type:: Patent

Resource Relation:: Other Information: PBD: 27 May 1997

Country of Publication:: United States

Language:: English

Subject:: 55 BIOLOGY AND MEDICINE, BASIC STUDIES; DNA; ELECTROPHORESIS; SEPARATION PROCESSES; MOLECULAR STRUCTURE; MOLECULAR BIOLOGY; THERMAL ANALYSIS; GENE MUTATIONS

Citation Formats


                    Karger, B L, Thilly, W G, Foret, F, Khrapko, K, Koehavong, P, Cohen, A S, and Giese, R W. Electrophoretic detection and separation of mutant DNA using replaceable polymer matrices.  United States: N. p., 1997. 
        Web.

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                    Karger, B L, Thilly, W G, Foret, F, Khrapko, K, Koehavong, P, Cohen, A S, & Giese, R W. Electrophoretic detection and separation of mutant DNA using replaceable polymer matrices.  United States.

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                    Karger, B L, Thilly, W G, Foret, F, Khrapko, K, Koehavong, P, Cohen, A S, and Giese, R W. Tue .  
        "Electrophoretic detection and separation of mutant DNA using replaceable polymer matrices".  United States.

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@article{osti_489097,

  title        = {Electrophoretic detection and separation of mutant DNA using replaceable polymer matrices},

  author       = {Karger, B L and Thilly, W G and Foret, F and Khrapko, K and Koehavong, P and Cohen, A S and Giese, R W},

  abstractNote = {The disclosure relates to a method for resolving double-stranded DNA species differing by at least one base pair. Each of the species is characterized by an iso-melting domain with a unique melting temperature contiguous with a melting domain of higher thermal stability. 18 figs.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {1997},

  month        = {5}

}

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