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Title: Electrophoretic detection and separation of mutant DNA using replaceable polymer matrices

Abstract

The disclosure relates to a method for resolving double-stranded DNA species differing by at least one base pair. Each of the species is characterized by an iso-melting domain with a unique melting temperature contiguous with a melting domain of higher thermal stability. 18 figs.

Inventors:
; ; ; ; ; ;
Issue Date:
Sponsoring Org.:
National Inst. of Environmental Health Sciences, Research Triangle Park, NC (United States); USDOE, Washington, DC (United States)
OSTI Identifier:
489097
Patent Number(s):
5,633,129
Application Number:
PAN: 8-190,919
Assignee:
Massachusetts Inst. of Tech., Cambridge, MA (United States); Northeastern Univ., Boston, MA (United States)
Resource Type:
Patent
Resource Relation:
Other Information: PBD: 27 May 1997
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; DNA; ELECTROPHORESIS; SEPARATION PROCESSES; MOLECULAR STRUCTURE; MOLECULAR BIOLOGY; THERMAL ANALYSIS; GENE MUTATIONS

Citation Formats

Karger, B L, Thilly, W G, Foret, F, Khrapko, K, Koehavong, P, Cohen, A S, and Giese, R W. Electrophoretic detection and separation of mutant DNA using replaceable polymer matrices. United States: N. p., 1997. Web.
Karger, B L, Thilly, W G, Foret, F, Khrapko, K, Koehavong, P, Cohen, A S, & Giese, R W. Electrophoretic detection and separation of mutant DNA using replaceable polymer matrices. United States.
Karger, B L, Thilly, W G, Foret, F, Khrapko, K, Koehavong, P, Cohen, A S, and Giese, R W. Tue . "Electrophoretic detection and separation of mutant DNA using replaceable polymer matrices". United States.
@article{osti_489097,
title = {Electrophoretic detection and separation of mutant DNA using replaceable polymer matrices},
author = {Karger, B L and Thilly, W G and Foret, F and Khrapko, K and Koehavong, P and Cohen, A S and Giese, R W},
abstractNote = {The disclosure relates to a method for resolving double-stranded DNA species differing by at least one base pair. Each of the species is characterized by an iso-melting domain with a unique melting temperature contiguous with a melting domain of higher thermal stability. 18 figs.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1997},
month = {5}
}