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Title: Electrophoretic detection and separation of mutant DNA using replaceable polymer matrices

Abstract

The disclosure relates to a method for resolving double-stranded DNA species differing by at least one base pair. Each of the species is characterized by an iso-melting domain with a unique melting temperature contiguous with a melting domain of higher thermal stability. 18 figs.

Inventors:
; ; ; ; ; ;
Issue Date:
Sponsoring Org.:
National Inst. of Environmental Health Sciences, Research Triangle Park, NC (United States); USDOE, Washington, DC (United States)
OSTI Identifier:
489097
Patent Number(s):
5,633,129
Application Number:
PAN: 8-190,919
Assignee:
Massachusetts Inst. of Tech., Cambridge, MA (United States); Northeastern Univ., Boston, MA (United States) PTO; SCA: 550200; PA: EDB-97:087609; SN: 97001799046
Resource Type:
Patent
Resource Relation:
Other Information: PBD: 27 May 1997
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; DNA; ELECTROPHORESIS; SEPARATION PROCESSES; MOLECULAR STRUCTURE; MOLECULAR BIOLOGY; THERMAL ANALYSIS; GENE MUTATIONS

Citation Formats

Karger, B.L., Thilly, W.G., Foret, F., Khrapko, K., Koehavong, P., Cohen, A.S., and Giese, R.W. Electrophoretic detection and separation of mutant DNA using replaceable polymer matrices. United States: N. p., 1997. Web.
Karger, B.L., Thilly, W.G., Foret, F., Khrapko, K., Koehavong, P., Cohen, A.S., & Giese, R.W. Electrophoretic detection and separation of mutant DNA using replaceable polymer matrices. United States.
Karger, B.L., Thilly, W.G., Foret, F., Khrapko, K., Koehavong, P., Cohen, A.S., and Giese, R.W. Tue . "Electrophoretic detection and separation of mutant DNA using replaceable polymer matrices". United States.
@article{osti_489097,
title = {Electrophoretic detection and separation of mutant DNA using replaceable polymer matrices},
author = {Karger, B.L. and Thilly, W.G. and Foret, F. and Khrapko, K. and Koehavong, P. and Cohen, A.S. and Giese, R.W.},
abstractNote = {The disclosure relates to a method for resolving double-stranded DNA species differing by at least one base pair. Each of the species is characterized by an iso-melting domain with a unique melting temperature contiguous with a melting domain of higher thermal stability. 18 figs.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1997},
month = {5}
}