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Title: Method for identifying biochemical and chemical reactions and micromechanical processes using nanomechanical and electronic signal identification

A scanning probe microscope, such as an atomic force microscope (AFM) or a scanning tunneling microscope (STM), is operated in a stationary mode on a site where an activity of interest occurs to measure and identify characteristic time-varying micromotions caused by biological, chemical, mechanical, electrical, optical, or physical processes. The tip and cantilever assembly of an AFM is used as a micromechanical detector of characteristic micromotions transmitted either directly by a site of interest or indirectly through the surrounding medium. Alternatively, the exponential dependence of the tunneling current on the size of the gap in the STM is used to detect micromechanical movement. The stationary mode of operation can be used to observe dynamic biological processes in real time and in a natural environment, such as polymerase processing of DNA for determining the sequence of a DNA molecule. 6 figs.
Inventors:
;
Issue Date:
OSTI Identifier:
462853
Assignee:
Univ. Of California, Oakland, CA (United States) PTO; SCA: 550200; 540220; PA: EDB-97:063153; SN: 97001767249
Patent Number(s):
US 5,620,854/A/
Application Number:
PAN: 8-402,800
Contract Number:
W-7405-ENG-48
Resource Relation:
Other Information: PBD: 15 Apr 1997
Research Org:
University of California
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; 54 ENVIRONMENTAL SCIENCES; DNA SEQUENCING; POLYMERASE CHAIN REACTION; MICROSCOPES; BIOTECHNOLOGY; PROTEIN ENGINEERING; DESIGN; BIODEGRADATION; REMEDIAL ACTION