DNA polymerase having modified nucleotide binding site for DNA sequencing
Abstract
A modified gene encoding a modified DNA polymerase is disclosed. The modified polymerase incorporates dideoxynucleotides at least 20-fold better compared to the corresponding deoxynucleotides as compared with the corresponding naturally-occurring DNA polymerase. 6 figs.
- Inventors:
- Issue Date:
- Research Org.:
- Harvard University
- OSTI Identifier:
- 458581
- Patent Number(s):
- 5614365
- Application Number:
- PAN: 8-337,615
- Assignee:
- Harvard Coll., Cambridge, MA (United States)
- DOE Contract Number:
- FG02-88ER60688
- Resource Type:
- Patent
- Resource Relation:
- Other Information: PBD: 25 Mar 1997
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 55 BIOLOGY AND MEDICINE, BASIC STUDIES; DNA POLYMERASES; GENES; DNA SEQUENCING; RECEPTORS; NUCLEOTIDES; POLYMERASE CHAIN REACTION; BIOTECHNOLOGY
Citation Formats
Tabor, S, and Richardson, C. DNA polymerase having modified nucleotide binding site for DNA sequencing. United States: N. p., 1997.
Web.
Tabor, S, & Richardson, C. DNA polymerase having modified nucleotide binding site for DNA sequencing. United States.
Tabor, S, and Richardson, C. Tue .
"DNA polymerase having modified nucleotide binding site for DNA sequencing". United States.
@article{osti_458581,
title = {DNA polymerase having modified nucleotide binding site for DNA sequencing},
author = {Tabor, S and Richardson, C},
abstractNote = {A modified gene encoding a modified DNA polymerase is disclosed. The modified polymerase incorporates dideoxynucleotides at least 20-fold better compared to the corresponding deoxynucleotides as compared with the corresponding naturally-occurring DNA polymerase. 6 figs.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Mar 25 00:00:00 EST 1997},
month = {Tue Mar 25 00:00:00 EST 1997}
}
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