DNA polymerase having modified nucleotide binding site for DNA sequencing
Abstract
A modified gene encoding a modified DNA polymerase is disclosed. The modified polymerase incorporates dideoxynucleotides at least 20-fold better compared to the corresponding deoxynucleotides as compared with the corresponding naturally-occurring DNA polymerase. 6 figs.
- Inventors:
- Issue Date:
- Research Org.:
- Harvard University
- OSTI Identifier:
- 458581
- Patent Number(s):
- 5614365
- Application Number:
- PAN: 8-337,615
- Assignee:
- Harvard Coll., Cambridge, MA (United States)
- DOE Contract Number:
- FG02-88ER60688
- Resource Type:
- Patent
- Resource Relation:
- Other Information: PBD: 25 Mar 1997
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 55 BIOLOGY AND MEDICINE, BASIC STUDIES; DNA POLYMERASES; GENES; DNA SEQUENCING; RECEPTORS; NUCLEOTIDES; POLYMERASE CHAIN REACTION; BIOTECHNOLOGY
Citation Formats
Tabor, S, and Richardson, C. DNA polymerase having modified nucleotide binding site for DNA sequencing. United States: N. p., 1997.
Web.
Tabor, S, & Richardson, C. DNA polymerase having modified nucleotide binding site for DNA sequencing. United States.
Tabor, S, and Richardson, C. Tue .
"DNA polymerase having modified nucleotide binding site for DNA sequencing". United States.
@article{osti_458581,
title = {DNA polymerase having modified nucleotide binding site for DNA sequencing},
author = {Tabor, S and Richardson, C},
abstractNote = {A modified gene encoding a modified DNA polymerase is disclosed. The modified polymerase incorporates dideoxynucleotides at least 20-fold better compared to the corresponding deoxynucleotides as compared with the corresponding naturally-occurring DNA polymerase. 6 figs.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1997},
month = {3}
}
Search for the full text at the U.S. Patent and Trademark Office
Note: You will be redirected to the USPTO site, which may require a pop-up blocker to be deactivated to view the patent. If so, you will need to manually turn off your browser's pop-up blocker, typically found within the browser settings. (See DOE Patents FAQs for more information.)
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.