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Title: DNA polymerase having modified nucleotide binding site for DNA sequencing

Abstract

A modified gene encoding a modified DNA polymerase is disclosed. The modified polymerase incorporates dideoxynucleotides at least 20-fold better compared to the corresponding deoxynucleotides as compared with the corresponding naturally-occurring DNA polymerase. 6 figs.

Inventors:
;
Issue Date:
Research Org.:
Harvard University
OSTI Identifier:
458581
Patent Number(s):
5,614,365
Application Number:
PAN: 8-337,615
Assignee:
Harvard Coll., Cambridge, MA (United States)
DOE Contract Number:  
FG02-88ER60688
Resource Type:
Patent
Resource Relation:
Other Information: PBD: 25 Mar 1997
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; DNA POLYMERASES; GENES; DNA SEQUENCING; RECEPTORS; NUCLEOTIDES; POLYMERASE CHAIN REACTION; BIOTECHNOLOGY

Citation Formats

Tabor, S, and Richardson, C. DNA polymerase having modified nucleotide binding site for DNA sequencing. United States: N. p., 1997. Web.
Tabor, S, & Richardson, C. DNA polymerase having modified nucleotide binding site for DNA sequencing. United States.
Tabor, S, and Richardson, C. Tue . "DNA polymerase having modified nucleotide binding site for DNA sequencing". United States.
@article{osti_458581,
title = {DNA polymerase having modified nucleotide binding site for DNA sequencing},
author = {Tabor, S and Richardson, C},
abstractNote = {A modified gene encoding a modified DNA polymerase is disclosed. The modified polymerase incorporates dideoxynucleotides at least 20-fold better compared to the corresponding deoxynucleotides as compared with the corresponding naturally-occurring DNA polymerase. 6 figs.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1997},
month = {3}
}