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Title: DNA polymerase having modified nucleotide binding site for DNA sequencing

A modified gene encoding a modified DNA polymerase is disclosed. The modified polymerase incorporates dideoxynucleotides at least 20-fold better compared to the corresponding deoxynucleotides as compared with the corresponding naturally-occurring DNA polymerase. 6 figs.
Inventors:
;
Issue Date:
OSTI Identifier:
458581
Assignee:
Harvard Coll., Cambridge, MA (United States) PTO; SCA: 550200; PA: EDB-97:057520; SN: 97001758981
Patent Number(s):
US 5,614,365/A/
Application Number:
PAN: 8-337,615
Contract Number:
FG02-88ER60688
Resource Relation:
Other Information: PBD: 25 Mar 1997
Research Org:
Harvard University
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; DNA POLYMERASES; GENES; DNA SEQUENCING; RECEPTORS; NUCLEOTIDES; POLYMERASE CHAIN REACTION; BIOTECHNOLOGY