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Title: Oncoprotein protein kinase

An isolated polypeptide (JNK) characterized by having a molecular weight of 46 kD as determined by reducing SDS-PAGE is disclosed. The polypeptide has serine and threonine kinase activity, phosphorylating the c-Jun N-terminal activation domain and polynucleotide sequences. The method of detection of JNK is also provided. JNK phosphorylates c-Jun N-terminal activation domain which affects gene expression from AP-1 sites. 44 figs.
Inventors:
; ;
Issue Date:
OSTI Identifier:
441865
Assignee:
Univ. of California, Oakland, CA (United States) PTO; SCA: 550200; PA: EDB-97:044155; SN: 97001739245
Patent Number(s):
US 5,605,808/A/
Application Number:
PAN: 8-444,393; CNN: Grant CA-50528;Grant CA-58396
Contract Number:
FG03-86ER60429
Resource Relation:
Other Information: PBD: 25 Feb 1997
Research Org:
University of California
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; POLYPEPTIDES; PHOSPHOTRANSFERASES; ENZYME ACTIVITY; AMINO ACID SEQUENCE; PHOSPHORYLATION; GENE REGULATION; CHEMICAL COMPOSITION