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Title: Laser-induced differential normalized fluorescence method for cancer diagnosis

Abstract

An apparatus and method for cancer diagnosis are disclosed. The diagnostic method includes the steps of irradiating a tissue sample with monochromatic excitation light, producing a laser-induced fluorescence spectrum from emission radiation generated by interaction of the excitation light with the tissue sample, and dividing the intensity at each wavelength of the laser-induced fluorescence spectrum by the integrated area under the laser-induced fluorescence spectrum to produce a normalized spectrum. A mathematical difference between the normalized spectrum and an average value of a reference set of normalized spectra which correspond to normal tissues is calculated, which provides for amplifying small changes in weak signals from malignant tissues for improved analysis. The calculated differential normalized spectrum is correlated to a specific condition of a tissue sample. 5 figs.

Inventors:
; ;
Issue Date:
Research Org.:
Lockheed Martin Energy Syst Inc
OSTI Identifier:
415747
Patent Number(s):
5,579,773
Application Number:
PAN: 8-316,132
Assignee:
Martin Marietta Energy Systems, Inc., Oak Ridge, TN (United States)
DOE Contract Number:  
AC05-84OR21400
Resource Type:
Patent
Resource Relation:
Other Information: PBD: 3 Dec 1996
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; LASER RADIATION; DIAGNOSTIC USES; NEOPLASMS; DIAGNOSIS; FLUORESCENCE SPECTROSCOPY

Citation Formats

Vo-Dinh, T, Panjehpour, M, and Overholt, B F. Laser-induced differential normalized fluorescence method for cancer diagnosis. United States: N. p., 1996. Web.
Vo-Dinh, T, Panjehpour, M, & Overholt, B F. Laser-induced differential normalized fluorescence method for cancer diagnosis. United States.
Vo-Dinh, T, Panjehpour, M, and Overholt, B F. Tue . "Laser-induced differential normalized fluorescence method for cancer diagnosis". United States.
@article{osti_415747,
title = {Laser-induced differential normalized fluorescence method for cancer diagnosis},
author = {Vo-Dinh, T and Panjehpour, M and Overholt, B F},
abstractNote = {An apparatus and method for cancer diagnosis are disclosed. The diagnostic method includes the steps of irradiating a tissue sample with monochromatic excitation light, producing a laser-induced fluorescence spectrum from emission radiation generated by interaction of the excitation light with the tissue sample, and dividing the intensity at each wavelength of the laser-induced fluorescence spectrum by the integrated area under the laser-induced fluorescence spectrum to produce a normalized spectrum. A mathematical difference between the normalized spectrum and an average value of a reference set of normalized spectra which correspond to normal tissues is calculated, which provides for amplifying small changes in weak signals from malignant tissues for improved analysis. The calculated differential normalized spectrum is correlated to a specific condition of a tissue sample. 5 figs.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1996},
month = {12}
}