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Title: Multiplexed capillary electrophoresis system

The invention provides a side-entry optical excitation geometry for use in a multiplexed capillary electrophoresis system. A charge-injection device is optically coupled to capillaries in the array such that the interior of a capillary is imaged onto only one pixel. In Sanger-type 4-label DNA sequencing reactions, nucleotide identification (``base calling``) is improved by using two long-pass filters to split fluorescence emission into two emission channels. A binary poly(ethyleneoxide) matrix is used in the electrophoretic separations. 19 figs.
Inventors:
; ; ; ;
Issue Date:
OSTI Identifier:
415746
Assignee:
Iowa State Univ. Research Foundation, Inc., Ames, IA (United States) PTO; SCA: 550200; PA: EDB-97:016816; SN: 97001714619
Patent Number(s):
US 5,582,705/A/
Application Number:
PAN: 8-444,565
Contract Number:
W-7405-ENG-82
Resource Relation:
Other Information: PBD: 10 Dec 1996
Research Org:
Iowa State University
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; EQUIPMENT; DESIGN; NUCLEOTIDES; ELECTROPHORESIS; MOLECULAR BIOLOGY