Human MSH2 protein
Abstract
The human MSH2 gene, responsible for hereditary non-polyposis colorectal cancer, was identified by virtue of its homology to the MutS class of genes, which are involved in DNA mismatch repair. The sequence of cDNA clones of the human gene are provided, and the sequence of the gene can be used to demonstrate the existence of germ line mutations in hereditary non-polyposis colorectal cancer (HNPCC) kindreds, as well as in replication error{sup +} (RER{sup +}) tumor cells. 19 figs.
- Inventors:
- Issue Date:
- Research Org.:
- Eleanor Roosevelt Institute
- OSTI Identifier:
- 415739
- Patent Number(s):
- 5591826
- Application Number:
- PAN: 8-457,176; CNN: Grant CA47527;CA09320;GM26449;CA09243;CA41183;CA42705;CA57435;CA35494
- Assignee:
- Johns Hopkins Univ., Baltimore, MD (United States)
- DOE Contract Number:
- FG02-91ER61139
- Resource Type:
- Patent
- Resource Relation:
- Other Information: PBD: 7 Jan 1997
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 55 BIOLOGY AND MEDICINE, BASIC STUDIES; LARGE INTESTINE; NEOPLASMS; RECTUM; ONCOGENES; DNA SEQUENCING; MAN; DNA-CLONING; HEREDITARY DISEASES; GENE MUTATIONS
Citation Formats
Chapelle, A de la, Vogelstein, B, and Kinzler, K W. Human MSH2 protein. United States: N. p., 1997.
Web.
Chapelle, A de la, Vogelstein, B, & Kinzler, K W. Human MSH2 protein. United States.
Chapelle, A de la, Vogelstein, B, and Kinzler, K W. Tue .
"Human MSH2 protein". United States.
@article{osti_415739,
title = {Human MSH2 protein},
author = {Chapelle, A de la and Vogelstein, B and Kinzler, K W},
abstractNote = {The human MSH2 gene, responsible for hereditary non-polyposis colorectal cancer, was identified by virtue of its homology to the MutS class of genes, which are involved in DNA mismatch repair. The sequence of cDNA clones of the human gene are provided, and the sequence of the gene can be used to demonstrate the existence of germ line mutations in hereditary non-polyposis colorectal cancer (HNPCC) kindreds, as well as in replication error{sup +} (RER{sup +}) tumor cells. 19 figs.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Jan 07 00:00:00 EST 1997},
month = {Tue Jan 07 00:00:00 EST 1997}
}
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