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Title: Human MSH2 protein

The human MSH2 gene, responsible for hereditary non-polyposis colorectal cancer, was identified by virtue of its homology to the MutS class of genes, which are involved in DNA mismatch repair. The sequence of cDNA clones of the human gene are provided, and the sequence of the gene can be used to demonstrate the existence of germ line mutations in hereditary non-polyposis colorectal cancer (HNPCC) kindreds, as well as in replication error{sup +} (RER{sup +}) tumor cells. 19 figs.
Inventors:
; ;
Issue Date:
OSTI Identifier:
415739
Assignee:
Johns Hopkins Univ., Baltimore, MD (United States) PTO; SCA: 550200; 550900; PA: EDB-97:016820; SN: 97001714577
Patent Number(s):
US 5,591,826/A/
Application Number:
PAN: 8-457,176; CNN: Grant CA47527;CA09320;GM26449;CA09243;CA41183;CA42705;CA57435;CA35494
Contract Number:
FG02-91ER61139
Resource Relation:
Other Information: PBD: 7 Jan 1997
Research Org:
Eleanor Roosevelt Institute
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; LARGE INTESTINE; NEOPLASMS; RECTUM; ONCOGENES; DNA SEQUENCING; MAN; DNA-CLONING; HEREDITARY DISEASES; GENE MUTATIONS