Silicon-based sleeve devices for chemical reactions
Abstract
A silicon-based sleeve type chemical reaction chamber is described that combines heaters, such as doped polysilicon for heating, and bulk silicon for convection cooling. The reaction chamber combines a critical ratio of silicon and silicon nitride to the volume of material to be heated (e.g., a liquid) in order to provide uniform heating, yet low power requirements. The reaction chamber will also allow the introduction of a secondary tube (e.g., plastic) into the reaction sleeve that contains the reaction mixture thereby alleviating any potential materials incompatibility issues. The reaction chamber may be utilized in any chemical reaction system for synthesis or processing of organic, inorganic, or biochemical reactions, such as the polymerase chain reaction (PCR) and/or other DNA reactions, such as the ligase chain reaction, which are examples of a synthetic, thermal-cycling-based reaction. The reaction chamber may also be used in synthesis instruments, particularly those for DNA amplification and synthesis. 32 figs.
- Inventors:
- Issue Date:
- Research Org.:
- Univ. of California (United States)
- OSTI Identifier:
- 415720
- Patent Number(s):
- 5589136
- Application Number:
- PAN: 8-492,678
- Assignee:
- Univ. of California, Oakland, CA (United States)
- DOE Contract Number:
- W-7405-ENG-48
- Resource Type:
- Patent
- Resource Relation:
- Other Information: PBD: 31 Dec 1996
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 55 BIOLOGY AND MEDICINE, BASIC STUDIES; BIOREACTORS; DESIGN; POLYMERASE CHAIN REACTION; DNA HYBRIDIZATION; TEMPERATURE CONTROL; THERMAL CYCLING
Citation Formats
Northrup, M A, Mariella, Jr, R P, Carrano, A V, and Balch, J W. Silicon-based sleeve devices for chemical reactions. United States: N. p., 1996.
Web.
Northrup, M A, Mariella, Jr, R P, Carrano, A V, & Balch, J W. Silicon-based sleeve devices for chemical reactions. United States.
Northrup, M A, Mariella, Jr, R P, Carrano, A V, and Balch, J W. Tue .
"Silicon-based sleeve devices for chemical reactions". United States.
@article{osti_415720,
title = {Silicon-based sleeve devices for chemical reactions},
author = {Northrup, M A and Mariella, Jr, R P and Carrano, A V and Balch, J W},
abstractNote = {A silicon-based sleeve type chemical reaction chamber is described that combines heaters, such as doped polysilicon for heating, and bulk silicon for convection cooling. The reaction chamber combines a critical ratio of silicon and silicon nitride to the volume of material to be heated (e.g., a liquid) in order to provide uniform heating, yet low power requirements. The reaction chamber will also allow the introduction of a secondary tube (e.g., plastic) into the reaction sleeve that contains the reaction mixture thereby alleviating any potential materials incompatibility issues. The reaction chamber may be utilized in any chemical reaction system for synthesis or processing of organic, inorganic, or biochemical reactions, such as the polymerase chain reaction (PCR) and/or other DNA reactions, such as the ligase chain reaction, which are examples of a synthetic, thermal-cycling-based reaction. The reaction chamber may also be used in synthesis instruments, particularly those for DNA amplification and synthesis. 32 figs.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1996},
month = {12}
}