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Title: Silicon-based sleeve devices for chemical reactions

A silicon-based sleeve type chemical reaction chamber is described that combines heaters, such as doped polysilicon for heating, and bulk silicon for convection cooling. The reaction chamber combines a critical ratio of silicon and silicon nitride to the volume of material to be heated (e.g., a liquid) in order to provide uniform heating, yet low power requirements. The reaction chamber will also allow the introduction of a secondary tube (e.g., plastic) into the reaction sleeve that contains the reaction mixture thereby alleviating any potential materials incompatibility issues. The reaction chamber may be utilized in any chemical reaction system for synthesis or processing of organic, inorganic, or biochemical reactions, such as the polymerase chain reaction (PCR) and/or other DNA reactions, such as the ligase chain reaction, which are examples of a synthetic, thermal-cycling-based reaction. The reaction chamber may also be used in synthesis instruments, particularly those for DNA amplification and synthesis. 32 figs.
Inventors:
; ; ;
Issue Date:
OSTI Identifier:
415720
Assignee:
Univ. of California, Oakland, CA (United States) PTO; SCA: 550200; PA: EDB-97:016810; SN: 97001714590
Patent Number(s):
US 5,589,136/A/
Application Number:
PAN: 8-492,678
Contract Number:
W-7405-ENG-48
Resource Relation:
Other Information: PBD: 31 Dec 1996
Research Org:
University of California
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; BIOREACTORS; DESIGN; POLYMERASE CHAIN REACTION; DNA HYBRIDIZATION; TEMPERATURE CONTROL; THERMAL CYCLING

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