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Title: Method for quantifying optical properties of the human lens

Abstract

A method is disclosed for quantifying optical properties of the human lens. The present invention includes the application of fiberoptic, OMA-based instrumentation as an in vivo diagnostic tool for the human ocular lens. Rapid, noninvasive and comprehensive assessment of the optical characteristics of a lens using very modest levels of exciting light are described. Typically, the backscatter and fluorescence spectra (from about 300- to 900-nm) elicited by each of several exciting wavelengths (from about 300- to 600-nm) are collected within a few seconds. The resulting optical signature of individual lenses is then used to assess the overall optical quality of the lens by comparing the results with a database of similar measurements obtained from a reference set of normal human lenses having various ages. Several metrics have been identified which gauge the optical quality of a given lens relative to the norm for the subject`s chronological age. These metrics may also serve to document accelerated optical aging and/or as early indicators of cataract or other disease processes. 8 figs.

Inventors:
; ; ; ;
Issue Date:
Research Org.:
Univ. of California (United States)
Sponsoring Org.:
USDOE, Washington, DC (United States)
OSTI Identifier:
350324
Patent Number(s):
5894340
Application Number:
PAN: 8-744,678
Assignee:
Univ. of California, Los Alamos, NM (United States)
DOE Contract Number:  
W-7405-ENG-36
Resource Type:
Patent
Resource Relation:
Other Information: PBD: 13 Apr 1999
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; MAN; CRYSTALLINE LENS; OPTICAL PROPERTIES; FIBER OPTICS; MEASURING INSTRUMENTS; MEDICINE; CATARACTS; DIAGNOSIS

Citation Formats

Loree, T R, Bigio, I J, Zuclich, J A, Shimada, Tsutomu, and Strobl, K. Method for quantifying optical properties of the human lens. United States: N. p., 1999. Web.
Loree, T R, Bigio, I J, Zuclich, J A, Shimada, Tsutomu, & Strobl, K. Method for quantifying optical properties of the human lens. United States.
Loree, T R, Bigio, I J, Zuclich, J A, Shimada, Tsutomu, and Strobl, K. Tue . "Method for quantifying optical properties of the human lens". United States.
@article{osti_350324,
title = {Method for quantifying optical properties of the human lens},
author = {Loree, T R and Bigio, I J and Zuclich, J A and Shimada, Tsutomu and Strobl, K},
abstractNote = {A method is disclosed for quantifying optical properties of the human lens. The present invention includes the application of fiberoptic, OMA-based instrumentation as an in vivo diagnostic tool for the human ocular lens. Rapid, noninvasive and comprehensive assessment of the optical characteristics of a lens using very modest levels of exciting light are described. Typically, the backscatter and fluorescence spectra (from about 300- to 900-nm) elicited by each of several exciting wavelengths (from about 300- to 600-nm) are collected within a few seconds. The resulting optical signature of individual lenses is then used to assess the overall optical quality of the lens by comparing the results with a database of similar measurements obtained from a reference set of normal human lenses having various ages. Several metrics have been identified which gauge the optical quality of a given lens relative to the norm for the subject`s chronological age. These metrics may also serve to document accelerated optical aging and/or as early indicators of cataract or other disease processes. 8 figs.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1999},
month = {4}
}