Microinjector for blasocysts
Abstract
An electromechanical device is disclosed for driving the tip of a microinjection cannula, or needle, through the outer barrier of a blastocyst, cell, or cell nucleus for the injection of cells or other bioactive materials. Either a flexible frame or a ram moving within a base member is employed. Cannula motion is achieved by means of a piezoelectric stack and spring return system. The thrust motion over a predetermined microscopic distance is achieved without cannula setback prior to the thrust movement. Instead of specially prepared beveled and tipped needles, standard unimproved cannulas or needles can be used. 6 figs.
- Inventors:
- Issue Date:
- Research Org.:
- Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
- Sponsoring Org.:
- USDOE, Washington, DC (United States)
- OSTI Identifier:
- 335469
- Patent Number(s):
- 5877008
- Application Number:
- PAN: 8-898,232
- Assignee:
- Lockheed Martin Energy Research Corp., Oak Ridge, TN (United States)
- DOE Contract Number:
- AC05-96OR22464
- Resource Type:
- Patent
- Resource Relation:
- Other Information: PBD: 2 Mar 1999
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 55 BIOLOGY AND MEDICINE, BASIC STUDIES; DESIGN; LABORATORY EQUIPMENT; SUBCELLULAR DISTRIBUTION; CELL CONSTITUENTS; INJECTION; CELL MEMBRANES
Citation Formats
Remenyik, C J, Woychik, R P, Patek, D R, Hawk, J A, and Turner, J C. Microinjector for blasocysts. United States: N. p., 1999.
Web.
Remenyik, C J, Woychik, R P, Patek, D R, Hawk, J A, & Turner, J C. Microinjector for blasocysts. United States.
Remenyik, C J, Woychik, R P, Patek, D R, Hawk, J A, and Turner, J C. Tue .
"Microinjector for blasocysts". United States.
@article{osti_335469,
title = {Microinjector for blasocysts},
author = {Remenyik, C J and Woychik, R P and Patek, D R and Hawk, J A and Turner, J C},
abstractNote = {An electromechanical device is disclosed for driving the tip of a microinjection cannula, or needle, through the outer barrier of a blastocyst, cell, or cell nucleus for the injection of cells or other bioactive materials. Either a flexible frame or a ram moving within a base member is employed. Cannula motion is achieved by means of a piezoelectric stack and spring return system. The thrust motion over a predetermined microscopic distance is achieved without cannula setback prior to the thrust movement. Instead of specially prepared beveled and tipped needles, standard unimproved cannulas or needles can be used. 6 figs.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1999},
month = {3}
}
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Works referenced in this record:
[50] Production of chimeras between embryonic stem cells and embryos
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- Methods in Enzymology