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Title: Modified Acyl-ACP desaturase

Abstract

Disclosed is a method for modifying the chain length and double bond positional specificities of a soluble plant fatty acid desaturase. More specifically, the method involves modifying amino acid contact residues in the substrate binding channel of the soluble fatty acid desaturase which contact the fatty acid. Specifically disclosed is the modification of an acyl-ACP desaturase. Amino acid contact residues which lie within the substrate binding channel are identified, and subsequently replaced with different residues to effect the modification of activity. 2 figs.

Inventors:
; ; ;
Issue Date:
Research Org.:
Associated Universities Inc
Sponsoring Org.:
USDOE, Washington, DC (United States)
OSTI Identifier:
335463
Patent Number(s):
5888790
Application Number:
PAN: 8-853,979
Assignee:
Brookhaven Science Associates LLC, Upton, NY (United States)
DOE Contract Number:  
AC02-76CH00016
Resource Type:
Patent
Resource Relation:
Other Information: PBD: 30 Mar 1999
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; CARBOXYLIC ACIDS; OXYGENASES; ENZYME ACTIVITY; AMINO ACIDS; MOLECULAR STRUCTURE

Citation Formats

Cahoon, E B, Shanklin, J, Lindqvist, Y, and Schneider, G. Modified Acyl-ACP desaturase. United States: N. p., 1999. Web.
Cahoon, E B, Shanklin, J, Lindqvist, Y, & Schneider, G. Modified Acyl-ACP desaturase. United States.
Cahoon, E B, Shanklin, J, Lindqvist, Y, and Schneider, G. Tue . "Modified Acyl-ACP desaturase". United States.
@article{osti_335463,
title = {Modified Acyl-ACP desaturase},
author = {Cahoon, E B and Shanklin, J and Lindqvist, Y and Schneider, G},
abstractNote = {Disclosed is a method for modifying the chain length and double bond positional specificities of a soluble plant fatty acid desaturase. More specifically, the method involves modifying amino acid contact residues in the substrate binding channel of the soluble fatty acid desaturase which contact the fatty acid. Specifically disclosed is the modification of an acyl-ACP desaturase. Amino acid contact residues which lie within the substrate binding channel are identified, and subsequently replaced with different residues to effect the modification of activity. 2 figs.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1999},
month = {3}
}