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Title: Apparatus and method for performing microfluidic manipulations for chemical analysis and synthesis

Abstract

A microchip laboratory system and method provide fluid manipulations for a variety of applications, including sample injection for microchip chemical separations. The microchip is fabricated using standard photolithographic procedures and chemical wet etching, with the substrate and cover plate joined using direct bonding. Capillary electrophoresis and electrochromatography are performed in channels formed in the substrate. Analytes are loaded into a four-way intersection of channels by electrokinetically pumping the analyte through the intersection, followed by switching of the potentials to force an analyte plug into the separation channel. 46 figs.

Inventors:
Issue Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE, Washington, DC (United States)
OSTI Identifier:
321255
Patent Number(s):
5858195
Application Number:
PAN: 8-776,645
Assignee:
Lockheed Martin Energy Research Corp., Oak Ridge, TN (United States)
DOE Contract Number:  
AC05-84OR21400
Resource Type:
Patent
Resource Relation:
Other Information: PBD: 12 Jan 1999
Country of Publication:
United States
Language:
English
Subject:
40 CHEMISTRY; 42 ENGINEERING NOT INCLUDED IN OTHER CATEGORIES; SAMPLE HOLDERS; MINIATURIZATION; MICROELECTRONICS; ELECTROPHORESIS; CHROMATOGRAPHY; DESIGN; MATERIALS HANDLING

Citation Formats

Ramsey, J M. Apparatus and method for performing microfluidic manipulations for chemical analysis and synthesis. United States: N. p., 1999. Web.
Ramsey, J M. Apparatus and method for performing microfluidic manipulations for chemical analysis and synthesis. United States.
Ramsey, J M. Tue . "Apparatus and method for performing microfluidic manipulations for chemical analysis and synthesis". United States.
@article{osti_321255,
title = {Apparatus and method for performing microfluidic manipulations for chemical analysis and synthesis},
author = {Ramsey, J M},
abstractNote = {A microchip laboratory system and method provide fluid manipulations for a variety of applications, including sample injection for microchip chemical separations. The microchip is fabricated using standard photolithographic procedures and chemical wet etching, with the substrate and cover plate joined using direct bonding. Capillary electrophoresis and electrochromatography are performed in channels formed in the substrate. Analytes are loaded into a four-way intersection of channels by electrokinetically pumping the analyte through the intersection, followed by switching of the potentials to force an analyte plug into the separation channel. 46 figs.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1999},
month = {1}
}