Process for producing 8-fluoropurines
Abstract
An efficient, regio-controlled approach to the synthesis of 8-fluoropurines by direct fluorination of purines with dilute elemental fluorine, or acetyl hypofluorite, is provided. In a preferred embodiment, a purine compound is dissolved in a polar solvent and reacted with a dilute mixture of F{sub 2} in He or other inert gas.
- Inventors:
- Issue Date:
- Research Org.:
- Univ. of California (United States)
- Sponsoring Org.:
- USDOE, Washington, DC (United States)
- OSTI Identifier:
- 321251
- Patent Number(s):
- 5861503
- Application Number:
- PAN: 8-846,424
- Assignee:
- Univ. of California, Oakland, CA (United States)
- DOE Contract Number:
- FC03-87ER60615
- Resource Type:
- Patent
- Resource Relation:
- Other Information: PBD: 19 Jan 1999
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 40 CHEMISTRY; PURINES; FLUORINATION; FLUORINATED AROMATIC HYDROCARBONS; SYNTHESIS
Citation Formats
Barrio, J R, Satyamurthy, N, Namavari, M, and Phelps, M E. Process for producing 8-fluoropurines. United States: N. p., 1999.
Web.
Barrio, J R, Satyamurthy, N, Namavari, M, & Phelps, M E. Process for producing 8-fluoropurines. United States.
Barrio, J R, Satyamurthy, N, Namavari, M, and Phelps, M E. Tue .
"Process for producing 8-fluoropurines". United States.
@article{osti_321251,
title = {Process for producing 8-fluoropurines},
author = {Barrio, J R and Satyamurthy, N and Namavari, M and Phelps, M E},
abstractNote = {An efficient, regio-controlled approach to the synthesis of 8-fluoropurines by direct fluorination of purines with dilute elemental fluorine, or acetyl hypofluorite, is provided. In a preferred embodiment, a purine compound is dissolved in a polar solvent and reacted with a dilute mixture of F{sub 2} in He or other inert gas.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1999},
month = {1}
}
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