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Title: Restoration of normal phenotype in cancer cells

Abstract

A method for reversing expression of malignant phenotype in cancer cells is described. The method comprises applying {beta}{sub 1} integrin function-blocking antibody to the cells. The method can be used to assess the progress of cancer therapy. Human breast epithelial cells were shown to be particularly responsive. 14 figs.

Inventors:
;
Issue Date:
Research Org.:
University of California
Sponsoring Org.:
USDOE, Washington, DC (United States)
OSTI Identifier:
321195
Patent Number(s):
5,846,536
Application Number:
PAN: 8-726,230
Assignee:
Univ. of California, Oakland, CA (United States) PTO; SCA: 550600; PA: EDB-99:031771; SN: 99002058505
DOE Contract Number:  
AC03-76SF00098
Resource Type:
Patent
Resource Relation:
Other Information: PBD: 8 Dec 1998
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; NEOPLASMS; PHENOTYPE; ANTIBODIES; MAMMARY GLANDS; TUMOR CELLS; EPITHELIUM; WOMEN

Citation Formats

Bissell, M.J., and Weaver, V.M. Restoration of normal phenotype in cancer cells. United States: N. p., 1998. Web.
Bissell, M.J., & Weaver, V.M. Restoration of normal phenotype in cancer cells. United States.
Bissell, M.J., and Weaver, V.M. Tue . "Restoration of normal phenotype in cancer cells". United States.
@article{osti_321195,
title = {Restoration of normal phenotype in cancer cells},
author = {Bissell, M.J. and Weaver, V.M.},
abstractNote = {A method for reversing expression of malignant phenotype in cancer cells is described. The method comprises applying {beta}{sub 1} integrin function-blocking antibody to the cells. The method can be used to assess the progress of cancer therapy. Human breast epithelial cells were shown to be particularly responsive. 14 figs.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1998},
month = {12}
}