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Title: Combined electrophoresis-electrospray interface and method

A system and method for analyzing molecular constituents of a composition sample include: forming a solution of the sample, separating the solution by capillary electrophoresis into an eluent of constituents longitudinally separated according to their relative electrophoretic mobilities, electrospraying the eluent to form a charged spray in which the molecular constituents have a temporal distribution; and detecting or collecting the separated constituents in accordance with the temporal distribution in the spray. A first high-voltage (e.g., 5--100 kVDC) is applied to the solution. The spray is charged by applying a second high voltage (e.g.,{+-}2--8 kVDC) between the eluent at the capillary exit and a cathode spaced in front of the exit. A complete electrical circuit is formed by a conductor which directly contacts the eluent at the capillary exit, or by conduction through a sheath electrode discharged in an annular sheath flow about the capillary exit. 21 figs.
Inventors:
; ;
Issue Date:
OSTI Identifier:
27740
Assignee:
Battelle Memorial Inst., Richland, WA (United States) PTO; SCA: 400105; PA: EDB-95:058345; SN: 94001276565
Patent Number(s):
US RE 34,757/E/
Application Number:
PAN: 7-803,145
Contract Number:
AC06-76RL01830
Resource Relation:
Other Information: DN: Reissue of US Pat. No. 4,885,076, which was issued Dec. 5, 1989; PBD: 18 Oct 1994
Research Org:
Battelle Memorial Institute
Country of Publication:
United States
Language:
English
Subject:
40 CHEMISTRY; MIXTURES; ELECTROPHORESIS; ATOMIZATION; SAMPLE PREPARATION; ELECTRIC FIELDS; ELECTROLYTIC CELLS; ELECTRODES