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Title: Triamine chelants, their derivatives, complexes and conjugates

A group of functionalized triamine chelants and their derivatives that form complexes with radioactive metal ions are disclosed. The complexes can be covalently attached to a protein or an antibody or antibody fragment and used for therapeutic and/or diagnostic purposes. The chelants are of the formula, as shown in the accompanying diagrams, wherein n, m, R, R{sup 1}, R{sup 2} and L are defined in the specification.
Inventors:
; ;
Issue Date:
OSTI Identifier:
27713
Assignee:
Univ. of Missouri, Columbia, MO (United States) PTO; SCA: 550601; PA: EDB-95:059846; SN: 95001354437
Patent Number(s):
US 5,395,608/A/
Application Number:
PAN: 7-697,861
Contract Number:
FG02-86ER60400
Resource Relation:
Other Information: PBD: 7 Mar 1995
Research Org:
University of Missouri
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; RADIOPHARMACEUTICALS; CHEMICAL PREPARATION; CHELATING AGENTS; THERAPEUTIC USES; DIAGNOSTIC USES; NUCLEAR MEDICINE