Gene for ataxia-telangiectasia complementation group D (ATDC)

Title: Gene for ataxia-telangiectasia complementation group D (ATDC)

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Disclosed herein is a new gene, an AT gene for complementation group D, the ATDC gene and fragments thereof. Nucleic acid probes for the gene are provided as well as proteins encoded by the gene, cDNA therefrom, preferably a 3 kilobase (kb) cDNA, and recombinant nucleic acid molecules for expression of the proteins. Further disclosed are methods to detect mutations in the gene, preferably methods employing the polymerase chain reaction (PCR). Also disclosed are methods to detect AT genes from other AT complementation groups. 30 figs.

Inventors:: Murnane, J.P.; Painter, R.B.; Kapp, L.N.; Yu, L.C.

Issue Date:: 1995-03-07

OSTI Identifier:: 27712

Assignee:: Univ. of California, Oakland, CA (United States) PTO; SCA: 550900; PA: EDB-95:060019; SN: 95001354433

Patent Number(s):: US 5,395,767/A/

Application Number:: PAN: 7-903,466

Contract Number:: W-7405-ENG-48; AC03-76SF01012

Resource Relation:: Other Information: PBD: 7 Mar 1995

Research Org:: University of California

Sponsoring Org:: USDOE

Country of Publication:: United States

Language:: English

Subject:: 55 BIOLOGY AND MEDICINE, BASIC STUDIES; NERVOUS SYSTEM DISEASES; GENES; VASCULAR DISEASES; GENE MUTATIONS; MEASURING METHODS; GENE REGULATION; DNA-CLONING

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Gene for ataxia-telangiectasia complementation group D (ATDC)

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