In situ mechanical characterization of a single cell-cell adhesion interface under large strain

Yang, Ruiguo; Lavrik, Nikolay V.; Esfahani, Amir Monemian; Rosenbohm, Jordan Daniel; Safa, Bahareh Tajvidi; Minnick, Grayson

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Title: In situ mechanical characterization of a single cell-cell adhesion interface under large strain

Abstract

A method of measuring a stress-strain curve in a cell-cell adhesion interface, the method including: providing a structure including a first movable island supported by a first beam, a second movable island supported by a second beam, and a gap therebetween connected by a pair of cells forming a junction, the pair of cells comprising a cell-cell adhesion interface having an initial length defined by a distance between nuclei of the pair of cells; moving the second movable island with a defined displacement; determining a displacement of the first movable island based on moving the second movable island; calculating a difference between the displacement of the first movable island and the defined displacement of the second movable island based on moving the second movable island; determining an applied strain in the cell-cell adhesion interface between the pair of cells based on the difference divided by the initial length of the cell-cell adhesion interface; calculating a force between the cell-cell adhesion interface of the pair of cells based on the displacement of the first movable island; calculating a stress in the cell-cell adhesion interface between the pair of cells based on the force; and determining the stress-strain curve of the cell-cellmore » « less

Inventors:: Yang, Ruiguo; Lavrik, Nikolay V.; Esfahani, Amir Monemian; Rosenbohm, Jordan Daniel; Safa, Bahareh Tajvidi; Minnick, Grayson

Issue Date:: 2023-12-19

Research Org.:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States); NUtech Ventures, Lincoln, NE (United States)

Sponsoring Org.:: USDOE; National Institutes of Health (NIH); National Science Foundation (NSF)

OSTI Identifier:: 2293996

Patent Number(s):: 11846611

Application Number:: 17/473,090

Assignee:: NUtech Ventures (Lincoln, NE); UT-Battelle, LLC (Oak Ridge, TN)

DOE Contract Number:: AC05-00OR22725; P20 GM113126; P30 GM127200; 1826135

Resource Type:: Patent

Resource Relation:: Patent File Date: 09/13/2021

Country of Publication:: United States

Language:: English

Citation Formats


                    Yang, Ruiguo, Lavrik, Nikolay V., Esfahani, Amir Monemian, Rosenbohm, Jordan Daniel, Safa, Bahareh Tajvidi, and Minnick, Grayson. In situ mechanical characterization of a single cell-cell adhesion interface under large strain.  United States: N. p., 2023. 
        Web.

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                    Yang, Ruiguo, Lavrik, Nikolay V., Esfahani, Amir Monemian, Rosenbohm, Jordan Daniel, Safa, Bahareh Tajvidi, & Minnick, Grayson. In situ mechanical characterization of a single cell-cell adhesion interface under large strain.  United States.

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                    Yang, Ruiguo, Lavrik, Nikolay V., Esfahani, Amir Monemian, Rosenbohm, Jordan Daniel, Safa, Bahareh Tajvidi, and Minnick, Grayson. Tue .  
        "In situ mechanical characterization of a single cell-cell adhesion interface under large strain".  United States.  https://www.osti.gov/servlets/purl/2293996.

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@article{osti_2293996,

  title        = {In situ mechanical characterization of a single cell-cell adhesion interface under large strain},

  author       = {Yang, Ruiguo and Lavrik, Nikolay V. and Esfahani, Amir Monemian and Rosenbohm, Jordan Daniel and Safa, Bahareh Tajvidi and Minnick, Grayson},

  abstractNote = {A method of measuring a stress-strain curve in a cell-cell adhesion interface, the method including: providing a structure including a first movable island supported by a first beam, a second movable island supported by a second beam, and a gap therebetween connected by a pair of cells forming a junction, the pair of cells comprising a cell-cell adhesion interface having an initial length defined by a distance between nuclei of the pair of cells; moving the second movable island with a defined displacement; determining a displacement of the first movable island based on moving the second movable island; calculating a difference between the displacement of the first movable island and the defined displacement of the second movable island based on moving the second movable island; determining an applied strain in the cell-cell adhesion interface between the pair of cells based on the difference divided by the initial length of the cell-cell adhesion interface; calculating a force between the cell-cell adhesion interface of the pair of cells based on the displacement of the first movable island; calculating a stress in the cell-cell adhesion interface between the pair of cells based on the force; and determining the stress-strain curve of the cell-cell adhesion interface between the pair of cells by plotting the calculated stress against the applied strain.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2023},

  month        = {12}

}

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A method for the large-scale production of PCBs including a continuous selective adhesion process for creating printed circuit traces providing input to a production line. A roll of printed circuit traces is produced using rolls of flexible substrate, conductive layer, and conductive layer support by applying adhesive between the rolls of flexible substrate and conductive layer, bringing the rolls together, transferring a circuit pattern onto the flexible substrate, curing the adhesive through non-opaque areas of the circuit pattern, and separating the non-bonded areas. The resulting printed circuit traces are applied from the roll to mounts, and circuit components are appliedmore » « less
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Apparatus for pre-stress-straining rod-type specimens in tension for in-situ passive fracture testing

Patent Wang, John Jy-an [Oak Ridge, TN]; Liu, Ken C [Oak Ridge, TN]; Feng, Zhili [Knoxville, TN]

A stress-strain testing apparatus imposes a stress-strain on a specimen while disposed in a controlled environment. Each end of the specimen is fastened to an end cap and a strain gage is attached to the specimen. An adjusting mechanism and a compression element are disposed between the end caps forming a frame for applying forces to the end caps and thereby stress-straining the specimen. The adjusting mechanism may be extended or retracted to increase or decrease the imposed stress-strain on the specimen, and the stress-strain is measured by the strain gage on the specimen while the apparatus is exposed tomore » « less
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Microfluidic electrochemical device and process for chemical imaging and electrochemical analysis at the electrode-liquid interface in-situ

Patent Yu, Xiao-Ying; Liu, Bingwen; Yang, Li; ...

A microfluidic electrochemical device and process are detailed that provide chemical imaging and electrochemical analysis under vacuum at the surface of the electrode-sample or electrode-liquid interface in-situ. The electrochemical device allows investigation of various surface layers including diffuse layers at selected depths populated with, e.g., adsorbed molecules in which chemical transformation in electrolyte solutions occurs.
Full Text Available
Microfluidic electrochemical device and process for chemical imaging and electrochemical analysis at the electrode-liquid interface in-situ

Patent Yu, Xiao-Ying; Liu, Bingwen; Yang, Li; ...

A microfluidic electrochemical device and process are detailed that provide chemical imaging and electrochemical analysis under vacuum at the surface of the electrode-sample or electrode-liquid interface in-situ. The electrochemical device allows investigation of various surface layers including diffuse layers at selected depths populated with, e.g., adsorbed molecules in which chemical transformation in electrolyte solutions occurs.
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Title: In situ mechanical characterization of a single cell-cell adhesion interface under large strain

Abstract

Citation Formats

Tumor progression: Small GTPases and loss of cell-cell adhesion journal, April 2003

Evaluating the effective shear modulus of the cytoplasm in cultured myoblasts subjected to compression using an inverse finite element method journal, October 2011

Basal-to-apical cadherin flow at cell junctions journal, December 2006

Soft inclusion in a confined fluctuating active gel journal, March 2018

Organization and execution of the epithelial polarity programme journal, March 2014

Alveolar expansion imaged by optical sectioning microscopy journal, September 2007

Measurement of Mechanical Tension at cell-cell junctions using two-photon laser ablation journal, January 2016

The minimal cadherin-catenin complex binds to actin filaments under force journal, October 2014

Apparatus and method for material testing of microscale and nanoscale samples patent, July 2010

Viscoelasticity of Tau Proteins Leads to Strain Rate-Dependent Breaking of Microtubules during Axonal Stretch Injury: Predictions from a Mathematical Model journal, March 2014

Mechanical tugging force regulates the size of cell-cell junctions journal, May 2010

Ideal, catch, and slip bonds in cadherin adhesion journal, October 2012

Two-photon polymerization initiators for three-dimensional optical data storage and microfabrication journal, March 1999

Techniques to stimulate and interrogate cell–cell adhesion mechanics journal, April 2018

A practical guide to quantify cell adhesion using single-cell force spectroscopy journal, April 2013

Vinculin phosphorylation differentially regulates mechanotransduction at cell–cell and cell–matrix adhesions journal, April 2014

Characterizing the mechanics of cultured cell monolayers journal, September 2012

Tissue Organization by Cadherin Adhesion Molecules: Dynamic Molecular and Cellular Mechanisms of Morphogenetic Regulation journal, April 2011

Size- and speed-dependent mechanical behavior in living mammalian cytoplasm journal, August 2017

Stable Force Balance between Epithelial Cells Arises from F-Actin Turnover journal, December 2015

Two-Component Polymer Scaffolds for Controlled Three-Dimensional Cell Culture journal, January 2011

Linking E-cadherin mechanotransduction to cell metabolism through force-mediated activation of AMPK journal, May 2017

Nanoscale architecture of cadherin-based cell adhesions journal, December 2016

Stress micro mechanical test cell, device, system and methods patent, August 2013

α-Catenin stabilises Cadherin–Catenin complexes and modulates actomyosin dynamics to allow pulsatile apical contraction journal, November 2016

Resolving the molecular mechanism of cadherin catch bond formation journal, June 2014

Mechanical Feedback through E-Cadherin Promotes Direction Sensing during Collective Cell Migration journal, May 2014

Cadherin-dependent mechanotransduction depends on ligand identity but not affinity journal, January 2012

Force measurements in E-cadherin–mediated cell doublets reveal rapid adhesion strengthened by actin cytoskeleton remodeling through Rac and Cdc42 journal, December 2004

Acto-myosin cytoskeleton dependent viscosity and shear-thinning behavior of the amoeba cytoplasm journal, February 2005

Pattern Formation in Active Fluids journal, January 2011

Effect of stretch on structural integrity and micromechanics of human alveolar epithelial cell monolayers exposed to thrombin journal, June 2006

Single-molecule analysis of cadherin-mediated cell-cell adhesion journal, January 2006

Review and perspective on soft matter modeling in cellular mechanobiology: cell contact, adhesion, mechanosensing, and motility journal, November 2017

Hydraulic fracture during epithelial stretching journal, February 2015

Chapter 19 Mechanical Response of Cytoskeletal Networks book, December 2008

The desmoplakin–intermediate filament linkage regulates cell mechanics journal, November 2017

In vivo measurement of skin surface strain and sub-surface layer deformation induced by natural tissue stretching journal, September 2016

Analysis of Temporal Shear Stress Gradients During the Onset Phase of Flow Over a Backward-Facing Step journal, April 2001

Gene regulation by mechanotransduction in fibroblasts journal, October 2007

Regulation of cadherin-mediated adhesion in morphogenesis journal, July 2005

E-cadherin supports steady-state Rho signaling at the epithelial zonula adherens journal, October 2013

Cell–cell adhesion in the normal ovary and ovarian tumors of epithelial origin; an exception to the rule journal, April 2003

Quantitative methods for analyzing cell–cell adhesion in development journal, May 2015

Multidimensional traction force microscopy reveals out-of-plane rotational moments about focal adhesions journal, December 2012

Effects of different types of fluid shear stress on endothelial cell proliferation and survival journal, February 2007

New techniques for isolation of single prokaryotic cells journal, December 2000

3D printed mechanical testing device for micro-scale material specimens patent, March 2023

Device and method for determining mechanical properties of nanomaterials patent, August 2022

Stress Micro Mechanical Test Cell, Device, System and Methods patent-application, April 2010

Bistable front dynamics in a contractile medium: Travelling wave fronts and cortical advection define stable zones of RhoA signaling at epithelial adherens junctions journal, March 2017

Quantifying Forces Mediated by Integral Tight Junction Proteins in Cell–Cell Adhesion journal, January 2008

Elastic Fully Three-dimensional Microstructure Scaffolds for Cell Force Measurements journal, February 2010

Tensile Forces and Mechanotransduction at Cell–Cell Junctions journal, April 2018

Desmosomes in Human Disease journal, January 2018

Understanding the Counterintuitive Phenomenon of Catch Bonds journal, February 2007

Probing Intercellular Interactions between Vascular Endothelial Cadherin Pairs at Single-molecule Resolution and in Living Cells journal, May 2006

Stress relaxation in epithelial monolayers is controlled by the actomyosin cortex journal, May 2019

Collective cell guidance by cooperative intercellular forces journal, May 2011

Shear Rate-Dependence of Leukocyte Cytoplasmic Viscosity book, January 1994

Mechanics of the Mitral Valve Strut Chordae Insertion Region journal, June 2010

Tissue Regeneration from Mechanical Stretching of Cell–Cell Adhesion journal, November 2019

Embryonic Heart and Skin Defects in Mice Lacking Plakoglobin journal, December 1996

Cadherins in embryonic and neural morphogenesis journal, November 2000

Vinculin forms a directionally asymmetric catch bond with F-actin journal, August 2017

The dynamic mechanical properties of cellularised aggregates journal, October 2016

In Vitro Dynamic Strain Behavior of the Mitral Valve Posterior Leaflet journal, January 2005

Differential effects of equiaxial and uniaxial strain on mesenchymal stem cells journal, October 2004

Tumor progression: Small GTPases and loss of cell-cell adhesion
journal, April 2003

Evaluating the effective shear modulus of the cytoplasm in cultured myoblasts subjected to compression using an inverse finite element method
journal, October 2011

Basal-to-apical cadherin flow at cell junctions
journal, December 2006

Soft inclusion in a confined fluctuating active gel
journal, March 2018

Organization and execution of the epithelial polarity programme
journal, March 2014

Alveolar expansion imaged by optical sectioning microscopy
journal, September 2007

Measurement of Mechanical Tension at cell-cell junctions using two-photon laser ablation
journal, January 2016

The minimal cadherin-catenin complex binds to actin filaments under force
journal, October 2014

Apparatus and method for material testing of microscale and nanoscale samples
patent, July 2010

Viscoelasticity of Tau Proteins Leads to Strain Rate-Dependent Breaking of Microtubules during Axonal Stretch Injury: Predictions from a Mathematical Model
journal, March 2014

Mechanical tugging force regulates the size of cell-cell junctions
journal, May 2010

Ideal, catch, and slip bonds in cadherin adhesion
journal, October 2012

Two-photon polymerization initiators for three-dimensional optical data storage and microfabrication
journal, March 1999

Techniques to stimulate and interrogate cell–cell adhesion mechanics
journal, April 2018

A practical guide to quantify cell adhesion using single-cell force spectroscopy
journal, April 2013

Vinculin phosphorylation differentially regulates mechanotransduction at cell–cell and cell–matrix adhesions
journal, April 2014

Characterizing the mechanics of cultured cell monolayers
journal, September 2012

Tissue Organization by Cadherin Adhesion Molecules: Dynamic Molecular and Cellular Mechanisms of Morphogenetic Regulation
journal, April 2011

Size- and speed-dependent mechanical behavior in living mammalian cytoplasm
journal, August 2017

Stable Force Balance between Epithelial Cells Arises from F-Actin Turnover
journal, December 2015

Two-Component Polymer Scaffolds for Controlled Three-Dimensional Cell Culture
journal, January 2011

Linking E-cadherin mechanotransduction to cell metabolism through force-mediated activation of AMPK
journal, May 2017

Nanoscale architecture of cadherin-based cell adhesions
journal, December 2016

Stress micro mechanical test cell, device, system and methods
patent, August 2013

α-Catenin stabilises Cadherin–Catenin complexes and modulates actomyosin dynamics to allow pulsatile apical contraction
journal, November 2016

Resolving the molecular mechanism of cadherin catch bond formation
journal, June 2014

Mechanical Feedback through E-Cadherin Promotes Direction Sensing during Collective Cell Migration
journal, May 2014

Cadherin-dependent mechanotransduction depends on ligand identity but not affinity
journal, January 2012

Force measurements in E-cadherin–mediated cell doublets reveal rapid adhesion strengthened by actin cytoskeleton remodeling through Rac and Cdc42
journal, December 2004

Acto-myosin cytoskeleton dependent viscosity and shear-thinning behavior of the amoeba cytoplasm
journal, February 2005

Pattern Formation in Active Fluids
journal, January 2011

Effect of stretch on structural integrity and micromechanics of human alveolar epithelial cell monolayers exposed to thrombin
journal, June 2006

Single-molecule analysis of cadherin-mediated cell-cell adhesion
journal, January 2006

Review and perspective on soft matter modeling in cellular mechanobiology: cell contact, adhesion, mechanosensing, and motility
journal, November 2017

Hydraulic fracture during epithelial stretching
journal, February 2015

Chapter 19 Mechanical Response of Cytoskeletal Networks
book, December 2008

The desmoplakin–intermediate filament linkage regulates cell mechanics
journal, November 2017

In vivo measurement of skin surface strain and sub-surface layer deformation induced by natural tissue stretching
journal, September 2016

Analysis of Temporal Shear Stress Gradients During the Onset Phase of Flow Over a Backward-Facing Step
journal, April 2001

Gene regulation by mechanotransduction in fibroblasts
journal, October 2007

Regulation of cadherin-mediated adhesion in morphogenesis
journal, July 2005

E-cadherin supports steady-state Rho signaling at the epithelial zonula adherens
journal, October 2013

Cell–cell adhesion in the normal ovary and ovarian tumors of epithelial origin; an exception to the rule
journal, April 2003

Quantitative methods for analyzing cell–cell adhesion in development
journal, May 2015

Multidimensional traction force microscopy reveals out-of-plane rotational moments about focal adhesions
journal, December 2012

Effects of different types of fluid shear stress on endothelial cell proliferation and survival
journal, February 2007

New techniques for isolation of single prokaryotic cells
journal, December 2000

3D printed mechanical testing device for micro-scale material specimens
patent, March 2023

Device and method for determining mechanical properties of nanomaterials
patent, August 2022

Stress Micro Mechanical Test Cell, Device, System and Methods
patent-application, April 2010

Bistable front dynamics in a contractile medium: Travelling wave fronts and cortical advection define stable zones of RhoA signaling at epithelial adherens junctions
journal, March 2017

Quantifying Forces Mediated by Integral Tight Junction Proteins in Cell–Cell Adhesion
journal, January 2008

Elastic Fully Three-dimensional Microstructure Scaffolds for Cell Force Measurements
journal, February 2010

Tensile Forces and Mechanotransduction at Cell–Cell Junctions
journal, April 2018

Desmosomes in Human Disease
journal, January 2018

Understanding the Counterintuitive Phenomenon of Catch Bonds
journal, February 2007

Probing Intercellular Interactions between Vascular Endothelial Cadherin Pairs at Single-molecule Resolution and in Living Cells
journal, May 2006

Stress relaxation in epithelial monolayers is controlled by the actomyosin cortex
journal, May 2019

Collective cell guidance by cooperative intercellular forces
journal, May 2011

Shear Rate-Dependence of Leukocyte Cytoplasmic Viscosity
book, January 1994

Mechanics of the Mitral Valve Strut Chordae Insertion Region
journal, June 2010

Tissue Regeneration from Mechanical Stretching of Cell–Cell Adhesion
journal, November 2019

Embryonic Heart and Skin Defects in Mice Lacking Plakoglobin
journal, December 1996

Cadherins in embryonic and neural morphogenesis
journal, November 2000

Vinculin forms a directionally asymmetric catch bond with F-actin
journal, August 2017

The dynamic mechanical properties of cellularised aggregates
journal, October 2016

In Vitro Dynamic Strain Behavior of the Mitral Valve Posterior Leaflet
journal, January 2005

Differential effects of equiaxial and uniaxial strain on mesenchymal stem cells
journal, October 2004