Genetically engineered foot and mouth disease virus and related proteins, polynucleotides, compositions, methods and systems
Abstract
Genetically engineered Foot and Mouth Disease Virus (FMDV) and related engineered proteins and polynucleotides, nanolipoprotein particles, compositions, methods and systems are described. The genetically engineered FMDV is modified by the strategic insertion of a protein tag into select regions of the FMDV genome which encode viral proteins that are exposed on the surface of the FMDV viral capsid. The inserted protein tag is displayed as a decoration or attachment on the viral capsid surface.
- Inventors:
- Issue Date:
- Research Org.:
- Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States); US Dept. of Agriculture (USDA), Washington, DC (United States); Univ. of Connecticut, Farmington, CT (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 2293853
- Patent Number(s):
- 11813320
- Application Number:
- 17/176,989
- Assignee:
- Lawrence Livermore National Security, LLC (Livermore, CA); The United States of America, Represented by the Secretary of Agriculture (Washington, DC); University of Connecticut (Farmington, CT)
- DOE Contract Number:
- AC52-07NA27344
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 02/16/2021
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Rieder, Aida E., De Los Santos, Teresa B., Rodriguez, Luis L., Rai, Devendra, Diaz-San Segundo, Fayna C., and Hoeprich, Paul D. Genetically engineered foot and mouth disease virus and related proteins, polynucleotides, compositions, methods and systems. United States: N. p., 2023.
Web.
Rieder, Aida E., De Los Santos, Teresa B., Rodriguez, Luis L., Rai, Devendra, Diaz-San Segundo, Fayna C., & Hoeprich, Paul D. Genetically engineered foot and mouth disease virus and related proteins, polynucleotides, compositions, methods and systems. United States.
Rieder, Aida E., De Los Santos, Teresa B., Rodriguez, Luis L., Rai, Devendra, Diaz-San Segundo, Fayna C., and Hoeprich, Paul D. Tue .
"Genetically engineered foot and mouth disease virus and related proteins, polynucleotides, compositions, methods and systems". United States. https://www.osti.gov/servlets/purl/2293853.
@article{osti_2293853,
title = {Genetically engineered foot and mouth disease virus and related proteins, polynucleotides, compositions, methods and systems},
author = {Rieder, Aida E. and De Los Santos, Teresa B. and Rodriguez, Luis L. and Rai, Devendra and Diaz-San Segundo, Fayna C. and Hoeprich, Paul D.},
abstractNote = {Genetically engineered Foot and Mouth Disease Virus (FMDV) and related engineered proteins and polynucleotides, nanolipoprotein particles, compositions, methods and systems are described. The genetically engineered FMDV is modified by the strategic insertion of a protein tag into select regions of the FMDV genome which encode viral proteins that are exposed on the surface of the FMDV viral capsid. The inserted protein tag is displayed as a decoration or attachment on the viral capsid surface.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2023},
month = {11}
}
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
Immunostimulatory nanoparticles and related compositions, methods and systems
patent, November 2014
- Hoeprich, Jr., Paul D.; Fischer, Nicholas O.; Blanchette, Craig D.
- US Patent Document 8,889,623
Foot-and-mouth disease virus (FMDV) causes an acute disease that can be lethal for adult laboratory mice
journal, February 2005
- Salguero, Francisco J.; Sánchez-Martín, Miguel A.; Díaz-San Segundo, Fayna
- Virology, Vol. 332, Issue 1
Nanolipoprotein particles and related compositions, methods and systems
patent, November 2014
- Hoeprich, Jr., Paul D.; Fischer, Nicholas O.; Mason, Peter
- US Patent Document 8,883,729
Genetically engineered Foot and Mouth Disease Virus and related proteins, polynucleotides, compositions, methods and systems
patent, March 2021
- Rieder, Aida E.; De Los Santos, Teresa B.; Rodriguez, Luis L.
- US Patent Document 10,953,085
Genetically Engineered Foot and Mouth Disease Virus and Related Proteins, Polynucleotides, Compositions, Methods and Systems
patent-application, November 2018
- Rieder, Aida E.; De Los Santos, Teresa B.; Rodriguez, Luis L.
- 15/590918; 20180326038