Conversion of S-lignin compounds to useful intermediates
Abstract
The present disclosure relates to a genetically modified microbial cell that includes a first genetic modification resulting in the expression of an exogenous vanillate demethylase, such that the microbial cell is capable of metabolizing an S-lignin decomposition product and producing 2-pyrone-4,6-dicarboxylate (PDC).
- Inventors:
- Issue Date:
- Research Org.:
- National Renewable Energy Laboratory (NREL), Golden, CO (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 2293820
- Patent Number(s):
- 11807873
- Application Number:
- 17/504,901
- Assignee:
- Alliance for Sustainable Energy, LLC (Golden, CO)
- DOE Contract Number:
- AC36-08GO28308
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 10/19/2021
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Johnson, Christopher W., Zimont Werner, Allison Jean, Beckham, Gregg Tyler, and Notonier, Sandra Fabienne. Conversion of S-lignin compounds to useful intermediates. United States: N. p., 2023.
Web.
Johnson, Christopher W., Zimont Werner, Allison Jean, Beckham, Gregg Tyler, & Notonier, Sandra Fabienne. Conversion of S-lignin compounds to useful intermediates. United States.
Johnson, Christopher W., Zimont Werner, Allison Jean, Beckham, Gregg Tyler, and Notonier, Sandra Fabienne. Tue .
"Conversion of S-lignin compounds to useful intermediates". United States. https://www.osti.gov/servlets/purl/2293820.
@article{osti_2293820,
title = {Conversion of S-lignin compounds to useful intermediates},
author = {Johnson, Christopher W. and Zimont Werner, Allison Jean and Beckham, Gregg Tyler and Notonier, Sandra Fabienne},
abstractNote = {The present disclosure relates to a genetically modified microbial cell that includes a first genetic modification resulting in the expression of an exogenous vanillate demethylase, such that the microbial cell is capable of metabolizing an S-lignin decomposition product and producing 2-pyrone-4,6-dicarboxylate (PDC).},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Nov 07 00:00:00 EST 2023},
month = {Tue Nov 07 00:00:00 EST 2023}
}
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
Innovative Chemicals and Materials from Bacterial Aromatic Catabolic Pathways
journal, June 2019
- Johnson, Christopher W.; Salvachúa, Davinia; Rorrer, Nicholas A.
- Joule, Vol. 3, Issue 6
Polyesters of 2-Pyrone-4,6-Dicarboxylic Acid (PDC) Obtained from a Metabolic Intermediate of Lignin
journal, November 2007
- Michinobu, Tsuyoshi; Hishida, Masakiyo; Sato, Masae
- Polymer Journal, Vol. 40, Issue 1
Aromatic catabolic pathway selection for optimal production of pyruvate and lactate from lignin
journal, March 2015
- Johnson, Christopher W.; Beckham, Gregg T.
- Metabolic Engineering, Vol. 28
Characterization of the 4-Carboxy-4-Hydroxy-2-Oxoadipate Aldolase Gene and Operon Structure of the Protocatechuate 4,5-Cleavage Pathway Genes in Sphingomonas paucimobilis SYK-6
journal, January 2003
- Hara, Hirofumi; Masai, Eiji; Miyauchi, Keisuke
- Journal of Bacteriology, Vol. 185, Issue 1
Expression and purification of nuclease-free protocatechuate 3,4-dioxygenase for prolonged single-molecule fluorescence imaging
journal, September 2018
- Senavirathne, Gayan; Lopez, Miguel A.; Messer, Ryan
- Analytical Biochemistry, Vol. 556
Glucose-Free cis , cis -Muconic Acid Production via New Metabolic Designs Corresponding to the Heterogeneity of Lignin
journal, November 2017
- Sonoki, Tomonori; Takahashi, Kenji; Sugita, Haruka
- ACS Sustainable Chemistry & Engineering, Vol. 6, Issue 1
Broad host range vectors for stable genomic library construction
journal, January 2006
- Lynch, Michael D.; Gill, Ryan T.
- Biotechnology and Bioengineering, Vol. 94, Issue 1
Opportunities and challenges in biological lignin valorization
journal, December 2016
- Beckham, Gregg T.; Johnson, Christopher W.; Karp, Eric M.
- Current Opinion in Biotechnology, Vol. 42
Metabolic engineering of Pseudomonas putida for increased polyhydroxyalkanoate production from lignin
journal, January 2020
- Salvachúa, Davinia; Rydzak, Thomas; Auwae, Raquel
- Microbial Biotechnology, Vol. 13, Issue 1
Functional Annotation of LigU as a 1,3-Allylic Isomerase during the Degradation of Lignin in the Protocatechuate 4,5-Cleavage Pathway from the Soil Bacterium Sphingobium sp. SYK-6
journal, April 2018
- Hogancamp, Tessily N.; Raushel, Frank M.
- Biochemistry, Vol. 57, Issue 19
Substrate Range and Genetic Analysis of Acinetobacter Vanillate Demethylase
journal, March 2000
- Morawski, B.; Segura, A.; Ornston, L. N.
- Journal of Bacteriology, Vol. 182, Issue 5
Lignin depolymerization by fungal secretomes and a microbial sink
journal, January 2016
- Salvachúa, Davinia; Katahira, Rui; Cleveland, Nicholas S.
- Green Chemistry, Vol. 18, Issue 22
Towards lignin consolidated bioprocessing: simultaneous lignin depolymerization and product generation by bacteria
journal, January 2015
- Salvachúa, Davinia; Karp, Eric M.; Nimlos, Claire T.
- Green Chemistry, Vol. 17, Issue 11
Bioprocess development for muconic acid production from aromatic compounds and lignin
journal, January 2018
- Salvachúa, Davinia; Johnson, Christopher W.; Singer, Christine A.
- Green Chemistry, Vol. 20, Issue 21
Funneling aromatic products of chemically depolymerized lignin into 2-pyrone-4-6-dicarboxylic acid with Novosphingobium aromaticivorans
journal, January 2019
- Perez, Jose M.; Kontur, Wayne S.; Alherech, Manar
- Green Chemistry, Vol. 21, Issue 6
Genetic engineering of Pseudomonas putida KT2440 for rapid and high-yield production of vanillin from ferulic acid
journal, October 2013
- Graf, Nadja; Altenbuchner, Josef
- Applied Microbiology and Biotechnology, Vol. 98, Issue 1
Characterization of the 3-O-Methylgallate Dioxygenase Gene and Evidence of Multiple 3-O-Methylgallate Catabolic Pathways in Sphingomonas paucimobilis SYK-6
journal, July 2004
- Kasai, D.; Masai, E.; Miyauchi, K.
- Journal of Bacteriology, Vol. 186, Issue 15
Eliminating a global regulator of carbon catabolite repression enhances the conversion of aromatic lignin monomers to muconate in Pseudomonas putida KT2440
journal, December 2017
- Johnson, Christopher W.; Abraham, Paul E.; Linger, Jeffrey G.
- Metabolic Engineering Communications, Vol. 5
Reactivity of Toluate Dioxygenase with Substituted Benzoates and Dioxygen
journal, August 2002
- Ge, Yong; Vaillancourt, Frédéric H.; Agar, Nathalie Y. R.
- Journal of Bacteriology, Vol. 184, Issue 15
A Tetrahydrofolate-Dependent O-Demethylase, LigM, Is Crucial for Catabolism of Vanillate and Syringate in Sphingomonas paucimobilis SYK-6
journal, March 2005
- Abe, T.; Masai, E.; Miyauchi, K.
- Journal of Bacteriology, Vol. 187, Issue 6, p. 2030-2037
Exploring the Selective Demethylation of Aryl Methyl Ethers with a Pseudomonas Rieske Monooxygenase
journal, December 2018
- Lanfranchi, Elisa; Trajković, Miloš; Barta, Katalin
- ChemBioChem, Vol. 20, Issue 1
A bacterial aromatic aldehyde dehydrogenase critical for the efficient catabolism of syringaldehyde
journal, March 2017
- Kamimura, Naofumi; Goto, Takayuki; Takahashi, Kenji
- Scientific Reports, Vol. 7, Issue 1
Cloning and sequencing of Pseudomonas genes encoding vanillate demethylase.
journal, October 1988
- Brunel, F.; Davison, J.
- Journal of Bacteriology, Vol. 170, Issue 10
2-pyrone-4,6-dicarboxylic acid, a catabolite of gallic acids in Pseudomonas species
journal, December 1982
- Kersten, P. J.; Dagley, S.; Whittaker, J. W.
- Journal of Bacteriology, Vol. 152, Issue 3
Characterization of Sphingomonas paucimobilis SYK-6 genes involved in degradation of lignin-related compounds
journal, October 1999
- Masai, E.; Katayama, Y.; Nishikawa, S.
- Journal of Industrial Microbiology and Biotechnology, Vol. 23, Issue 4-5
Outer membrane vesicles catabolize lignin-derived aromatic compounds in Pseudomonas putida KT2440
journal, April 2020
- Salvachúa, Davinia; Werner, Allison Z.; Pardo, Isabel
- Proceedings of the National Academy of Sciences, Vol. 117, Issue 17
Lignin valorization through integrated biological funneling and chemical catalysis
journal, August 2014
- Linger, J. G.; Vardon, D. R.; Guarnieri, M. T.
- Proceedings of the National Academy of Sciences, Vol. 111, Issue 33, p. 12013-12018
Comprehensive proteome analysis of the response of Pseudomonas putida KT2440 to the flavor compound vanillin
journal, September 2014
- Simon, Oliver; Klaiber, Iris; Huber, Armin
- Journal of Proteomics, Vol. 109
Development of a high efficiency integration system and promoter library for rapid modification of Pseudomonas putida KT2440
journal, December 2017
- Elmore, Joshua R.; Furches, Anna; Wolff, Gara N.
- Metabolic Engineering Communications, Vol. 5
A Novel Tetrahydrofolate-Dependent O-Demethylase Gene Is Essential for Growth of Sphingomonas paucimobilis SYK-6 with Syringate
journal, April 2004
- Masai, E.; Sasaki, M.; Minakawa, Y.
- Journal of Bacteriology, Vol. 186, Issue 9
Enhancing muconic acid production from glucose and lignin-derived aromatic compounds via increased protocatechuate decarboxylase activity
journal, December 2016
- Johnson, Christopher W.; Salvachúa, Davinia; Khanna, Payal
- Metabolic Engineering Communications, Vol. 3
Residue mutations and their impact on protein structure and function: detecting beneficial and pathogenic changes
journal, January 2013
- Studer, Romain A.; Dessailly, Benoit H.; Orengo, Christine A.
- Biochemical Journal, Vol. 449, Issue 3
Unravelling the gallic acid degradation pathway in bacteria: the gal cluster from Pseudomonas putida: Aerobic gallic acid degradation
journal, November 2010
- Nogales, Juan; Canales, Ángeles; Jiménez-Barbero, Jesús
- Molecular Microbiology, Vol. 79, Issue 2
Expression and Substrate Range of Streptomyces Vanillate Demethylase
journal, January 2014
- Nishimura, Motohiro; Nishimura, Yoshio; Abe, Chinatsu
- Biological and Pharmaceutical Bulletin, Vol. 37, Issue 9
Degradation of substituted mandelic acids by meta fission reactions.
journal, August 1987
- Sze, I. S.; Dagley, S.
- Journal of Bacteriology, Vol. 169, Issue 8
Method for analyzing and synthesizing functional polypeptide sequences for assembly into enhanced or multi-functional proteins
patent, August 1990
- Jasin, Maria; Schimmel, Paul
- US Patent Document 4,952,501
Formic-acid-induced depolymerization of oxidized lignin to aromatics
journal, November 2014
- Rahimi, Alireza; Ulbrich, Arne; Coon, Joshua J.
- Nature, Vol. 515, Issue 7526, p. 249-252
Adipic acid production from lignin
journal, January 2015
- Vardon, Derek R.; Franden, Mary Ann; Johnson, Christopher W.
- Energy & Environmental Science, Vol. 8, Issue 2
Characterization of 3-Ketosteroid 9α-Hydroxylase, a Rieske Oxygenase in the Cholesterol Degradation Pathway of Mycobacterium tuberculosis
journal, February 2009
- Capyk, Jenna K.; D'Angelo, Igor; Strynadka, Natalie C.
- Journal of Biological Chemistry, Vol. 284, Issue 15
Functional coupling between vanillate- O -demethylase and formaldehyde detoxification pathway
journal, December 2005
- Hibi, Makoto; Sonoki, Tomonori; Mori, Hideo
- FEMS Microbiology Letters, Vol. 253, Issue 2
Characterizing the Promiscuity of LigAB, a Lignin Catabolite Degrading Extradiol Dioxygenase from Sphingomonas paucimobilis SYK-6
journal, September 2013
- Barry, Kevin P.; Taylor, Erika A.
- Biochemistry, Vol. 52, Issue 38
Characterization of the Gallate Dioxygenase Gene: Three Distinct Ring Cleavage Dioxygenases Are Involved in Syringate Degradation by Sphingomonas paucimobilis SYK-6
journal, July 2005
- Kasai, D.; Masai, E.; Miyauchi, K.
- Journal of Bacteriology, Vol. 187, Issue 15
Molecular Characterization of the Gallate Dioxygenase from Pseudomonas putida KT2440
journal, July 2005
- Nogales, Juan; Canales, Ángeles; Jiménez-Barbero, Jesús
- Journal of Biological Chemistry, Vol. 280, Issue 42