Molecular entrapment via homopolymer self-assembly

Scott, Evan A.; Du, Fanfan; Qiao, Baofu; de la Cruz, Monica Olvera

Title: Molecular entrapment via homopolymer self-assembly

Abstract

The present invention provides novel nanostructures comprising solution of PPSU₂₀. Methods of preparing the novel PPSU nanostructures, and applications of such nanostructures are also provided.

Inventors:: Scott, Evan A.; Du, Fanfan; Qiao, Baofu; de la Cruz, Monica Olvera

Issue Date:: 2023-10-31

Research Org.:: Northwestern Univ., Evanston, IL (United States)

Sponsoring Org.:: USDOE; National Institutes of Health (NIH), Bethesda, MD (United States)

OSTI Identifier:: 2293796

Patent Number(s):: 11801229

Application Number:: 16/942,228

Assignee:: Northwestern University (Evanston, IL)

DOE Contract Number:: 132390-01; 1DP2HL; FG02-08ER46539

Resource Type:: Patent

Resource Relation:: Patent File Date: 07/29/2020

Country of Publication:: United States

Language:: English

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                    Scott, Evan A., Du, Fanfan, Qiao, Baofu, and de la Cruz, Monica Olvera. Molecular entrapment via homopolymer self-assembly.  United States: N. p., 2023. 
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                    Scott, Evan A., Du, Fanfan, Qiao, Baofu, & de la Cruz, Monica Olvera. Molecular entrapment via homopolymer self-assembly.  United States.

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                    Scott, Evan A., Du, Fanfan, Qiao, Baofu, and de la Cruz, Monica Olvera. Tue .  
        "Molecular entrapment via homopolymer self-assembly".  United States.  https://www.osti.gov/servlets/purl/2293796.

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@article{osti_2293796,

  title        = {Molecular entrapment via homopolymer self-assembly},

  author       = {Scott, Evan A. and Du, Fanfan and Qiao, Baofu and de la Cruz, Monica Olvera},

  abstractNote = {The present invention provides novel nanostructures comprising solution of PPSU20. Methods of preparing the novel PPSU nanostructures, and applications of such nanostructures are also provided.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2023},

  month        = {10}

}

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Works referenced in this record:

Lipid-based nanovesicles for nanomedicine
journal, January 2016

Grimaldi, N.; Andrade, F.; Segovia, N.
Chemical Society Reviews, Vol. 45, Issue 23
https://doi.org/10.1039/C6CS00409A

Initiation of the adaptive immune response to Mycobacterium tuberculosis depends on antigen production in the local lymph node, not the lungs
journal, December 2007

Wolf, Andrea J.; Desvignes, Ludovic; Linas, Beth
Journal of Experimental Medicine, Vol. 205, Issue 1
https://doi.org/10.1084/jem.20071367

Mass spectrometric mapping of fibrinogen conformations at poly(ethylene terephthalate) interfaces☆
journal, September 2007

Scott, E.; Elbert, D.
Biomaterials, Vol. 28, Issue 27
https://doi.org/10.1016/j.biomaterials.2007.05.022

Liposome production by microfluidics: potential and limiting factors
journal, May 2016

Carugo, Dario; Bottaro, Elisabetta; Owen, Joshua
Scientific Reports, Vol. 6, Issue 1
https://doi.org/10.1038/srep25876

Precision Intracellular Delivery Based on Optofluidic Polymersome Rupture
journal, August 2012

Vasdekis, Andreas E.; Scott, Evan A.; O’Neil, Conlin P.
ACS Nano, Vol. 6, Issue 9
https://doi.org/10.1021/nn302122h

Biodegradable STING agonist nanoparticles for enhanced cancer immunotherapy
journal, February 2018

Wilson, David R.; Sen, Rupashree; Sunshine, Joel C.
Nanomedicine: Nanotechnology, Biology and Medicine, Vol. 14, Issue 2
https://doi.org/10.1016/j.nano.2017.10.013

Stable Isotope Labeling Tandem Mass Spectrometry (SILT): Integration with Peptide Identification and Extension to Data-Dependent Scans
journal, September 2008

Elbert, Donald L.; Mawuenyega, Kwasi G.; Scott, Evan A.
Journal of Proteome Research, Vol. 7, Issue 10
https://doi.org/10.1021/pr800386u

Liquid worm-like and proto-micelles: water solubilization in amphiphile–oil solutions
journal, January 2018

Qiao, Baofu; Littrell, Kenneth C.; Ellis, Ross J.
Physical Chemistry Chemical Physics, Vol. 20, Issue 18
https://doi.org/10.1039/C8CP00600H

Structure of the cross-β spine of amyloid-like fibrils
journal, June 2005

Nelson, Rebecca; Sawaya, Michael R.; Balbirnie, Melinda
Nature, Vol. 435, Issue 7043
https://doi.org/10.1038/nature03680

CHARMM36m: an improved force field for folded and intrinsically disordered proteins
journal, November 2016

Huang, Jing; Rauscher, Sarah; Nawrocki, Grzegorz
Nature Methods, Vol. 14, Issue 1
https://doi.org/10.1038/nmeth.4067

PEG-SS-PPS: Reduction-Sensitive Disulfide Block Copolymer Vesicles for Intracellular Drug Delivery
journal, June 2007

Cerritelli, Simona; Velluto, Diana; Hubbell, Jeffrey A.
Biomacromolecules, Vol. 8, Issue 6
https://doi.org/10.1021/bm070085x

Settle: An analytical version of the SHAKE and RATTLE algorithm for rigid water models
journal, October 1992

Miyamoto, Shuichi; Kollman, Peter A.
Journal of Computational Chemistry, Vol. 13, Issue 8
https://doi.org/10.1002/jcc.540130805

Supramolecular polymer networks: hydrogels and bulk materials
journal, January 2016

Voorhaar, Lenny; Hoogenboom, Richard
Chemical Society Reviews, Vol. 45, Issue 14
https://doi.org/10.1039/C6CS00130K

A New Initiator System for the Living Thiiranes Ring-Opening Polymerization: A Way toward Star-Shaped Polythiiranes
journal, June 1999

Nicol, E.; Bonnans-Plaisance, C.; Levesque, G.
Macromolecules, Vol. 32, Issue 13
https://doi.org/10.1021/ma9900434

Chemisorbed poly(propylene sulphide)-based copolymers resist biomolecular interactions
journal, March 2003

Bearinger, J. P.; Terrettaz, S.; Michel, R.
Nature Materials, Vol. 2, Issue 4
https://doi.org/10.1038/nmat851

A smooth particle mesh Ewald method
journal, November 1995

Essmann, Ulrich; Perera, Lalith; Berkowitz, Max L.
The Journal of Chemical Physics, Vol. 103, Issue 19
https://doi.org/10.1063/1.470117

Sustained delivery by a cyclodextrin material-based nanocarrier potentiates antiatherosclerotic activity of rapamycin via selectively inhibiting mTORC1 in mice
journal, August 2016

Dou, Yin; Guo, Jiawei; Chen, Yue
Journal of Controlled Release, Vol. 235
https://doi.org/10.1016/j.jconrel.2016.05.049

Surface Engineered Polymersomes for Enhanced Modulation of Dendritic Cells During Cardiovascular Immunotherapy
journal, August 2019

Yi, Sijia; Zhang, Xiaohan; Sangji, M. Hussain
Advanced Functional Materials, Vol. 29, Issue 42
https://doi.org/10.1002/adfm.201904399

Biological Photothermal Nanodots Based on Self-Assembly of Peptide–Porphyrin Conjugates for Antitumor Therapy
journal, January 2017

Zou, Qianli; Abbas, Manzar; Zhao, Luyang
Journal of the American Chemical Society, Vol. 139, Issue 5
https://doi.org/10.1021/jacs.6b11382

Polymersome carriers: From self-assembly to siRNA and protein therapeutics
journal, March 2009

Christian, David A.; Cai, Shenshen; Bowen, Diana M.
European Journal of Pharmaceutics and Biopharmaceutics, Vol. 71, Issue 3
https://doi.org/10.1016/j.ejpb.2008.09.025

Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement
journal, March 2017

Butawan, Matthew; Benjamin, Rodney; Bloomer, Richard
Nutrients, Vol. 9, Issue 3
https://doi.org/10.3390/nu9030290

Dual Carfilzomib and Doxorubicin–Loaded Liposomal Nanoparticles for Synergistic Efficacy in Multiple Myeloma
journal, July 2016

Ashley, Jonathan D.; Quinlan, Charissa J.; Schroeder, Valerie A.
Molecular Cancer Therapeutics, Vol. 15, Issue 7
https://doi.org/10.1158/1535-7163.MCT-15-0867

Perspective on the Martini model
journal, January 2013

Marrink, Siewert J.; Tieleman, D. Peter
Chemical Society Reviews, Vol. 42, Issue 16
https://doi.org/10.1039/c3cs60093a

Induction of Mycobacterium Tuberculosis Lipid-Specific T Cell Responses by Pulmonary Delivery of Mycolic Acid-Loaded Polymeric Micellar Nanocarriers
journal, November 2018

Shang, Shaobin; Kats, Dina; Cao, Liang
Frontiers in Immunology, Vol. 9
https://doi.org/10.3389/fimmu.2018.02709

The Effect of the Sulfonyl Group on the Nucleophilic Displacement of Halogen in α-Halo Sulfones and Related Substances ¹
journal, November 1951

Bordwell, F. G.; Cooper, Glenn D.
Journal of the American Chemical Society, Vol. 73, Issue 11
https://doi.org/10.1021/ja01155a053

Sequential intracellular release of water-soluble cargos from Shell-crosslinked polymersomes
journal, July 2018

Du, Fanfan; Bobbala, Sharan; Yi, Sijia
Journal of Controlled Release, Vol. 282
https://doi.org/10.1016/j.jconrel.2018.03.027

Elastic Behavior of Cross-Linked and Bundled Actin Networks
journal, May 2004

Gardel, M. L.
Science, Vol. 304, Issue 5675
https://doi.org/10.1126/science.1095087

All-Atom Molecular Dynamics Study of Water–Dodecane Interface in the Presence of Octanol
journal, December 2017

Qiao, Baofu; Jiang, Wei
The Journal of Physical Chemistry C, Vol. 122, Issue 1
https://doi.org/10.1021/acs.jpcc.7b10997

Dynamic peptide libraries for the discovery of supramolecular nanomaterials
journal, October 2016

Pappas, Charalampos G.; Shafi, Ramim; Sasselli, Ivan R.
Nature Nanotechnology, Vol. 11, Issue 11
https://doi.org/10.1038/nnano.2016.169

Structure and Dynamics of the TIP3P, SPC, and SPC/E Water Models at 298 K
journal, November 2001

Mark, Pekka; Nilsson, Lennart
The Journal of Physical Chemistry A, Vol. 105, Issue 43
https://doi.org/10.1021/jp003020w

Using DNA to program the self-assembly of colloidal nanoparticles and microparticles
journal, March 2016

Rogers, W. Benjamin; Shih, William M.; Manoharan, Vinothan N.
Nature Reviews Materials, Vol. 1, Issue 3
https://doi.org/10.1038/natrevmats.2016.8

Reversible self-assembly of superstructured networks
journal, October 2018

Freeman, Ronit; Han, Ming; Álvarez, Zaida
Science, Vol. 362, Issue 6416
https://doi.org/10.1126/science.aat6141

Monodisperse cylindrical micelles by crystallization-driven living self-assembly
journal, May 2010

Gilroy, Joe B.; Gädt, Torben; Whittell, George R.
Nature Chemistry, Vol. 2, Issue 7
https://doi.org/10.1038/nchem.664

Liposomes as carriers of hydrophilic small molecule drugs: Strategies to enhance encapsulation and delivery
journal, November 2014

Eloy, Josimar Oliveira; Claro de Souza, Marina; Petrilli, Raquel
Colloids and Surfaces B: Biointerfaces, Vol. 123
https://doi.org/10.1016/j.colsurfb.2014.09.029

Poloxamer 407‐chitosan grafted thermoresponsive hydrogels achieve synchronous and sustained release of antigen and adjuvant from single‐shot vaccines
journal, March 2018

Bobbala, Sharan; Gibson, Blake; Gamble, Allan B.
Immunology & Cell Biology, Vol. 96, Issue 6
https://doi.org/10.1111/imcb.12031

Gadolinium-functionalized nanoparticles for application as magnetic resonance imaging contrast agents via polymerization-induced self-assembly
journal, January 2016

Esser, Lars; Truong, Nghia P.; Karagoz, Bunyamin
Polymer Chemistry, Vol. 7, Issue 47
https://doi.org/10.1039/C6PY01797E

Self-assembly of block copolymers
journal, January 2012

Mai, Yiyong; Eisenberg, Adi
Chemical Society Reviews, Vol. 41, Issue 18
https://doi.org/10.1039/c2cs35115c

Atomic structures of amyloid cross-β spines reveal varied steric zippers
journal, April 2007

Sawaya, Michael R.; Sambashivan, Shilpa; Nelson, Rebecca
Nature, Vol. 447, Issue 7143
https://doi.org/10.1038/nature05695

Immunotheranostic Polymersomes Modularly Assembled from Tetrablock and Diblock Copolymers with Oxidation-Responsive Fluorescence
journal, April 2017

Du, Fanfan; Liu, Yu-Gang; Scott, Evan Alexander
Cellular and Molecular Bioengineering, Vol. 10, Issue 5
https://doi.org/10.1007/s12195-017-0486-7

Tailoring Nanostructure Morphology for Enhanced Targeting of Dendritic Cells in Atherosclerosis
journal, November 2016

Yi, Sijia; Allen, Sean David; Liu, Yu-Gang
ACS Nano, Vol. 10, Issue 12
https://doi.org/10.1021/acsnano.6b06451

Toll-like receptor 8 agonist nanoparticles mimic immunomodulating effects of the live BCG vaccine and enhance neonatal innate and adaptive immune responses
journal, November 2017

Dowling, David J.; Scott, Evan A.; Scheid, Annette
Journal of Allergy and Clinical Immunology, Vol. 140, Issue 5
https://doi.org/10.1016/j.jaci.2016.12.985

Optical Nanoimaging for Block Copolymer Self-Assembly
journal, February 2015

Yan, Jie; Zhao, Ling-Xi; Li, Chong
Journal of the American Chemical Society, Vol. 137, Issue 7
https://doi.org/10.1021/ja512189a

Magnetic torque tweezers: measuring torsional stiffness in DNA and RecA-DNA filaments
journal, October 2010

Lipfert, Jan; Kerssemakers, Jacob W. J.; Jager, Tessa
Nature Methods, Vol. 7, Issue 12
https://doi.org/10.1038/nmeth.1520

Protein self-assembly via supramolecular strategies
journal, January 2016

Bai, Yushi; Luo, Quan; Liu, Junqiu
Chemical Society Reviews, Vol. 45, Issue 10
https://doi.org/10.1039/C6CS00004E

Block Copolymer Micelles in Nanomedicine Applications
journal, June 2018

Cabral, Horacio; Miyata, Kanjiro; Osada, Kensuke
Chemical Reviews, Vol. 118, Issue 14
https://doi.org/10.1021/acs.chemrev.8b00199

Preparing Semiconducting Nanoribbons with Tunable Length and Width via Crystallization-Driven Self-Assembly of a Simple Conjugated Homopolymer
journal, November 2018

Choi, Inho; Yang, Sanghee; Choi, Tae-Lim
Journal of the American Chemical Society, Vol. 140, Issue 49
https://doi.org/10.1021/jacs.8b10406

Hydrogen-Bonding-Driven 3D Supramolecular Assembly of Peptidomimetic Zipper
journal, March 2018

Teng, Peng; Niu, Zheng; She, Fengyu
Journal of the American Chemical Society, Vol. 140, Issue 17
https://doi.org/10.1021/jacs.7b11997

Oxidation-responsive polymeric vesicles
journal, February 2004

Napoli, Alessandro; Valentini, Massimiliano; Tirelli, Nicola
Nature Materials, Vol. 3, Issue 3
https://doi.org/10.1038/nmat1081

Fast Parallel Algorithms for Short-Range Molecular Dynamics
journal, March 1995

Plimpton, Steve
Journal of Computational Physics, Vol. 117, Issue 1
https://doi.org/10.1006/jcph.1995.1039

Water follows polar and nonpolar protein surface domains
journal, September 2019

Qiao, Baofu; Jiménez-Ángeles, Felipe; Nguyen, Trung Dac
Proceedings of the National Academy of Sciences, Vol. 116, Issue 39
https://doi.org/10.1073/pnas.1910225116

Peptide-specific T helper cells identified by MHC class II tetramers differentiate into several subtypes upon immunization with CAF01 adjuvanted H56 tuberculosis vaccine formulation
journal, November 2015

Prota, Gennaro; Christensen, Dennis; Andersen, Peter
Vaccine, Vol. 33, Issue 48
https://doi.org/10.1016/j.vaccine.2015.09.024

The MARTINI Coarse-Grained Force Field: Extension to Proteins
journal, April 2008

Monticelli, Luca; Kandasamy, Senthil K.; Periole, Xavier
Journal of Chemical Theory and Computation, Vol. 4, Issue 5
https://doi.org/10.1021/ct700324x

How Hydrogen Bonds Affect the Growth of Reverse Micelles around Coordinating Metal Ions
journal, March 2014

Qiao, Baofu; Demars, Thomas; Olvera de la Cruz, Monica
The Journal of Physical Chemistry Letters, Vol. 5, Issue 8
https://doi.org/10.1021/jz500495p

Structural DNA Nanotechnology: State of the Art and Future Perspective
journal, July 2014

Zhang, Fei; Nangreave, Jeanette; Liu, Yan
Journal of the American Chemical Society, Vol. 136, Issue 32
https://doi.org/10.1021/ja505101a

Polymersomes scalably fabricated via flash nanoprecipitation are non-toxic in non-human primates and associate with leukocytes in the spleen and kidney following intravenous administration
journal, April 2018

Allen, Sean D.; Liu, Yu-Gang; Bobbala, Sharan
Nano Research, Vol. 11, Issue 10
https://doi.org/10.1007/s12274-018-2069-x

Is There an Optimal Formulation and Delivery Strategy for Subunit Vaccines?
journal, July 2016

Bobbala, Sharan; Hook, Sarah
Pharmaceutical Research, Vol. 33, Issue 9
https://doi.org/10.1007/s11095-016-1979-0

Tunable T cell immunity towards a protein antigen using polymersomes vs. solid-core nanoparticles
journal, June 2013

Stano, Armando; Scott, Evan A.; Dane, Karen Y.
Biomaterials, Vol. 34, Issue 17
https://doi.org/10.1016/j.biomaterials.2013.02.024

Sustained micellar delivery via inducible transitions in nanostructure morphology
journal, February 2018

Karabin, Nicholas B.; Allen, Sean; Kwon, Ha-Kyung
Nature Communications, Vol. 9, Issue 1
https://doi.org/10.1038/s41467-018-03001-9

New Synthetic Methodologies for Amphiphilic Multiblock Copolymers of Ethylene Glycol and Propylene Sulfide
journal, December 2001

Napoli, A.; Tirelli, N.; Kilcher, G.
Macromolecules, Vol. 34, Issue 26
https://doi.org/10.1021/ma0108057

Facile assembly and loading of theranostic polymersomes via multi-impingement flash nanoprecipitation
journal, September 2017

Allen, Sean; Osorio, Omar; Liu, Yu-Gang
Journal of Controlled Release, Vol. 262
https://doi.org/10.1016/j.jconrel.2017.07.026

GROMACS 4: Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation
journal, February 2008

Hess, Berk; Kutzner, Carsten; van der Spoel, David
Journal of Chemical Theory and Computation, Vol. 4, Issue 3
https://doi.org/10.1021/ct700301q

DNA nanotechnology
journal, November 2017

Seeman, Nadrian C.; Sleiman, Hanadi F.
Nature Reviews Materials, Vol. 3, Issue 1
https://doi.org/10.1038/natrevmats.2017.68

Feedback-Induced Temporal Control of “Breathing” Polymersomes To Create Self-Adaptive Nanoreactors
journal, April 2018

Che, Hailong; Cao, Shoupeng; van Hest, Jan C. M.
Journal of the American Chemical Society, Vol. 140, Issue 16
https://doi.org/10.1021/jacs.8b02387

Why are dimethyl sulfoxide and dimethyl sulfone such good solvents?
journal, May 2008

Clark, Timothy; Murray, Jane S.; Lane, Pat
Journal of Molecular Modeling, Vol. 14, Issue 8
https://doi.org/10.1007/s00894-008-0279-y

Getting into Shape: Reflections on a New Generation of Cylindrical Nanostructures’ Self-Assembly Using Polymer Building Blocks
journal, January 2019

Foster, Jeffrey C.; Varlas, Spyridon; Couturaud, Benoit
Journal of the American Chemical Society, Vol. 141, Issue 7
https://doi.org/10.1021/jacs.8b08648

The MARTINI Force Field: Coarse Grained Model for Biomolecular Simulations
journal, July 2007

Marrink, Siewert J.; Risselada, H. Jelger; Yefimov, Serge
The Journal of Physical Chemistry B, Vol. 111, Issue 27
https://doi.org/10.1021/jp071097f

Exposure of the lysine in the gamma chain dodecapeptide of human fibrinogen is not enhanced by adsorption to poly(ethylene terephthalate) as measured by biotinylation and mass spectrometry
journal, December 2011

Ovod, Vitaliy; Scott, Evan A.; Flake, Megan M.
Journal of Biomedical Materials Research Part A, Vol. 100A, Issue 3
https://doi.org/10.1002/jbm.a.33285

Molecular self-assembly and nanochemistry: a chemical strategy for the synthesis of nanostructures
journal, November 1991

Whitesides, G.; Mathias, J.; Seto, C.
Science, Vol. 254, Issue 5036
https://doi.org/10.1126/science.1962191

Folding DNA to create nanoscale shapes and patterns
journal, March 2006

Rothemund, Paul W. K.
Nature, Vol. 440, Issue 7082, p. 297-302
https://doi.org/10.1038/nature04586

“Mirror”-like Protein Dimers Stabilized by Local Heterogeneity at Protein Surfaces
journal, April 2019

Qiao, Baofu; Lopez, Luis; Olvera de la Cruz, Monica
The Journal of Physical Chemistry B, Vol. 123, Issue 18
https://doi.org/10.1021/acs.jpcb.9b01394

Polymeric nanostructured materials for biomedical applications
journal, September 2016

Tang, Zhaohui; He, Chaoliang; Tian, Huayu
Progress in Polymer Science, Vol. 60
https://doi.org/10.1016/j.progpolymsci.2016.05.005

Peptide supramolecular materials for therapeutics
journal, January 2018

Sato, Kohei; Hendricks, Mark P.; Palmer, Liam C.
Chemical Society Reviews, Vol. 47, Issue 20
https://doi.org/10.1039/C7CS00735C

Molecular Origins of Mesoscale Ordering in a Metalloamphiphile Phase
journal, December 2015

Qiao, Baofu; Ferru, Geoffroy; Olvera de la Cruz, Monica
ACS Central Science, Vol. 1, Issue 9
https://doi.org/10.1021/acscentsci.5b00306

Dynamic Ordering and Phase Segregation in Hydrogen-Bonded Polymers
journal, June 2016

Chen, Senbin; Binder, Wolfgang H.
Accounts of Chemical Research, Vol. 49, Issue 7
https://doi.org/10.1021/acs.accounts.6b00174

Therapeutic Vesicular Nanoreactors with Tumor‐Specific Activation and Self‐Destruction for Synergistic Tumor Ablation
journal, October 2017

Li, Junjie; Dirisala, Anjaneyulu; Ge, Zhishen
Angewandte Chemie, Vol. 129, Issue 45
https://doi.org/10.1002/ange.201706964

Particle mesh Ewald: An N ⋅log( N ) method for Ewald sums in large systems
journal, June 1993

Darden, Tom; York, Darrin; Pedersen, Lee
The Journal of Chemical Physics, Vol. 98, Issue 12
https://doi.org/10.1063/1.464397

Extension of the CHARMM general force field to sulfonyl-containing compounds and its utility in biomolecular simulations
journal, July 2012

Yu, Wenbo; He, Xibing; Vanommeslaeghe, Kenno
Journal of Computational Chemistry, Vol. 33, Issue 31
https://doi.org/10.1002/jcc.23067

A Flexible All-Atom Model of Dimethyl Sulfoxide for Molecular Dynamics Simulations
journal, February 2002

Strader, Matthew L.; Feller, Scott E.
The Journal of Physical Chemistry A, Vol. 106, Issue 6
https://doi.org/10.1021/jp013658n

Random heteropolymers preserve protein function in foreign environments
journal, March 2018

Panganiban, Brian; Qiao, Baofu; Jiang, Tao
Science, Vol. 359, Issue 6381
https://doi.org/10.1126/science.aao0335

Synthesis and Solution Properties of Zwitterionic Polymers ^†
journal, November 2002

Lowe, Andrew B.; McCormick, Charles L.
Chemical Reviews, Vol. 102, Issue 11
https://doi.org/10.1021/cr020371t

Supramolecular block copolymers by kinetically controlled co-self-assembly of planar and core-twisted perylene bisimides
journal, May 2015

Görl, Daniel; Zhang, Xin; Stepanenko, Vladimir
Nature Communications, Vol. 6, Issue 1
https://doi.org/10.1038/ncomms8009

Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles
journal, January 2019

Markwalter, Chester E.; Pagels, Robert F.; Wilson, Brian K.
Journal of Visualized Experiments, Issue 143
https://doi.org/10.3791/58757

Self-assembly of random copolymers
journal, January 2014

Li, Longyu; Raghupathi, Kishore; Song, Cunfeng
Chem. Commun., Vol. 50, Issue 88
https://doi.org/10.1039/C4CC03688C

Using the dynamic bond to access macroscopically responsive structurally dynamic polymers
journal, December 2010

Wojtecki, Rudy J.; Meador, Michael A.; Rowan, Stuart J.
Nature Materials, Vol. 10, Issue 1
https://doi.org/10.1038/nmat2891

Combining the MARTINI and Structure-Based Coarse-Grained Approaches for the Molecular Dynamics Studies of Conformational Transitions in Proteins
journal, February 2017

Poma, Adolfo B.; Cieplak, Marek; Theodorakis, Panagiotis E.
Journal of Chemical Theory and Computation, Vol. 13, Issue 3
https://doi.org/10.1021/acs.jctc.6b00986

Mechanical design of DNA nanostructures
journal, January 2015

Castro, Carlos E.; Su, Hai-Jun; Marras, Alexander E.
Nanoscale, Vol. 7, Issue 14
https://doi.org/10.1039/C4NR07153K

Combining an Elastic Network With a Coarse-Grained Molecular Force Field: Structure, Dynamics, and Intermolecular Recognition
journal, August 2009

Periole, Xavier; Cavalli, Marco; Marrink, Siewert-Jan
Journal of Chemical Theory and Computation, Vol. 5, Issue 9
https://doi.org/10.1021/ct9002114

P-LINCS: A Parallel Linear Constraint Solver for Molecular Simulation
journal, December 2007

Hess, Berk
Journal of Chemical Theory and Computation, Vol. 4, Issue 1
https://doi.org/10.1021/ct700200b

An Allosteric Pathway in Copper, Zinc Superoxide Dismutase Unravels the Molecular Mechanism of the G93A Amyotrophic Lateral Sclerosis-Linked Mutation
journal, November 2019

Souza, Paulo C. T.; Thallmair, Sebastian; Marrink, Siewert J.
The Journal of Physical Chemistry Letters, Vol. 10, Issue 24
https://doi.org/10.1021/acs.jpclett.9b02868

Polymersomes
journal, August 2006

Discher, Dennis E.; Ahmed, Fariyal
Annual Review of Biomedical Engineering, Vol. 8, Issue 1
https://doi.org/10.1146/annurev.bioeng.8.061505.095838

Actin-binding proteins sensitively mediate F-actin bundle stiffness
journal, August 2006

Claessens, Mireille M. A. E.; Bathe, Mark; Frey, Erwin
Nature Materials, Vol. 5, Issue 9
https://doi.org/10.1038/nmat1718

Dendritic cell activation and T cell priming with adjuvant- and antigen-loaded oxidation-sensitive polymersomes
journal, September 2012

Scott, Evan A.; Stano, Armando; Gillard, Morgane
Biomaterials, Vol. 33, Issue 26
https://doi.org/10.1016/j.biomaterials.2012.04.060

All-Atom Empirical Potential for Molecular Modeling and Dynamics Studies of Proteins ^†
journal, April 1998

MacKerell, A. D.; Bashford, D.; Bellott, M.
The Journal of Physical Chemistry B, Vol. 102, Issue 18
https://doi.org/10.1021/jp973084f

Water Dynamics from the Surface to the Interior of a Supramolecular Nanostructure
journal, June 2017

Ortony, Julia H.; Qiao, Baofu; Newcomb, Christina J.
Journal of the American Chemical Society, Vol. 139, Issue 26
https://doi.org/10.1021/jacs.7b02969

De novo design of protein homo-oligomers with modular hydrogen-bond network-mediated specificity
journal, May 2016

Boyken, S. E.; Chen, Z.; Groves, B.
Science, Vol. 352, Issue 6286
https://doi.org/10.1126/science.aad8865

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Title: Molecular entrapment via homopolymer self-assembly

Abstract

Citation Formats

Lipid-based nanovesicles for nanomedicine journal, January 2016

Initiation of the adaptive immune response to Mycobacterium tuberculosis depends on antigen production in the local lymph node, not the lungs journal, December 2007

Mass spectrometric mapping of fibrinogen conformations at poly(ethylene terephthalate) interfaces☆ journal, September 2007

Liposome production by microfluidics: potential and limiting factors journal, May 2016

Precision Intracellular Delivery Based on Optofluidic Polymersome Rupture journal, August 2012

Biodegradable STING agonist nanoparticles for enhanced cancer immunotherapy journal, February 2018

Stable Isotope Labeling Tandem Mass Spectrometry (SILT): Integration with Peptide Identification and Extension to Data-Dependent Scans journal, September 2008

Liquid worm-like and proto-micelles: water solubilization in amphiphile–oil solutions journal, January 2018

Structure of the cross-β spine of amyloid-like fibrils journal, June 2005

CHARMM36m: an improved force field for folded and intrinsically disordered proteins journal, November 2016

PEG-SS-PPS: Reduction-Sensitive Disulfide Block Copolymer Vesicles for Intracellular Drug Delivery journal, June 2007

Settle: An analytical version of the SHAKE and RATTLE algorithm for rigid water models journal, October 1992

Supramolecular polymer networks: hydrogels and bulk materials journal, January 2016

A New Initiator System for the Living Thiiranes Ring-Opening Polymerization: A Way toward Star-Shaped Polythiiranes journal, June 1999

Chemisorbed poly(propylene sulphide)-based copolymers resist biomolecular interactions journal, March 2003

A smooth particle mesh Ewald method journal, November 1995

Sustained delivery by a cyclodextrin material-based nanocarrier potentiates antiatherosclerotic activity of rapamycin via selectively inhibiting mTORC1 in mice journal, August 2016

Surface Engineered Polymersomes for Enhanced Modulation of Dendritic Cells During Cardiovascular Immunotherapy journal, August 2019

Biological Photothermal Nanodots Based on Self-Assembly of Peptide–Porphyrin Conjugates for Antitumor Therapy journal, January 2017

Polymersome carriers: From self-assembly to siRNA and protein therapeutics journal, March 2009

Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement journal, March 2017

Dual Carfilzomib and Doxorubicin–Loaded Liposomal Nanoparticles for Synergistic Efficacy in Multiple Myeloma journal, July 2016

Perspective on the Martini model journal, January 2013

Induction of Mycobacterium Tuberculosis Lipid-Specific T Cell Responses by Pulmonary Delivery of Mycolic Acid-Loaded Polymeric Micellar Nanocarriers journal, November 2018

The Effect of the Sulfonyl Group on the Nucleophilic Displacement of Halogen in α-Halo Sulfones and Related Substances 1 journal, November 1951

Sequential intracellular release of water-soluble cargos from Shell-crosslinked polymersomes journal, July 2018

Elastic Behavior of Cross-Linked and Bundled Actin Networks journal, May 2004

All-Atom Molecular Dynamics Study of Water–Dodecane Interface in the Presence of Octanol journal, December 2017

Dynamic peptide libraries for the discovery of supramolecular nanomaterials journal, October 2016

Structure and Dynamics of the TIP3P, SPC, and SPC/E Water Models at 298 K journal, November 2001

Using DNA to program the self-assembly of colloidal nanoparticles and microparticles journal, March 2016

Reversible self-assembly of superstructured networks journal, October 2018

Monodisperse cylindrical micelles by crystallization-driven living self-assembly journal, May 2010

Liposomes as carriers of hydrophilic small molecule drugs: Strategies to enhance encapsulation and delivery journal, November 2014

Poloxamer 407‐chitosan grafted thermoresponsive hydrogels achieve synchronous and sustained release of antigen and adjuvant from single‐shot vaccines journal, March 2018

Gadolinium-functionalized nanoparticles for application as magnetic resonance imaging contrast agents via polymerization-induced self-assembly journal, January 2016

Self-assembly of block copolymers journal, January 2012

Atomic structures of amyloid cross-β spines reveal varied steric zippers journal, April 2007

Immunotheranostic Polymersomes Modularly Assembled from Tetrablock and Diblock Copolymers with Oxidation-Responsive Fluorescence journal, April 2017

Tailoring Nanostructure Morphology for Enhanced Targeting of Dendritic Cells in Atherosclerosis journal, November 2016

Toll-like receptor 8 agonist nanoparticles mimic immunomodulating effects of the live BCG vaccine and enhance neonatal innate and adaptive immune responses journal, November 2017

Optical Nanoimaging for Block Copolymer Self-Assembly journal, February 2015

Magnetic torque tweezers: measuring torsional stiffness in DNA and RecA-DNA filaments journal, October 2010

Protein self-assembly via supramolecular strategies journal, January 2016

Block Copolymer Micelles in Nanomedicine Applications journal, June 2018

Preparing Semiconducting Nanoribbons with Tunable Length and Width via Crystallization-Driven Self-Assembly of a Simple Conjugated Homopolymer journal, November 2018

Hydrogen-Bonding-Driven 3D Supramolecular Assembly of Peptidomimetic Zipper journal, March 2018

Oxidation-responsive polymeric vesicles journal, February 2004

Fast Parallel Algorithms for Short-Range Molecular Dynamics journal, March 1995

Water follows polar and nonpolar protein surface domains journal, September 2019

Peptide-specific T helper cells identified by MHC class II tetramers differentiate into several subtypes upon immunization with CAF01 adjuvanted H56 tuberculosis vaccine formulation journal, November 2015

The MARTINI Coarse-Grained Force Field: Extension to Proteins journal, April 2008

How Hydrogen Bonds Affect the Growth of Reverse Micelles around Coordinating Metal Ions journal, March 2014

Structural DNA Nanotechnology: State of the Art and Future Perspective journal, July 2014

Polymersomes scalably fabricated via flash nanoprecipitation are non-toxic in non-human primates and associate with leukocytes in the spleen and kidney following intravenous administration journal, April 2018

Is There an Optimal Formulation and Delivery Strategy for Subunit Vaccines? journal, July 2016

Tunable T cell immunity towards a protein antigen using polymersomes vs. solid-core nanoparticles journal, June 2013

Sustained micellar delivery via inducible transitions in nanostructure morphology journal, February 2018

New Synthetic Methodologies for Amphiphilic Multiblock Copolymers of Ethylene Glycol and Propylene Sulfide journal, December 2001

Facile assembly and loading of theranostic polymersomes via multi-impingement flash nanoprecipitation journal, September 2017

GROMACS 4: Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation journal, February 2008

DNA nanotechnology journal, November 2017

Feedback-Induced Temporal Control of “Breathing” Polymersomes To Create Self-Adaptive Nanoreactors journal, April 2018

Why are dimethyl sulfoxide and dimethyl sulfone such good solvents? journal, May 2008

Getting into Shape: Reflections on a New Generation of Cylindrical Nanostructures’ Self-Assembly Using Polymer Building Blocks journal, January 2019

The MARTINI Force Field: Coarse Grained Model for Biomolecular Simulations journal, July 2007

Exposure of the lysine in the gamma chain dodecapeptide of human fibrinogen is not enhanced by adsorption to poly(ethylene terephthalate) as measured by biotinylation and mass spectrometry journal, December 2011

Molecular self-assembly and nanochemistry: a chemical strategy for the synthesis of nanostructures journal, November 1991

Folding DNA to create nanoscale shapes and patterns journal, March 2006

“Mirror”-like Protein Dimers Stabilized by Local Heterogeneity at Protein Surfaces journal, April 2019

Polymeric nanostructured materials for biomedical applications journal, September 2016

Peptide supramolecular materials for therapeutics journal, January 2018

Molecular Origins of Mesoscale Ordering in a Metalloamphiphile Phase journal, December 2015

Dynamic Ordering and Phase Segregation in Hydrogen-Bonded Polymers journal, June 2016

Therapeutic Vesicular Nanoreactors with Tumor‐Specific Activation and Self‐Destruction for Synergistic Tumor Ablation journal, October 2017

Particle mesh Ewald: An N ⋅log( N ) method for Ewald sums in large systems journal, June 1993

Extension of the CHARMM general force field to sulfonyl-containing compounds and its utility in biomolecular simulations journal, July 2012

Lipid-based nanovesicles for nanomedicine
journal, January 2016

Initiation of the adaptive immune response to Mycobacterium tuberculosis depends on antigen production in the local lymph node, not the lungs
journal, December 2007

Mass spectrometric mapping of fibrinogen conformations at poly(ethylene terephthalate) interfaces☆
journal, September 2007

Liposome production by microfluidics: potential and limiting factors
journal, May 2016

Precision Intracellular Delivery Based on Optofluidic Polymersome Rupture
journal, August 2012

Biodegradable STING agonist nanoparticles for enhanced cancer immunotherapy
journal, February 2018

Stable Isotope Labeling Tandem Mass Spectrometry (SILT): Integration with Peptide Identification and Extension to Data-Dependent Scans
journal, September 2008

Liquid worm-like and proto-micelles: water solubilization in amphiphile–oil solutions
journal, January 2018

Structure of the cross-β spine of amyloid-like fibrils
journal, June 2005

CHARMM36m: an improved force field for folded and intrinsically disordered proteins
journal, November 2016

PEG-SS-PPS: Reduction-Sensitive Disulfide Block Copolymer Vesicles for Intracellular Drug Delivery
journal, June 2007

Settle: An analytical version of the SHAKE and RATTLE algorithm for rigid water models
journal, October 1992

Supramolecular polymer networks: hydrogels and bulk materials
journal, January 2016

A New Initiator System for the Living Thiiranes Ring-Opening Polymerization: A Way toward Star-Shaped Polythiiranes
journal, June 1999

Chemisorbed poly(propylene sulphide)-based copolymers resist biomolecular interactions
journal, March 2003

A smooth particle mesh Ewald method
journal, November 1995

Sustained delivery by a cyclodextrin material-based nanocarrier potentiates antiatherosclerotic activity of rapamycin via selectively inhibiting mTORC1 in mice
journal, August 2016

Surface Engineered Polymersomes for Enhanced Modulation of Dendritic Cells During Cardiovascular Immunotherapy
journal, August 2019

Biological Photothermal Nanodots Based on Self-Assembly of Peptide–Porphyrin Conjugates for Antitumor Therapy
journal, January 2017

Polymersome carriers: From self-assembly to siRNA and protein therapeutics
journal, March 2009

Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement
journal, March 2017

Dual Carfilzomib and Doxorubicin–Loaded Liposomal Nanoparticles for Synergistic Efficacy in Multiple Myeloma
journal, July 2016

Perspective on the Martini model
journal, January 2013

Induction of Mycobacterium Tuberculosis Lipid-Specific T Cell Responses by Pulmonary Delivery of Mycolic Acid-Loaded Polymeric Micellar Nanocarriers
journal, November 2018

The Effect of the Sulfonyl Group on the Nucleophilic Displacement of Halogen in α-Halo Sulfones and Related Substances ¹
journal, November 1951

Sequential intracellular release of water-soluble cargos from Shell-crosslinked polymersomes
journal, July 2018

Elastic Behavior of Cross-Linked and Bundled Actin Networks
journal, May 2004

All-Atom Molecular Dynamics Study of Water–Dodecane Interface in the Presence of Octanol
journal, December 2017

Dynamic peptide libraries for the discovery of supramolecular nanomaterials
journal, October 2016

Structure and Dynamics of the TIP3P, SPC, and SPC/E Water Models at 298 K
journal, November 2001

Using DNA to program the self-assembly of colloidal nanoparticles and microparticles
journal, March 2016

Reversible self-assembly of superstructured networks
journal, October 2018

Monodisperse cylindrical micelles by crystallization-driven living self-assembly
journal, May 2010

Liposomes as carriers of hydrophilic small molecule drugs: Strategies to enhance encapsulation and delivery
journal, November 2014

Poloxamer 407‐chitosan grafted thermoresponsive hydrogels achieve synchronous and sustained release of antigen and adjuvant from single‐shot vaccines
journal, March 2018

Gadolinium-functionalized nanoparticles for application as magnetic resonance imaging contrast agents via polymerization-induced self-assembly
journal, January 2016

Self-assembly of block copolymers
journal, January 2012

Atomic structures of amyloid cross-β spines reveal varied steric zippers
journal, April 2007

Immunotheranostic Polymersomes Modularly Assembled from Tetrablock and Diblock Copolymers with Oxidation-Responsive Fluorescence
journal, April 2017

Tailoring Nanostructure Morphology for Enhanced Targeting of Dendritic Cells in Atherosclerosis
journal, November 2016

Toll-like receptor 8 agonist nanoparticles mimic immunomodulating effects of the live BCG vaccine and enhance neonatal innate and adaptive immune responses
journal, November 2017

Optical Nanoimaging for Block Copolymer Self-Assembly
journal, February 2015

Magnetic torque tweezers: measuring torsional stiffness in DNA and RecA-DNA filaments
journal, October 2010

Protein self-assembly via supramolecular strategies
journal, January 2016

Block Copolymer Micelles in Nanomedicine Applications
journal, June 2018

Preparing Semiconducting Nanoribbons with Tunable Length and Width via Crystallization-Driven Self-Assembly of a Simple Conjugated Homopolymer
journal, November 2018

Hydrogen-Bonding-Driven 3D Supramolecular Assembly of Peptidomimetic Zipper
journal, March 2018

Oxidation-responsive polymeric vesicles
journal, February 2004

Fast Parallel Algorithms for Short-Range Molecular Dynamics
journal, March 1995

Water follows polar and nonpolar protein surface domains
journal, September 2019

Peptide-specific T helper cells identified by MHC class II tetramers differentiate into several subtypes upon immunization with CAF01 adjuvanted H56 tuberculosis vaccine formulation
journal, November 2015

The MARTINI Coarse-Grained Force Field: Extension to Proteins
journal, April 2008

How Hydrogen Bonds Affect the Growth of Reverse Micelles around Coordinating Metal Ions
journal, March 2014

Structural DNA Nanotechnology: State of the Art and Future Perspective
journal, July 2014

Polymersomes scalably fabricated via flash nanoprecipitation are non-toxic in non-human primates and associate with leukocytes in the spleen and kidney following intravenous administration
journal, April 2018

Is There an Optimal Formulation and Delivery Strategy for Subunit Vaccines?
journal, July 2016

Tunable T cell immunity towards a protein antigen using polymersomes vs. solid-core nanoparticles
journal, June 2013

Sustained micellar delivery via inducible transitions in nanostructure morphology
journal, February 2018

New Synthetic Methodologies for Amphiphilic Multiblock Copolymers of Ethylene Glycol and Propylene Sulfide
journal, December 2001

Facile assembly and loading of theranostic polymersomes via multi-impingement flash nanoprecipitation
journal, September 2017

GROMACS 4: Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation
journal, February 2008

DNA nanotechnology
journal, November 2017

Feedback-Induced Temporal Control of “Breathing” Polymersomes To Create Self-Adaptive Nanoreactors
journal, April 2018

Why are dimethyl sulfoxide and dimethyl sulfone such good solvents?
journal, May 2008

Getting into Shape: Reflections on a New Generation of Cylindrical Nanostructures’ Self-Assembly Using Polymer Building Blocks
journal, January 2019

The MARTINI Force Field: Coarse Grained Model for Biomolecular Simulations
journal, July 2007

Exposure of the lysine in the gamma chain dodecapeptide of human fibrinogen is not enhanced by adsorption to poly(ethylene terephthalate) as measured by biotinylation and mass spectrometry
journal, December 2011

Molecular self-assembly and nanochemistry: a chemical strategy for the synthesis of nanostructures
journal, November 1991

Folding DNA to create nanoscale shapes and patterns
journal, March 2006

“Mirror”-like Protein Dimers Stabilized by Local Heterogeneity at Protein Surfaces
journal, April 2019

Polymeric nanostructured materials for biomedical applications
journal, September 2016

Peptide supramolecular materials for therapeutics
journal, January 2018

Molecular Origins of Mesoscale Ordering in a Metalloamphiphile Phase
journal, December 2015

Dynamic Ordering and Phase Segregation in Hydrogen-Bonded Polymers
journal, June 2016

Therapeutic Vesicular Nanoreactors with Tumor‐Specific Activation and Self‐Destruction for Synergistic Tumor Ablation
journal, October 2017

Particle mesh Ewald: An N ⋅log( N ) method for Ewald sums in large systems
journal, June 1993

Extension of the CHARMM general force field to sulfonyl-containing compounds and its utility in biomolecular simulations
journal, July 2012

A Flexible All-Atom Model of Dimethyl Sulfoxide for Molecular Dynamics Simulations
journal, February 2002

Random heteropolymers preserve protein function in foreign environments
journal, March 2018

Synthesis and Solution Properties of Zwitterionic Polymers ^†
journal, November 2002