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Title: Synthesis of N-formyl-3,4-di-t-butoxycarbonyloxy-6(trimethylstannyl)-L-phenylalanine ethyl ester and its regioselective radiofluorodestannylation to 6-[{sup 18}F]fluoro-1-dopa

A process is revealed for forming a 6-fluoro derivative of compounds in the L-Dopa family comprising the steps of protecting the groups attached to the benzene ring in the compound followed by serially reacting the protected compound with (a) iodine and silver trifluoroacetic acid; (b) Bb{sub 3}; (c) dit-butyldicarbonate; (d) hexamethyltin; (e) a fluoro compound; (f) hydrobromic acid; and (g) raising the pH to {<=}7. 1 fig.
Inventors:
; ; ; ;
Issue Date:
OSTI Identifier:
224981
Assignee:
Univ. of California, Oakland, CA (United States) PTO; SCA: 550601; PA: INS-96:011392; EDB-96:082077; SN: 96001577517
Patent Number(s):
US 5,510,522/A/
Application Number:
PAN: 8-393,428; CNN: Grant PO1-NS-15654;Grant RO1-MH-37916
Contract Number:
FC03-87ER60615
Resource Relation:
Other Information: PBD: 23 Apr 1996
Research Org:
University of California
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; RADIOPHARMACEUTICALS; CHEMICAL PREPARATION; FLUORINE 18; TRACER TECHNIQUES; NUCLEAR MEDICINE

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