skip to main content
DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Synthesis of N-formyl-3,4-di-t-butoxycarbonyloxy-6(trimethylstannyl)-L-phenylalanine ethyl ester and its regioselective radiofluorodestannylation to 6-[{sup 18}F]fluoro-1-dopa

Abstract

A process is revealed for forming a 6-fluoro derivative of compounds in the L-Dopa family comprising the steps of protecting the groups attached to the benzene ring in the compound followed by serially reacting the protected compound with (a) iodine and silver trifluoroacetic acid; (b) Bb{sub 3}; (c) dit-butyldicarbonate; (d) hexamethyltin; (e) a fluoro compound; (f) hydrobromic acid; and (g) raising the pH to {<=}7. 1 fig.

Inventors:
; ; ; ;
Issue Date:
Research Org.:
University of California
OSTI Identifier:
224981
Patent Number(s):
5,510,522
Application Number:
PAN: 8-393,428; CNN: Grant PO1-NS-15654;Grant RO1-MH-37916
Assignee:
Univ. of California, Oakland, CA (United States)
DOE Contract Number:  
FC03-87ER60615
Resource Type:
Patent
Resource Relation:
Other Information: PBD: 23 Apr 1996
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; RADIOPHARMACEUTICALS; CHEMICAL PREPARATION; FLUORINE 18; TRACER TECHNIQUES; NUCLEAR MEDICINE

Citation Formats

Satyamurthy, N, Barrio, J R, Bishop, A J, Namavari, M, and Bida, G T. Synthesis of N-formyl-3,4-di-t-butoxycarbonyloxy-6(trimethylstannyl)-L-phenylalanine ethyl ester and its regioselective radiofluorodestannylation to 6-[{sup 18}F]fluoro-1-dopa. United States: N. p., 1996. Web.
Satyamurthy, N, Barrio, J R, Bishop, A J, Namavari, M, & Bida, G T. Synthesis of N-formyl-3,4-di-t-butoxycarbonyloxy-6(trimethylstannyl)-L-phenylalanine ethyl ester and its regioselective radiofluorodestannylation to 6-[{sup 18}F]fluoro-1-dopa. United States.
Satyamurthy, N, Barrio, J R, Bishop, A J, Namavari, M, and Bida, G T. Tue . "Synthesis of N-formyl-3,4-di-t-butoxycarbonyloxy-6(trimethylstannyl)-L-phenylalanine ethyl ester and its regioselective radiofluorodestannylation to 6-[{sup 18}F]fluoro-1-dopa". United States.
@article{osti_224981,
title = {Synthesis of N-formyl-3,4-di-t-butoxycarbonyloxy-6(trimethylstannyl)-L-phenylalanine ethyl ester and its regioselective radiofluorodestannylation to 6-[{sup 18}F]fluoro-1-dopa},
author = {Satyamurthy, N and Barrio, J R and Bishop, A J and Namavari, M and Bida, G T},
abstractNote = {A process is revealed for forming a 6-fluoro derivative of compounds in the L-Dopa family comprising the steps of protecting the groups attached to the benzene ring in the compound followed by serially reacting the protected compound with (a) iodine and silver trifluoroacetic acid; (b) Bb{sub 3}; (c) dit-butyldicarbonate; (d) hexamethyltin; (e) a fluoro compound; (f) hydrobromic acid; and (g) raising the pH to {<=}7. 1 fig.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1996},
month = {4}
}