Producing 3-hydroxycarboxylic acid and ketone using polyketide synthases

Yuzawa, Satoshi; Katz, Leonard; Keasling, Jay D.

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Title: Producing 3-hydroxycarboxylic acid and ketone using polyketide synthases

Abstract

The present invention provides for a polyketide synthase (PKS) capable of synthesizing a 3-hydroxycarboxylic acid or ketone. The present invention also provides for a host cell comprising the PKS and when cultured produces the 3-hydroxycarboxylic acid or ketone.

Inventors:: Yuzawa, Satoshi; Katz, Leonard; Keasling, Jay D.

Issue Date:: 2023-09-05

Research Org.:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 2222274

Patent Number(s):: 11746336

Application Number:: 16/256,931

Assignee:: The Regents of the University of California (Oakland, CA)

DOE Contract Number:: AC02-05CH11231

Resource Type:: Patent

Resource Relation:: Patent File Date: 01/24/2019

Country of Publication:: United States

Language:: English

Citation Formats


                    Yuzawa, Satoshi, Katz, Leonard, and Keasling, Jay D. Producing 3-hydroxycarboxylic acid and ketone using polyketide synthases.  United States: N. p., 2023. 
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                    Yuzawa, Satoshi, Katz, Leonard, & Keasling, Jay D. Producing 3-hydroxycarboxylic acid and ketone using polyketide synthases.  United States.

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                    Yuzawa, Satoshi, Katz, Leonard, and Keasling, Jay D. Tue .  
        "Producing 3-hydroxycarboxylic acid and ketone using polyketide synthases".  United States.  https://www.osti.gov/servlets/purl/2222274.

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@article{osti_2222274,

  title        = {Producing 3-hydroxycarboxylic acid and ketone using polyketide synthases},

  author       = {Yuzawa, Satoshi and Katz, Leonard and Keasling, Jay D.},

  abstractNote = {The present invention provides for a polyketide synthase (PKS) capable of synthesizing a 3-hydroxycarboxylic acid or ketone. The present invention also provides for a host cell comprising the PKS and when cultured produces the 3-hydroxycarboxylic acid or ketone.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2023},

  month        = {9}

}

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Works referenced in this record:

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Similar Records

Title: Producing 3-hydroxycarboxylic acid and ketone using polyketide synthases

Abstract

Citation Formats

Recombinant methods and materials for producing epothilones C and D patent, October 2001

Biosynthetic Gene Cluster for the Polyenoyltetramic Acid -Lipomycin journal, May 2006

Engineering the acyltransferase substrate specificity of assembly line polyketide synthases journal, August 2013

Recombinant production of novel polyketides patent, September 1997

Absolute metabolite concentrations and implied enzyme active site occupancy in Escherichia coli journal, June 2009

Biosynthesis of the avermectins by Streptomyces avermitilis. Incorporation of labeled precursors. journal, January 1986

Biosynthetic origin of the carbon skeleton and oxygen atoms of the avermectins journal, June 1983

Identification of a Phosphopantetheinyl Transferase for Erythromycin Biosynthesis in Saccharopolyspora erythraea journal, December 2003

Producing dicarboxylic acids using polyketide synthases patent, October 2013

Producing biofuels using polyketide synthases patent, April 2013

Engineered biosynthesis of a complete macrolactone in a heterologous host journal, July 1994

Biosynthesis of the Angiogenesis Inhibitor Borrelidin by Streptomyces parvulus Tü4055Cluster Analysis and Assignment of Functions journal, January 2004

A Model of Structure and Catalysis for Ketoreductase Domains in Modular Polyketide Synthases journal, January 2003

Mechanistic Analysis of Acyl Transferase Domain Exchange in Polyketide Synthase Modules journal, May 2003

Novel avermectins produced by mutational biosynthesis. journal, January 1991

Biosynthesis of polyketide synthase substrates patent-application, April 2002

Recombinant production of novel polyketides patent, November 1998

Metabolic engineering of Escherichia coli for improved 6-deoxyerythronolide B production journal, August 2003

Method for producing hybrid polyketide synthases patent, October 2010

Gain-of-Function Mutagenesis of a Modular Polyketide Synthase journal, May 1997

Quantitative Analysis of Loading and Extender Acyltransferases of Modular Polyketide Synthases † journal, January 2003

Production of polyketides in plants patent, July 2001

The effects of biotin deficiency on organic acid metabolism: Increase in propionyl coenzyme A-related organic acids in biotin-deficient rats journal, November 1993

Broad Substrate Specificity of the Loading Didomain of the Lipomycin Polyketide Synthase journal, May 2013

Structural and Functional Characterization of Three Polyketide Synthase Gene Clusters in Bacillus amyloliquefaciens FZB 42 journal, May 2006

Origin of Starter Units for Erythromycin Biosynthesis journal, July 1998

Producing biofuels using polyketide synthases patent-application, January 2011

Branched-chain fatty acid requirement for avermectin production by a mutant of Streptomyces avermitilis lacking branched-chain 2-oxo acid dehydrogenase activity. journal, January 1991

Protocols for the preparation of each of the four possible stereoisomeric .alpha.-alkyl-.beta.-hydroxy carboxylic acids from a single chiral aldol reagent journal, March 1991

Spontaneous Priming of a Downstream Module in 6-Deoxyerythronolide B Synthase Leads to Polyketide Biosynthesis journal, March 1998

Producing dicarboxylic acids using polyketide synthases patent, May 2015

PKS and NRPS release mechanisms journal, January 2010

A new enzyme superfamily — the phosphopantetheinyl transferases journal, January 1996

Biosynthesis of Complex Polyketides in a Metabolically Engineered Strain of E. coli journal, March 2001

Erythromycin Biosynthesis: Kinetic Studies on a Fully Active Modular Polyketide Synthase Using Natural and Unnatural Substrates † journal, January 1996

Producing alpha-olefins using polyketide synthases patent-application, October 2013

Combinatorial biosynthesis of reduced polyketides journal, December 2005

Alteration of the Substrate Specificity of a Modular Polyketide Synthase Acyltransferase Domain through Site-Specific Mutations † journal, December 2001

Evidence for a double-helical structure for modular polyketide synthases journal, February 1996

Recombinant combinatorial genetic library for the production of novel polyketides patent, January 1998

Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: Versatility from a unique substrate channel journal, December 2001

Combinatorial biosynthesis for new drug discovery journal, June 1998

Hybrid polyketide synthases patent-application, October 2013

Recombinant production of novel polyketides patent, December 1998

Producing a trimethylpentanoic acid using hybrid polyketide synthases patent, October 2014

Engineering of a minimal modular polyketide synthase, and targeted alteration of the stereospecificity of polyketide chain extension journal, August 1998

Construction of a Part of a 3-Hydroxypropionate Cycle for Heterologous Polyketide Biosynthesis in Escherichia coli journal, November 2012

Biosynthesis of polyketide synthase substrates patent-application, December 2002

Genetic manipulation of antibioticproducing journal, February 1998

Gain of Function Mutagenesis of the Erythromycin Polyketide Synthase. 2. Engineered Biosynthesis of an Eight-Membered Ring Tetraketide Lactone journal, November 1997

Recombinant methods and materials for producing epothilones C and D
patent, October 2001

Biosynthetic Gene Cluster for the Polyenoyltetramic Acid -Lipomycin
journal, May 2006

Engineering the acyltransferase substrate specificity of assembly line polyketide synthases
journal, August 2013

Recombinant production of novel polyketides
patent, September 1997

Absolute metabolite concentrations and implied enzyme active site occupancy in Escherichia coli
journal, June 2009

Biosynthesis of the avermectins by Streptomyces avermitilis. Incorporation of labeled precursors.
journal, January 1986

Biosynthetic origin of the carbon skeleton and oxygen atoms of the avermectins
journal, June 1983

Identification of a Phosphopantetheinyl Transferase for Erythromycin Biosynthesis in Saccharopolyspora erythraea
journal, December 2003

Producing dicarboxylic acids using polyketide synthases
patent, October 2013

Producing biofuels using polyketide synthases
patent, April 2013

Engineered biosynthesis of a complete macrolactone in a heterologous host
journal, July 1994

Biosynthesis of the Angiogenesis Inhibitor Borrelidin by Streptomyces parvulus Tü4055Cluster Analysis and Assignment of Functions
journal, January 2004

A Model of Structure and Catalysis for Ketoreductase Domains in Modular Polyketide Synthases
journal, January 2003

Mechanistic Analysis of Acyl Transferase Domain Exchange in Polyketide Synthase Modules
journal, May 2003

Novel avermectins produced by mutational biosynthesis.
journal, January 1991

Biosynthesis of polyketide synthase substrates
patent-application, April 2002

Recombinant production of novel polyketides
patent, November 1998

Metabolic engineering of Escherichia coli for improved 6-deoxyerythronolide B production
journal, August 2003

Method for producing hybrid polyketide synthases
patent, October 2010

Gain-of-Function Mutagenesis of a Modular Polyketide Synthase
journal, May 1997

Quantitative Analysis of Loading and Extender Acyltransferases of Modular Polyketide Synthases ^†
journal, January 2003

Production of polyketides in plants
patent, July 2001

The effects of biotin deficiency on organic acid metabolism: Increase in propionyl coenzyme A-related organic acids in biotin-deficient rats
journal, November 1993

Broad Substrate Specificity of the Loading Didomain of the Lipomycin Polyketide Synthase
journal, May 2013

Structural and Functional Characterization of Three Polyketide Synthase Gene Clusters in Bacillus amyloliquefaciens FZB 42
journal, May 2006

Origin of Starter Units for Erythromycin Biosynthesis
journal, July 1998

Producing biofuels using polyketide synthases
patent-application, January 2011

Branched-chain fatty acid requirement for avermectin production by a mutant of Streptomyces avermitilis lacking branched-chain 2-oxo acid dehydrogenase activity.
journal, January 1991

Protocols for the preparation of each of the four possible stereoisomeric .alpha.-alkyl-.beta.-hydroxy carboxylic acids from a single chiral aldol reagent
journal, March 1991

Spontaneous Priming of a Downstream Module in 6-Deoxyerythronolide B Synthase Leads to Polyketide Biosynthesis
journal, March 1998

Producing dicarboxylic acids using polyketide synthases
patent, May 2015

PKS and NRPS release mechanisms
journal, January 2010

A new enzyme superfamily — the phosphopantetheinyl transferases
journal, January 1996

Biosynthesis of Complex Polyketides in a Metabolically Engineered Strain of E. coli
journal, March 2001

Erythromycin Biosynthesis: Kinetic Studies on a Fully Active Modular Polyketide Synthase Using Natural and Unnatural Substrates ^†
journal, January 1996

Producing alpha-olefins using polyketide synthases
patent-application, October 2013

Combinatorial biosynthesis of reduced polyketides
journal, December 2005

Alteration of the Substrate Specificity of a Modular Polyketide Synthase Acyltransferase Domain through Site-Specific Mutations ^†
journal, December 2001

Evidence for a double-helical structure for modular polyketide synthases
journal, February 1996

Recombinant combinatorial genetic library for the production of novel polyketides
patent, January 1998

Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: Versatility from a unique substrate channel
journal, December 2001

Combinatorial biosynthesis for new drug discovery
journal, June 1998

Hybrid polyketide synthases
patent-application, October 2013

Recombinant production of novel polyketides
patent, December 1998

Producing a trimethylpentanoic acid using hybrid polyketide synthases
patent, October 2014

Engineering of a minimal modular polyketide synthase, and targeted alteration of the stereospecificity of polyketide chain extension
journal, August 1998

Construction of a Part of a 3-Hydroxypropionate Cycle for Heterologous Polyketide Biosynthesis in Escherichia coli
journal, November 2012

Biosynthesis of polyketide synthase substrates
patent-application, December 2002

Genetic manipulation of antibioticproducing
journal, February 1998

Gain of Function Mutagenesis of the Erythromycin Polyketide Synthase. 2. Engineered Biosynthesis of an Eight-Membered Ring Tetraketide Lactone
journal, November 1997