Massively parallel, multiple-organ perfusion control system

Reiserer, Ronald S.; Gerken, Gregory B.; Schaffer, David K.; Wikswo, John P.

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Title: Massively parallel, multiple-organ perfusion control system

Abstract

A fluidic cartridge comprises a fluidic disk having a plurality of alignment openings; a fluidic chip comprising a body, one or more channels formed in the body in fluidic communications with input ports and output ports for transferring one or more fluids between the input ports and the output ports, and a plurality of protrusions formed on the body and received in the alignment openings of the fluidic disk for aligning the fluidic chip to the fluidic disk; an actuator operably engaging with the one or more channels for selectively and individually transferring the one or more fluids through the one or more channels from at least one of the input ports to at least one of the output ports at desired flow rates; and a tube member defining a cylindrical housing for accommodating the fluidic disk, the fluidic chip and the actuator therein.

Inventors:: Reiserer, Ronald S.; Gerken, Gregory B.; Schaffer, David K.; Wikswo, John P.

Issue Date:: 2023-09-05

Research Org.:: Vanderbilt Univ., Nashville, TN (United States)

Sponsoring Org.:: USDOE; National Institutes of Health (NIH); National Aeronautics and Space Administration (NASA)

OSTI Identifier:: 2222273

Patent Number(s):: 11746317

Application Number:: 17/984,151

Assignee:: Vanderbilt University (Nashville, TN)

DOE Contract Number:: 2117782; 80NSSC20K0108; CBET-1706155; HHSN44C; U01TR002383; UH3TR002097

Resource Type:: Patent

Resource Relation:: Patent File Date: 11/09/2022

Country of Publication:: United States

Language:: English

Citation Formats


                    Reiserer, Ronald S., Gerken, Gregory B., Schaffer, David K., and Wikswo, John P. Massively parallel, multiple-organ perfusion control system.  United States: N. p., 2023. 
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                    Reiserer, Ronald S., Gerken, Gregory B., Schaffer, David K., & Wikswo, John P. Massively parallel, multiple-organ perfusion control system.  United States.

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                    Reiserer, Ronald S., Gerken, Gregory B., Schaffer, David K., and Wikswo, John P. Tue .  
        "Massively parallel, multiple-organ perfusion control system".  United States.  https://www.osti.gov/servlets/purl/2222273.

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@article{osti_2222273,

  title        = {Massively parallel, multiple-organ perfusion control system},

  author       = {Reiserer, Ronald S. and Gerken, Gregory B. and Schaffer, David K. and Wikswo, John P.},

  abstractNote = {A fluidic cartridge comprises a fluidic disk having a plurality of alignment openings; a fluidic chip comprising a body, one or more channels formed in the body in fluidic communications with input ports and output ports for transferring one or more fluids between the input ports and the output ports, and a plurality of protrusions formed on the body and received in the alignment openings of the fluidic disk for aligning the fluidic chip to the fluidic disk; an actuator operably engaging with the one or more channels for selectively and individually transferring the one or more fluids through the one or more channels from at least one of the input ports to at least one of the output ports at desired flow rates; and a tube member defining a cylindrical housing for accommodating the fluidic disk, the fluidic chip and the actuator therein.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2023},

  month        = {9}

}

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Patent Lewis, Jennifer A.; Skylar-Scott, Mark A.; Mueller, Jochen

In one aspect, the present disclosure provides a nozzle for a 3D printing system. The nozzle may include a flowpath with a material inlet and a material outlet. The nozzle may further include a valve in fluid communication with the flowpath between the material inlet and the material outlet, where the valve includes a closed state and an open state, where in the closed state the valve obstructs the flowpath between the material inlet and the material outlet, and where in the open state the material inlet is in fluid communication with the material outlet. The nozzle may further includemore » « less
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Title: Massively parallel, multiple-organ perfusion control system

Abstract

Citation Formats

Raman spectroscopy as a method to replace off‐line pH during mammalian cell culture processes journal, November 2019

Multianalyte microphysiometry as a tool in metabolomics and systems biology journal, February 2006

Functional genomic hypothesis generation and experimentation by a robot scientist journal, January 2004

SPE-IMS-MS: An automated platform for sub-sixty second surveillance of endogenous metabolites and xenobiotics in biofluids journal, December 2016

An Integrated, High-Throughput Strategy for Multiomic Systems Level Analysis journal, August 2018

Ultrasonic particle-concentration for sheathless focusing of particles for analysis in a flow cytometer journal, January 2006

Advanced Multidimensional Separations in Mass Spectrometry: Navigating the Big Data Deluge journal, June 2016

The future of industrial bioprocessing: Batch or continuous?: The Future of Industrial Bioprocessing journal, February 2015

How Do Control-Based Approaches Enter into Biology? journal, August 2011

Continuous integrated manufacturing of therapeutic proteins journal, October 2018

Surface-enhanced Raman spectroscopy and microfluidic platforms: challenges, solutions and potential applications journal, January 2017

Method and structure of preventing water from leakage for the pressurized pump of diaphragm type patent, February 2011

Recreating blood-brain barrier physiology and structure on chip: A novel neurovascular microfluidic bioreactor journal, September 2015

Cartridge systems, capacitive pumps and multi-throw valves and pump-valve systems and applications of same patent, October 2022

Study of a recombinant CHO cell line producing a monoclonal antibody by ATF or TFF external filter perfusion in a WAVE Bioreactor™ journal, November 2011

Metabolic consequences of inflammatory disruption of the blood-brain barrier in an organ-on-chip model of the human neurovascular unit journal, December 2016

Fitting tissue chips and microphysiological systems into the grand scheme of medicine, biology, pharmacology, and toxicology journal, June 2017

System and method for microdialysis imaging and regional fluidic delivery and control and applications of same patent, January 2020

Circadian hormone control in a human-on-a-chip: In vitro biology’s ignored component? journal, October 2017

Normally closed microvalve and applications of the same patent, April 2017

Peristaltic micropump and related systems and methods patent, September 2020

Interconnections of multiple perfused engineered tissue constructs and microbioreactors, multi-microformulators and applications of the same patent, March 2020

The Use of Chemostats in Microbial Systems Biology journal, October 2013

Systems-level view of cocaine addiction: The interconnection of the immune and nervous systems journal, June 2014

Broadscale resolving power performance of a high precision uniform field ion mobility-mass spectrometer journal, January 2015

Thermoplastic microfluidic bioreactors with integrated electrodes to study tumor treating fields on yeast cells journal, May 2020

Cartridge systems, capacitive pumps and multi-throw valves and pump-valve systems and applications of same patent, October 2021

Monolithic Microfabricated Valves and Pumps by Multilayer Soft Lithography journal, April 2000

Integrated organ-on-chip systems and applications of the same patent, September 2018

In situ Raman spectroscopy for simultaneous monitoring of multiple process parameters in mammalian cell culture bioreactors journal, July 2012

The microfluidic multitrap nanophysiometer for hematologic cancer cell characterization reveals temporal sensitivity of the calcein-AM efflux assay journal, May 2014

Characterization and comparison of ATF and TFF in stirred bioreactors for continuous mammalian cell culture processes journal, June 2016

Microfluidic Large-Scale Integration journal, September 2002

Vacuum membrane pump and a head portion for a vacuum membrane pump patent, March 1999

High-throughput biological screening patent, April 2015

Shear contributions to cell culture performance and product recovery in ATF and TFF perfusion systems journal, March 2017

Raman spectroscopy compatible PDMS droplet microfluidic culture and analysis platform towards on-chip lipidomics journal, January 2017

Real time monitoring of multiple parameters in mammalian cell culture bioreactors using an in-line Raman spectroscopy probe journal, December 2010

Integrated organ-on-chip systems and applications of the same patent, October 2019

Microfluidic systems for extracting nucleic acids for DNA and RNA analysis journal, February 2007

Multichamber multipotentiostat system for cellular microphysiometry journal, December 2014

Organ on chip integration and applications of the same patent, January 2018

Microfluidic Cell Retention Device for Perfusion of Mammalian Suspension Culture journal, July 2017

Air pump with improved air intake control structure patent, October 2010

Raman Spectroscopy Detects Biochemical Changes Due to Proliferation in Mammalian Cell Cultures journal, June 2005

Variation in diffusion of gases through PDMS due to plasma surface treatment and storage conditions journal, September 2013

Description of the Chemostat journal, December 1950

Cheaper faster drug development validated by the repositioning of drugs against neglected tropical diseases journal, March 2015

Quantitative monitoring of yeast fermentation using Raman spectroscopy journal, July 2014

Alternating flow filtration as an alternative to internal spin filter based perfusion process: Impact on productivity and product quality journal, May 2017

Advances in blood–brain barrier modeling in microphysiological systems highlight critical differences in opioid transport due to cortisol exposure journal, June 2020

Membrane-less microfiltration using inertial microfluidics journal, July 2015

Valve with flexible sheet member patent, August 1989

Real-Time Cellular Exometabolome Analysis with a Microfluidic-Mass Spectrometry Platform journal, February 2015

The Robot Scientist Adam journal, August 2009

A Dual-Column Solid Phase Extraction Strategy for Online Collection and Preparation of Continuously Flowing Effluent Streams for Mass Spectrometry journal, September 2012

Slanted spiral microfluidics for the ultra-fast, label-free isolation of circulating tumor cells journal, January 2014

Integrated human organ-on-chip microphysiological systems patent, August 2017

Super-enhanced particle focusing in a novel microchannel geometry using inertial microfluidics journal, April 2017

Device and methods for detecting the response of a plurality of cells to at least one analyte of interest patent, May 2010

Real-Time Monitoring of Cellular Bioenergetics with a Multianalyte Screen-Printed Electrode journal, July 2015

Experiments with the Chemostat on Spontaneous Mutations of Bacteria journal, December 1950

The Automation of Science journal, April 2009

Closed-loop cycles of experiment design, execution, and learning accelerate systems biology model development in yeast journal, August 2019

Modeling the measurements of cellular fluxes in microbioreactor devices using thin enzyme electrodes journal, October 2010

Integrating advanced functionality in a microfabricated high-throughput fluorescent-activated cell sorter journal, January 2003

Interconnections of multiple perfused engineered tissue constructs and microbioreactors, multi-microformulators and applications of the same patent, July 2018

Towards monitoring real-time cellular response using an integrated microfluidics-matrix assisted laser desorption ionisation/nanoelectrospray ionisation-ion mobility-mass spectrometry platform journal, November 2010

Metabolic Discrimination of Select List Agents by Monitoring Cellular Responses in a Multianalyte Microphysiometer journal, March 2009

A bistable, multiport valve enables microformulators creating microclinical analyzers that reveal aberrant glutamate metabolism in astrocytes derived from a tuberous sclerosis patient journal, August 2021

Perfusion mammalian cell culture for recombinant protein manufacturing – A critical review journal, July 2018

Conformational Ordering of Biomolecules in the Gas Phase: Nitrogen Collision Cross Sections Measured on a Prototype High Resolution Drift Tube Ion Mobility-Mass Spectrometer journal, February 2014

Continuous culture - making a comeback? journal, October 2005

Analysis of chemometric models applied to Raman spectroscopy for monitoring key metabolites of cell culture journal, February 2020

An Integrated Raman Spectroscopy and Mass Spectrometry Platform to Study Single-Cell Drug Uptake, Metabolism, and Effects journal, January 2020

Apparatus and methods for monitoring the status of a metabolically active cell patent, April 2010

Peristaltic micropump and related systems and methods patent, November 2019

Raman spectroscopy as a method to replace off‐line pH during mammalian cell culture processes
journal, November 2019

Multianalyte microphysiometry as a tool in metabolomics and systems biology
journal, February 2006

Functional genomic hypothesis generation and experimentation by a robot scientist
journal, January 2004

SPE-IMS-MS: An automated platform for sub-sixty second surveillance of endogenous metabolites and xenobiotics in biofluids
journal, December 2016

An Integrated, High-Throughput Strategy for Multiomic Systems Level Analysis
journal, August 2018

Ultrasonic particle-concentration for sheathless focusing of particles for analysis in a flow cytometer
journal, January 2006

Advanced Multidimensional Separations in Mass Spectrometry: Navigating the Big Data Deluge
journal, June 2016

The future of industrial bioprocessing: Batch or continuous?: The Future of Industrial Bioprocessing
journal, February 2015

How Do Control-Based Approaches Enter into Biology?
journal, August 2011

Continuous integrated manufacturing of therapeutic proteins
journal, October 2018

Surface-enhanced Raman spectroscopy and microfluidic platforms: challenges, solutions and potential applications
journal, January 2017

Method and structure of preventing water from leakage for the pressurized pump of diaphragm type
patent, February 2011

Recreating blood-brain barrier physiology and structure on chip: A novel neurovascular microfluidic bioreactor
journal, September 2015

Cartridge systems, capacitive pumps and multi-throw valves and pump-valve systems and applications of same
patent, October 2022

Study of a recombinant CHO cell line producing a monoclonal antibody by ATF or TFF external filter perfusion in a WAVE Bioreactor™
journal, November 2011

Metabolic consequences of inflammatory disruption of the blood-brain barrier in an organ-on-chip model of the human neurovascular unit
journal, December 2016

Fitting tissue chips and microphysiological systems into the grand scheme of medicine, biology, pharmacology, and toxicology
journal, June 2017

System and method for microdialysis imaging and regional fluidic delivery and control and applications of same
patent, January 2020

Circadian hormone control in a human-on-a-chip: In vitro biology’s ignored component?
journal, October 2017

Normally closed microvalve and applications of the same
patent, April 2017

Peristaltic micropump and related systems and methods
patent, September 2020

Interconnections of multiple perfused engineered tissue constructs and microbioreactors, multi-microformulators and applications of the same
patent, March 2020

The Use of Chemostats in Microbial Systems Biology
journal, October 2013

Systems-level view of cocaine addiction: The interconnection of the immune and nervous systems
journal, June 2014

Broadscale resolving power performance of a high precision uniform field ion mobility-mass spectrometer
journal, January 2015

Thermoplastic microfluidic bioreactors with integrated electrodes to study tumor treating fields on yeast cells
journal, May 2020

Cartridge systems, capacitive pumps and multi-throw valves and pump-valve systems and applications of same
patent, October 2021

Monolithic Microfabricated Valves and Pumps by Multilayer Soft Lithography
journal, April 2000

Integrated organ-on-chip systems and applications of the same
patent, September 2018

In situ Raman spectroscopy for simultaneous monitoring of multiple process parameters in mammalian cell culture bioreactors
journal, July 2012

The microfluidic multitrap nanophysiometer for hematologic cancer cell characterization reveals temporal sensitivity of the calcein-AM efflux assay
journal, May 2014

Characterization and comparison of ATF and TFF in stirred bioreactors for continuous mammalian cell culture processes
journal, June 2016

Microfluidic Large-Scale Integration
journal, September 2002

Vacuum membrane pump and a head portion for a vacuum membrane pump
patent, March 1999

High-throughput biological screening
patent, April 2015

Shear contributions to cell culture performance and product recovery in ATF and TFF perfusion systems
journal, March 2017

Raman spectroscopy compatible PDMS droplet microfluidic culture and analysis platform towards on-chip lipidomics
journal, January 2017

Real time monitoring of multiple parameters in mammalian cell culture bioreactors using an in-line Raman spectroscopy probe
journal, December 2010

Integrated organ-on-chip systems and applications of the same
patent, October 2019

Microfluidic systems for extracting nucleic acids for DNA and RNA analysis
journal, February 2007

Multichamber multipotentiostat system for cellular microphysiometry
journal, December 2014

Organ on chip integration and applications of the same
patent, January 2018

Microfluidic Cell Retention Device for Perfusion of Mammalian Suspension Culture
journal, July 2017

Air pump with improved air intake control structure
patent, October 2010

Raman Spectroscopy Detects Biochemical Changes Due to Proliferation in Mammalian Cell Cultures
journal, June 2005

Variation in diffusion of gases through PDMS due to plasma surface treatment and storage conditions
journal, September 2013

Description of the Chemostat
journal, December 1950

Cheaper faster drug development validated by the repositioning of drugs against neglected tropical diseases
journal, March 2015

Quantitative monitoring of yeast fermentation using Raman spectroscopy
journal, July 2014

Alternating flow filtration as an alternative to internal spin filter based perfusion process: Impact on productivity and product quality
journal, May 2017

Advances in blood–brain barrier modeling in microphysiological systems highlight critical differences in opioid transport due to cortisol exposure
journal, June 2020

Membrane-less microfiltration using inertial microfluidics
journal, July 2015

Valve with flexible sheet member
patent, August 1989

Real-Time Cellular Exometabolome Analysis with a Microfluidic-Mass Spectrometry Platform
journal, February 2015

The Robot Scientist Adam
journal, August 2009

A Dual-Column Solid Phase Extraction Strategy for Online Collection and Preparation of Continuously Flowing Effluent Streams for Mass Spectrometry
journal, September 2012

Slanted spiral microfluidics for the ultra-fast, label-free isolation of circulating tumor cells
journal, January 2014

Integrated human organ-on-chip microphysiological systems
patent, August 2017

Super-enhanced particle focusing in a novel microchannel geometry using inertial microfluidics
journal, April 2017

Device and methods for detecting the response of a plurality of cells to at least one analyte of interest
patent, May 2010

Real-Time Monitoring of Cellular Bioenergetics with a Multianalyte Screen-Printed Electrode
journal, July 2015

Experiments with the Chemostat on Spontaneous Mutations of Bacteria
journal, December 1950

The Automation of Science
journal, April 2009

Closed-loop cycles of experiment design, execution, and learning accelerate systems biology model development in yeast
journal, August 2019

Modeling the measurements of cellular fluxes in microbioreactor devices using thin enzyme electrodes
journal, October 2010

Integrating advanced functionality in a microfabricated high-throughput fluorescent-activated cell sorter
journal, January 2003

Interconnections of multiple perfused engineered tissue constructs and microbioreactors, multi-microformulators and applications of the same
patent, July 2018

Towards monitoring real-time cellular response using an integrated microfluidics-matrix assisted laser desorption ionisation/nanoelectrospray ionisation-ion mobility-mass spectrometry platform
journal, November 2010

Metabolic Discrimination of Select List Agents by Monitoring Cellular Responses in a Multianalyte Microphysiometer
journal, March 2009

A bistable, multiport valve enables microformulators creating microclinical analyzers that reveal aberrant glutamate metabolism in astrocytes derived from a tuberous sclerosis patient
journal, August 2021

Perfusion mammalian cell culture for recombinant protein manufacturing – A critical review
journal, July 2018

Conformational Ordering of Biomolecules in the Gas Phase: Nitrogen Collision Cross Sections Measured on a Prototype High Resolution Drift Tube Ion Mobility-Mass Spectrometer
journal, February 2014

Continuous culture - making a comeback?
journal, October 2005

Analysis of chemometric models applied to Raman spectroscopy for monitoring key metabolites of cell culture
journal, February 2020

An Integrated Raman Spectroscopy and Mass Spectrometry Platform to Study Single-Cell Drug Uptake, Metabolism, and Effects
journal, January 2020

Apparatus and methods for monitoring the status of a metabolically active cell
patent, April 2010

Peristaltic micropump and related systems and methods
patent, November 2019

Modification of the Cytosensor™ microphysiometer to simultaneously measure extracellular acidification and oxygen consumption rates
journal, October 2003