DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Lanthanide-chelator combinatorial barcoding

Abstract

Disclosed herein are methods for tracking solutions, (e.g., reaction conditions in solutions). In some embodiments, the method comprises: contacting a first lanthanide-chelator complex to a first solution to generate a first barcoded solution, wherein the first lanthanide-chelator complex comprises a first lanthanide chelated by a first chelator; contacting a second lanthanide-chelator complex to a second solution to generate a second barcoded solution, wherein the second lanthanide-chelator complex comprises a second lanthanide chelated by a second chelator; mixing the first barcoded solution and the second barcoded solution to form one or more mixtures; and identifying the first lanthanide ions in the mass spectrum and the second lanthanide ions in the mass spectrum to track the condition of each of the one or more mixtures.

Inventors:
; ; ;
Issue Date:
Research Org.:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
2222252
Patent Number(s):
11738321
Application Number:
15/611,662
Assignee:
The Regents of the University of California (Oakland, CA); National Technology & Engineering Solutions of Sandia, LLC (Albuquerque, NM)
DOE Contract Number:  
AC02-05CH11231
Resource Type:
Patent
Resource Relation:
Patent File Date: 06/01/2017
Country of Publication:
United States
Language:
English

Citation Formats

Duncombe, Todd, Northen, Trent R., Deng, Kai, and Singh, Anup K. Lanthanide-chelator combinatorial barcoding. United States: N. p., 2023. Web.
Duncombe, Todd, Northen, Trent R., Deng, Kai, & Singh, Anup K. Lanthanide-chelator combinatorial barcoding. United States.
Duncombe, Todd, Northen, Trent R., Deng, Kai, and Singh, Anup K. Tue . "Lanthanide-chelator combinatorial barcoding". United States. https://www.osti.gov/servlets/purl/2222252.
@article{osti_2222252,
title = {Lanthanide-chelator combinatorial barcoding},
author = {Duncombe, Todd and Northen, Trent R. and Deng, Kai and Singh, Anup K.},
abstractNote = {Disclosed herein are methods for tracking solutions, (e.g., reaction conditions in solutions). In some embodiments, the method comprises: contacting a first lanthanide-chelator complex to a first solution to generate a first barcoded solution, wherein the first lanthanide-chelator complex comprises a first lanthanide chelated by a first chelator; contacting a second lanthanide-chelator complex to a second solution to generate a second barcoded solution, wherein the second lanthanide-chelator complex comprises a second lanthanide chelated by a second chelator; mixing the first barcoded solution and the second barcoded solution to form one or more mixtures; and identifying the first lanthanide ions in the mass spectrum and the second lanthanide ions in the mass spectrum to track the condition of each of the one or more mixtures.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2023},
month = {8}
}

Works referenced in this record:

Detection and quantification of modified proteins
patent, March 2014


Microscale sample deposition onto hydrophobic target plates for trace level detection of neuropeptides in brain tissue by MALDI‐MS
journal, October 2005


Peptide labeling with lanthanide-NHS-ester-DOTA investigated by nano-HPLC
journal, January 2015


Characterization of metal‐labelled peptides by matrix‐assisted laser desorption/ionization mass spectrometry and tandem mass spectrometry
journal, October 2010


Prestructured MALDI-MS Sample Supports
journal, July 2000


Sample stacking of an extremely large injection volume in high-performance capillary electrophoresis
journal, May 1992


Polymer backbone element tags
patent, April 2015


Lanthanide-Containing Polymer Nanoparticles for Biological Tagging Applications:  Nonspecific Endocytosis and Cell Adhesion
journal, November 2007


Sensing Lanthanide Metal Content in Biological Tissues with Magnetic Resonance Spectroscopy
journal, October 2013


Luminescent lanthanide chelates and methods of use
patent, April 1997


High-Throughput, Microarray-Based Synthesis of Natural Product Analogues via in Vitro Metabolic Pathway Construction
journal, May 2007


Rationally reduced libraries for combinatorial pathway optimization minimizing experimental effort
journal, March 2016


Atomic weights of the elements 2013 (IUPAC Technical Report)
journal, March 2016


ICP-MS DNA assay based on lanthanide labels and hybridization chain reaction amplification
journal, January 2015