Multimodal nonlinear optical imaging via evanescent wave excitation
Abstract
A system for multimodal nonlinear optical imaging is provided. Each mode uses a high NA objective to cause total internal reflection excitation at a sample-substrate interface. The system has a femtosecond oscillator to generate pulses used for two beams. The objective receives at least one beam, redirects the received at least one beam through a dielectric substrate to cause the TIR and produces corresponding evanescent waves in a portion of the sample adjacent to the sample-substrate interface, and collects a backward-propagating beam of pulses of responsive light. The portion of the sample illuminated by the evanescent waves emits responsive light. Different modes or combinations of the distinct modalities may be selected to access complementary chemical and structural information for various chemical species near the sample-substrate interface. Each mode may have mode-specific control such as selective beam blocking, power ratios and filtering.
- Inventors:
- Issue Date:
- Research Org.:
- Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 2222230
- Patent Number(s):
- 11740182
- Application Number:
- 17/726,906
- Assignee:
- UT-Battelle, LLC (Oak Ridge, TN)
- DOE Contract Number:
- AC05-00OR22725
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 04/22/2022
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Doughty, Benjamin L., Ma, Yingzhong, and Premadasa, Uvinduni. Multimodal nonlinear optical imaging via evanescent wave excitation. United States: N. p., 2023.
Web.
Doughty, Benjamin L., Ma, Yingzhong, & Premadasa, Uvinduni. Multimodal nonlinear optical imaging via evanescent wave excitation. United States.
Doughty, Benjamin L., Ma, Yingzhong, and Premadasa, Uvinduni. Tue .
"Multimodal nonlinear optical imaging via evanescent wave excitation". United States. https://www.osti.gov/servlets/purl/2222230.
@article{osti_2222230,
title = {Multimodal nonlinear optical imaging via evanescent wave excitation},
author = {Doughty, Benjamin L. and Ma, Yingzhong and Premadasa, Uvinduni},
abstractNote = {A system for multimodal nonlinear optical imaging is provided. Each mode uses a high NA objective to cause total internal reflection excitation at a sample-substrate interface. The system has a femtosecond oscillator to generate pulses used for two beams. The objective receives at least one beam, redirects the received at least one beam through a dielectric substrate to cause the TIR and produces corresponding evanescent waves in a portion of the sample adjacent to the sample-substrate interface, and collects a backward-propagating beam of pulses of responsive light. The portion of the sample illuminated by the evanescent waves emits responsive light. Different modes or combinations of the distinct modalities may be selected to access complementary chemical and structural information for various chemical species near the sample-substrate interface. Each mode may have mode-specific control such as selective beam blocking, power ratios and filtering.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2023},
month = {8}
}
Works referenced in this record:
Hyperspectral Imaging and Characterization of Live Cells by Broadband Coherent Anti-Stokes Raman Scattering (CARS) Microscopy with Singular Value Decomposition (SVD) Analysis
journal, October 2014
- Khmaladze, Alexander; Jasensky, Joshua; Price, Erika
- Applied Spectroscopy, Vol. 68, Issue 10
Wide-field coherent anti-Stokes Raman scattering microscopy based on picosecond supercontinuum source
journal, November 2018
- Shen, Yujie; Wang, Jizhou; Wang, Kai
- APL Photonics, Vol. 3, Issue 11
Spectral focusing: High spectral resolution spectroscopy with broad-bandwidth laser pulses
journal, July 2004
- Hellerer, Thomas; Enejder, Annika M. K.; Zumbusch, Andreas
- Applied Physics Letters, Vol. 85, Issue 1
Elucidation of Perovskite Film Micro-Orientations Using Two-Photon Total Internal Reflectance Fluorescence Microscopy
journal, July 2015
- Watson, Brianna R.; Yang, Bin; Xiao, Kai
- The Journal of Physical Chemistry Letters, Vol. 6, Issue 16
Broadband Coherent Raman Scattering Microscopy
journal, July 2018
- Polli, Dario; Kumar, Vikas; Valensise, Carlo M.
- Laser & Photonics Reviews, Vol. 12, Issue 9
Implementing the Theory of Sum Frequency Generation Vibrational Spectroscopy: A Tutorial Review
journal, May 2005
- Lambert, Alex G.; Davies, Paul B.; Neivandt, David J.
- Applied Spectroscopy Reviews, Vol. 40, Issue 2
On illumination schemes for wide-field CARS microscopy
journal, January 2009
- Toytman, I.; Simanovskii, D.; Palanker, D.
- Optics Express, Vol. 17, Issue 9
Optimally chirped multimodal CARS microscopy based on a single Ti:sapphire oscillator
journal, January 2009
- Pegoraro, Adrian F.; Ridsdale, Andrew; Moffatt, Douglas J.
- Optics Express, Vol. 17, Issue 4
Wide-field coherent anti-Stokes Raman scattering microscopy
journal, February 2004
- Heinrich, Christoph; Bernet, Stefan; Ritsch-Marte, Monika
- Applied Physics Letters, Vol. 84, Issue 5
Surface-enhanced coherent anti-Stokes Raman imaging of lipids
journal, January 2016
- Fast, Alexander; Kenison, John P.; Syme, Christopher D.
- Applied Optics, Vol. 55, Issue 22
High-speed polarization-resolved coherent Raman scattering imaging
journal, January 2017
- Hofer, Matthias; Balla, Naveen K.; Brasselet, Sophie
- Optica, Vol. 4, Issue 7
Total internal reflection enabled wide-field coherent anti-Stokes Raman scattering microscopy
journal, January 2020
- Doughty, Benjamin; Premadasa, Uvinduni I.; Cahill, John F.
- Optics Letters, Vol. 45, Issue 11
Leaving the Limits of Linearity for Light Microscopy
journal, September 2020
- Blake, Marea J.; Colon, Brandon A.; Calhoun, Tessa R.
- The Journal of Physical Chemistry C, Vol. 124, Issue 45
Selective imaging of saturated and unsaturated lipids by wide-field CARS-microscopy
journal, January 2008
- Heinrich, Christoph; Hofer, Alexander; Ritsch, Andreas
- Optics Express, Vol. 16, Issue 4
Multimodal nonlinear optical microscopy
journal, March 2011
- Yue, S.; Slipchenko, M. N.; Cheng, J. -X.
- Laser & Photonics Reviews, Vol. 5, Issue 4
Wide-field vibrational phase imaging in an extremely folded box-CARS geometry
journal, January 2013
- Berto, Pascal; Jesacher, Alexander; Roider, Clemens
- Optics Letters, Vol. 38, Issue 5
Two-Photon Evanescent-Volume Wave Spectroscopy: A New Account of Gas-Solid Dynamics in the Boundary Layer
journal, February 2001
- Bordo, V. G.; Loerke, J.; Rubahn, H. -G.
- Physical Review Letters, Vol. 86, Issue 8
Principles of two-photon excitation fluorescence microscopy and other nonlinear imaging approaches
journal, October 2006
- Oheim, Martin; Michael, Darren J.; Geisbauer, Matthias
- Advanced Drug Delivery Reviews, Vol. 58, Issue 7
Energetics at the Surface: Direct Optical Mapping of Core and Surface Electronic Structure in CdSe Quantum Dots Using Broadband Electronic Sum Frequency Generation Microspectroscopy
journal, August 2019
- Watson, Brianna R.; Doughty, Benjamin; Calhoun, Tessa R.
- Nano Letters, Vol. 19, Issue 9