Apolipoprotein nanodiscs with telodendrimer
Abstract
The present invention provides a nanodisc with a membrane scaffold protein. The nanodisc includes a membrane scaffold protein, a telodendrimer and a lipid. The membrane scaffold protein can be apolipoprotein. The telodendrimer has the general formula PEG-L-D-(R)n, wherein D is a dendritic polymer; L is a bond or a linker linked to the focal point group of the dendritic polymer; each PEG is a poly(ethylene glycol) polymer, each R is and end group of the dendritic polymer, or and end group with a covalently bound hydrophobic group, hydrophilic group, amphiphilic compound, or drug; and subscript n is an integer from 2 to 20. Cell free methods of making the nanodiscs are also provided.
- Inventors:
- Issue Date:
- Research Org.:
- Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
- Sponsoring Org.:
- USDOE; National Institutes of Health (NIH)
- OSTI Identifier:
- 2222026
- Patent Number(s):
- 11713359
- Application Number:
- 17/308,921
- Assignee:
- Lawrence Livermore National Security, LLC (Livermore, CA)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
- DOE Contract Number:
- AC52-07NA27344; R01CA115483
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 05/05/2021
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Luo, Juntao, He, Wei, Lam, Kit S., Henderson, Paul, and Coleman, Matthew A. Apolipoprotein nanodiscs with telodendrimer. United States: N. p., 2023.
Web.
Luo, Juntao, He, Wei, Lam, Kit S., Henderson, Paul, & Coleman, Matthew A. Apolipoprotein nanodiscs with telodendrimer. United States.
Luo, Juntao, He, Wei, Lam, Kit S., Henderson, Paul, and Coleman, Matthew A. Tue .
"Apolipoprotein nanodiscs with telodendrimer". United States. https://www.osti.gov/servlets/purl/2222026.
@article{osti_2222026,
title = {Apolipoprotein nanodiscs with telodendrimer},
author = {Luo, Juntao and He, Wei and Lam, Kit S. and Henderson, Paul and Coleman, Matthew A.},
abstractNote = {The present invention provides a nanodisc with a membrane scaffold protein. The nanodisc includes a membrane scaffold protein, a telodendrimer and a lipid. The membrane scaffold protein can be apolipoprotein. The telodendrimer has the general formula PEG-L-D-(R)n, wherein D is a dendritic polymer; L is a bond or a linker linked to the focal point group of the dendritic polymer; each PEG is a poly(ethylene glycol) polymer, each R is and end group of the dendritic polymer, or and end group with a covalently bound hydrophobic group, hydrophilic group, amphiphilic compound, or drug; and subscript n is an integer from 2 to 20. Cell free methods of making the nanodiscs are also provided.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2023},
month = {8}
}
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