Synthetic anti-plague antibodies
Abstract
Monoclonal antibodies that specifically bind the F1 antigen of Yersinia pestis with high affinity are described. Use of the monoclonal antibodies for the detection of Y. pestis infection and the diagnosis of plague are also described. Immunoconjugates of the monoclonal antibodies and a radionuclide can also be used for the treatment of a Y. pestis infection.
- Inventors:
- Issue Date:
- Research Org.:
- Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
- Sponsoring Org.:
- USDOE National Nuclear Security Administration (NNSA)
- OSTI Identifier:
- 2221978
- Patent Number(s):
- 11702465
- Application Number:
- 17/033,516
- Assignee:
- Triad National Security, LLC (Los Alamos, NM)
- DOE Contract Number:
- 89233218CNA000001
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 09/25/2020
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Lillo, Antonietta Maria, Velappan, Nileena, Dichosa, Armand Earl Ko, Kozimor, Stosh Anthony, and Lilley, Laura Margaret. Synthetic anti-plague antibodies. United States: N. p., 2023.
Web.
Lillo, Antonietta Maria, Velappan, Nileena, Dichosa, Armand Earl Ko, Kozimor, Stosh Anthony, & Lilley, Laura Margaret. Synthetic anti-plague antibodies. United States.
Lillo, Antonietta Maria, Velappan, Nileena, Dichosa, Armand Earl Ko, Kozimor, Stosh Anthony, and Lilley, Laura Margaret. Tue .
"Synthetic anti-plague antibodies". United States. https://www.osti.gov/servlets/purl/2221978.
@article{osti_2221978,
title = {Synthetic anti-plague antibodies},
author = {Lillo, Antonietta Maria and Velappan, Nileena and Dichosa, Armand Earl Ko and Kozimor, Stosh Anthony and Lilley, Laura Margaret},
abstractNote = {Monoclonal antibodies that specifically bind the F1 antigen of Yersinia pestis with high affinity are described. Use of the monoclonal antibodies for the detection of Y. pestis infection and the diagnosis of plague are also described. Immunoconjugates of the monoclonal antibodies and a radionuclide can also be used for the treatment of a Y. pestis infection.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2023},
month = {7}
}
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Works referenced in this record:
Development of Phage-Based Single Chain Fv Antibody Reagents for Detection of Yersinia pestis
journal, December 2011
- Lillo, Antonietta M.; Ayriss, Joanne E.; Shou, Yulin
- PLoS ONE, Vol. 6, Issue 12