Flash radiotherapy accelerator

Sampayan, Stephen E.; Sampayan, Kristin Cortella; Caporaso, George James; Chen, Yu-Jiuan; Shang, Clifford C.

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Title: Flash radiotherapy accelerator

Abstract

Methods, devices and systems for ultra-high dose radiotherapy are disclosed. The described techniques rely in-part on active switching control of a photoconductive switch during the time the accelerator is accelerating charged particles to produce the output radiation at the desired dose rates. One flash radiotherapy system includes an induction accelerator, and a controllable switch coupled to the induction accelerator. The switch is operable to produce a plurality of voltage pulses to drive the induction accelerator. The radiotherapy system also includes a radiation measurement device to measure output radiation produced by the radiotherapy system and provide feedback to the controllable switch. The controllable switch is operable to, based on the received feedback, modify an amplitude, shape, spacing, number or width of the voltage pulses that are supplied to the particle accelerator to deliver the desired output radiation.

Inventors:: Sampayan, Stephen E.; Sampayan, Kristin Cortella; Caporaso, George James; Chen, Yu-Jiuan; Shang, Clifford C.

Issue Date:: 2023-07-11

Research Org.:: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 2221957

Patent Number(s):: 11697032

Application Number:: 17/559,776

Assignee:: Lawrence Livermore National Security, LLC (Livermore, CA); Opcondys, Inc. (Manteca, CA)

DOE Contract Number:: AC52-07NA27344

Resource Type:: Patent

Resource Relation:: Patent File Date: 12/22/2021

Country of Publication:: United States

Language:: English

Citation Formats


                    Sampayan, Stephen E., Sampayan, Kristin Cortella, Caporaso, George James, Chen, Yu-Jiuan, and Shang, Clifford C. Flash radiotherapy accelerator.  United States: N. p., 2023. 
        Web.

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                    Sampayan, Stephen E., Sampayan, Kristin Cortella, Caporaso, George James, Chen, Yu-Jiuan, & Shang, Clifford C. Flash radiotherapy accelerator.  United States.

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                    Sampayan, Stephen E., Sampayan, Kristin Cortella, Caporaso, George James, Chen, Yu-Jiuan, and Shang, Clifford C. Tue .  
        "Flash radiotherapy accelerator".  United States.  https://www.osti.gov/servlets/purl/2221957.

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@article{osti_2221957,

  title        = {Flash radiotherapy accelerator},

  author       = {Sampayan, Stephen E. and Sampayan, Kristin Cortella and Caporaso, George James and Chen, Yu-Jiuan and Shang, Clifford C.},

  abstractNote = {Methods, devices and systems for ultra-high dose radiotherapy are disclosed. The described techniques rely in-part on active switching control of a photoconductive switch during the time the accelerator is accelerating charged particles to produce the output radiation at the desired dose rates. One flash radiotherapy system includes an induction accelerator, and a controllable switch coupled to the induction accelerator. The switch is operable to produce a plurality of voltage pulses to drive the induction accelerator. The radiotherapy system also includes a radiation measurement device to measure output radiation produced by the radiotherapy system and provide feedback to the controllable switch. The controllable switch is operable to, based on the received feedback, modify an amplitude, shape, spacing, number or width of the voltage pulses that are supplied to the particle accelerator to deliver the desired output radiation.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2023},

  month        = {7}

}

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Works referenced in this record:

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Similar Records

Title: Flash radiotherapy accelerator

Abstract

Citation Formats

Operation of a Six-Mev Linear Electron Accelerator journal, June 1951

Induction voltage adders and the induction accelerator family journal, June 2004

The Effects of Ultra-High Dose Rate Proton Irradiation on Growth Delay in the Treatment of Human Tumor Xenografts in Nude Mice journal, February 2014

The acceleration of large current pulses in electron linear accelerators journal, January 1962

Irradiation of materials with short, intense ion pulses at NDCX-II journal, May 2017

Characterization of carrier behavior in photonically excited 6H silicon carbide exhibiting fast, high voltage, bulk transconductance properties journal, March 2021

Induction linear accelerators conference, January 1992

Linear induction accelerator and pulse forming networks therefor patent, December 1989

High Current Linear Induction Accelerator for Electrons journal, July 1964

The NDCX-II engineering design journal, January 2014

Induction accelerator architectures for heavy-ion fusion journal, September 1998

Electron beam accelerator with magnetic pulse compression and accelerator switching patent, February 1987

A compact linac for intensity modulated proton therapy based on a dielectric wall accelerator journal, June 2008

A hybrid solid state induction modulator for klystrons conference, June 2007

Modulator for generating high voltage pulses patent, May 2000

The Advanced Test Accelerator (ATA), a 50-MeV, 10-kA Induction Linac journal, August 1983

High voltage inductive adder patent, May 2019

DAHRT accelerators update and plans for initial operation conference, January 1999

The Stanford Mark II Linear Accelerator journal, February 1955

Beam Transport System and Method for Linear Accelerators patent-application, September 2009

A Linear Electron Accelerator journal, February 1948

Charged Particle Beam Scanning Using Deformed High Gradient Insulator patent-application, June 2013

Tomotherapy: A new concept for the delivery of dynamic conformal radiotherapy journal, November 1993

Mathematical theory and calculations of magnetic hysteresis curves journal, January 1988

Treatment of a first patient with FLASH-radiotherapy journal, October 2019

Ultra-High Dose Rate (FLASH) Radiotherapy: Silver Bullet or Fool's Gold? journal, January 2020

High gradient linac for proton therapy journal, April 2017

Über ein neues Prinzip zur Herstellung hoher Spannungen journal, July 1928

Recent Performance Improvements on FXR journal, August 1983

Charged particle cancer therapy beam state determination system and method of use thereof patent, October 2020

Slow-Scale and Fast-Scale Instabilities in Parallel-Connected Single-Phase H-Bridge Inverters: A Design-Oriented Study journal, January 2020

Advances in linear accelerator design for radiotherapy journal, March 1984

High radiation dose rates may improve cancer therapy journal, December 2020

The Astron Linear Accelerator journal, June 1969

Compact accelerator for medical therapy patent, May 2010

FLASH radiotherapy: Newsflash or flash in the pan? journal, August 2019

Wide Bandgap Photoconductive Switches Driven by Laser Diodes as a High-Voltage Mosfet Replacement for Bioelectrics and Accelerator Applications conference, June 2019

Asymptotic Theory of Beam Break‐Up in Linear Accelerators journal, February 1968

Multilayer high gradient insulator technology journal, June 2000

The induction-FEL design for the white sands missile range journal, October 1990

The Advantage of FLASH Radiotherapy Confirmed in Mini-pig and Cat-cancer Patients journal, June 2018

The design and testing of an inductive voltage adder for ALS-U kicker magnets conference, July 2016

Design of Linear Electron Accelerators with Beam Loading journal, July 1958

PHASER: A platform for clinical translation of FLASH cancer radiotherapy journal, October 2019

Modern compact accelerators of cyclotron type for medical applications journal, September 2016

Stability analysis of parallel DC-DC converters journal, January 2006

Irradiation in a flash: Unique sparing of memory in mice after whole brain irradiation with dose rates above 100 Gy/s journal, September 2017

Bi-directional, transformerless voltage system patent, April 2019

Extended Theory of Beam Loading in Electron Linac journal, June 1993

Experimental Platform for Ultra-high Dose Rate FLASH Irradiation of Small Animals Using a Clinical Linear Accelerator journal, January 2017

High dose-per-pulse electron beam dosimetry: Commissioning of the Oriatron eRT6 prototype linear accelerator for preclinical use journal, January 2018

Operation of a Six-Mev Linear Electron Accelerator
journal, June 1951

Induction voltage adders and the induction accelerator family
journal, June 2004

The Effects of Ultra-High Dose Rate Proton Irradiation on Growth Delay in the Treatment of Human Tumor Xenografts in Nude Mice
journal, February 2014

The acceleration of large current pulses in electron linear accelerators
journal, January 1962

Irradiation of materials with short, intense ion pulses at NDCX-II
journal, May 2017

Characterization of carrier behavior in photonically excited 6H silicon carbide exhibiting fast, high voltage, bulk transconductance properties
journal, March 2021

Induction linear accelerators
conference, January 1992

Linear induction accelerator and pulse forming networks therefor
patent, December 1989

High Current Linear Induction Accelerator for Electrons
journal, July 1964

The NDCX-II engineering design
journal, January 2014

Induction accelerator architectures for heavy-ion fusion
journal, September 1998

Electron beam accelerator with magnetic pulse compression and accelerator switching
patent, February 1987

A compact linac for intensity modulated proton therapy based on a dielectric wall accelerator
journal, June 2008

A hybrid solid state induction modulator for klystrons
conference, June 2007

Modulator for generating high voltage pulses
patent, May 2000

The Advanced Test Accelerator (ATA), a 50-MeV, 10-kA Induction Linac
journal, August 1983

High voltage inductive adder
patent, May 2019

DAHRT accelerators update and plans for initial operation
conference, January 1999

The Stanford Mark II Linear Accelerator
journal, February 1955

Beam Transport System and Method for Linear Accelerators
patent-application, September 2009

A Linear Electron Accelerator
journal, February 1948

Charged Particle Beam Scanning Using Deformed High Gradient Insulator
patent-application, June 2013

Tomotherapy: A new concept for the delivery of dynamic conformal radiotherapy
journal, November 1993

Mathematical theory and calculations of magnetic hysteresis curves
journal, January 1988

Treatment of a first patient with FLASH-radiotherapy
journal, October 2019

Ultra-High Dose Rate (FLASH) Radiotherapy: Silver Bullet or Fool's Gold?
journal, January 2020

High gradient linac for proton therapy
journal, April 2017

Über ein neues Prinzip zur Herstellung hoher Spannungen
journal, July 1928

Recent Performance Improvements on FXR
journal, August 1983

Charged particle cancer therapy beam state determination system and method of use thereof
patent, October 2020

Slow-Scale and Fast-Scale Instabilities in Parallel-Connected Single-Phase H-Bridge Inverters: A Design-Oriented Study
journal, January 2020

Advances in linear accelerator design for radiotherapy
journal, March 1984

High radiation dose rates may improve cancer therapy
journal, December 2020

The Astron Linear Accelerator
journal, June 1969

Compact accelerator for medical therapy
patent, May 2010

FLASH radiotherapy: Newsflash or flash in the pan?
journal, August 2019

Wide Bandgap Photoconductive Switches Driven by Laser Diodes as a High-Voltage Mosfet Replacement for Bioelectrics and Accelerator Applications
conference, June 2019

Asymptotic Theory of Beam Break‐Up in Linear Accelerators
journal, February 1968

Multilayer high gradient insulator technology
journal, June 2000

The induction-FEL design for the white sands missile range
journal, October 1990

The Advantage of FLASH Radiotherapy Confirmed in Mini-pig and Cat-cancer Patients
journal, June 2018

The design and testing of an inductive voltage adder for ALS-U kicker magnets
conference, July 2016

Design of Linear Electron Accelerators with Beam Loading
journal, July 1958

PHASER: A platform for clinical translation of FLASH cancer radiotherapy
journal, October 2019

Modern compact accelerators of cyclotron type for medical applications
journal, September 2016

Stability analysis of parallel DC-DC converters
journal, January 2006

Irradiation in a flash: Unique sparing of memory in mice after whole brain irradiation with dose rates above 100 Gy/s
journal, September 2017

Bi-directional, transformerless voltage system
patent, April 2019

Extended Theory of Beam Loading in Electron Linac
journal, June 1993

Experimental Platform for Ultra-high Dose Rate FLASH Irradiation of Small Animals Using a Clinical Linear Accelerator
journal, January 2017

High dose-per-pulse electron beam dosimetry: Commissioning of the Oriatron eRT6 prototype linear accelerator for preclinical use
journal, January 2018