Microscale device and method for purification of radiopharmaceuticals
Abstract
A microfluidic chip device for the purification of radiochemical compounds includes a chip having an injection channel and intersecting branch channels with a plurality of valves are located along the injection channel and branch channels and configured to retain a plug of solution containing the radiochemical compound. The chip further includes a serpentine channel segment (for separation) coupled to the output of the injection channel. A high voltage power source advances the plug of solution through the purification region and into the downstream fraction collection channel. The chip includes a downstream fraction collection channel coupled to the serpentine channel segment and having an optical and radiation detection regions. One or more branch fraction channels intersect with the fraction collection channel and include valves located therein so that the radiochemical compound that is detected using a radiation detector is directed into the desired branch fraction channel for subsequent use.
- Inventors:
- Issue Date:
- Research Org.:
- Univ. of California, Los Angeles, CA (United States)
- Sponsoring Org.:
- USDOE; National Institutes of Health (NIH)
- OSTI Identifier:
- 1998434
- Patent Number(s):
- 11660571
- Application Number:
- 16/461,272
- Assignee:
- The Regents of the University of California (Oakland, CA)
- DOE Contract Number:
- SC0001249; AG049918
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 11/14/2017
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Van Dam, R. Michael, Ha, Noel S., Jones, Jason, Ly, Jimmy, Liu, Stephen, and Cheung, Shilin. Microscale device and method for purification of radiopharmaceuticals. United States: N. p., 2023.
Web.
Van Dam, R. Michael, Ha, Noel S., Jones, Jason, Ly, Jimmy, Liu, Stephen, & Cheung, Shilin. Microscale device and method for purification of radiopharmaceuticals. United States.
Van Dam, R. Michael, Ha, Noel S., Jones, Jason, Ly, Jimmy, Liu, Stephen, and Cheung, Shilin. Tue .
"Microscale device and method for purification of radiopharmaceuticals". United States. https://www.osti.gov/servlets/purl/1998434.
@article{osti_1998434,
title = {Microscale device and method for purification of radiopharmaceuticals},
author = {Van Dam, R. Michael and Ha, Noel S. and Jones, Jason and Ly, Jimmy and Liu, Stephen and Cheung, Shilin},
abstractNote = {A microfluidic chip device for the purification of radiochemical compounds includes a chip having an injection channel and intersecting branch channels with a plurality of valves are located along the injection channel and branch channels and configured to retain a plug of solution containing the radiochemical compound. The chip further includes a serpentine channel segment (for separation) coupled to the output of the injection channel. A high voltage power source advances the plug of solution through the purification region and into the downstream fraction collection channel. The chip includes a downstream fraction collection channel coupled to the serpentine channel segment and having an optical and radiation detection regions. One or more branch fraction channels intersect with the fraction collection channel and include valves located therein so that the radiochemical compound that is detected using a radiation detector is directed into the desired branch fraction channel for subsequent use.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2023},
month = {5}
}
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