CRISPR-Cas based system for targeting single-stranded sequences
Abstract
The present invention relates to a CRISPR-Cas based system for targeting nucleic acid sequences. In part, the invention relates to synthetic guiding components for targeting single-stranded sequences, as well as design principles for constructing such components. Also described herein are methods of employing such components, e.g., to repress or activate a desired target within the subject.
- Inventors:
- Issue Date:
- Research Org.:
- Sandia National Lab. (SNL-CA), Livermore, CA (United States); Univ. of California, Berkeley, CA (United States)
- Sponsoring Org.:
- USDOE National Nuclear Security Administration (NNSA); National Science Foundation (NSF)
- OSTI Identifier:
- 1998416
- Patent Number(s):
- 11661599
- Application Number:
- 16/219,779
- Assignee:
- National Technology & Engineering Solutions of Sandia, LLC (Albuquerque, NM); The Regents of the University of California (Oakland, CA)
- DOE Contract Number:
- NA0003525; MCB-1244557
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 12/13/2018
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Negrete, Oscar, Doudna, Jennifer A., and Strutt, Steven C. CRISPR-Cas based system for targeting single-stranded sequences. United States: N. p., 2023.
Web.
Negrete, Oscar, Doudna, Jennifer A., & Strutt, Steven C. CRISPR-Cas based system for targeting single-stranded sequences. United States.
Negrete, Oscar, Doudna, Jennifer A., and Strutt, Steven C. Tue .
"CRISPR-Cas based system for targeting single-stranded sequences". United States. https://www.osti.gov/servlets/purl/1998416.
@article{osti_1998416,
title = {CRISPR-Cas based system for targeting single-stranded sequences},
author = {Negrete, Oscar and Doudna, Jennifer A. and Strutt, Steven C.},
abstractNote = {The present invention relates to a CRISPR-Cas based system for targeting nucleic acid sequences. In part, the invention relates to synthetic guiding components for targeting single-stranded sequences, as well as design principles for constructing such components. Also described herein are methods of employing such components, e.g., to repress or activate a desired target within the subject.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2023},
month = {5}
}
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