Title: Controlling metabolism by substrate cofeeding

Abstract

The disclosure provides methods using mixed substrate cofeeding for bioproduct synthesis, which enables faster, more efficient, and higher yield carbon conversion in various organisms.

Inventors:

Park, Junyoung; Liu, Nian; Stephanopoulos, Gregory

Issue Date:

2023-05-16

Research Org.:

Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States)

Sponsoring Org.:

USDOE

OSTI Identifier:

1998387

Patent Number(s):

11649472

Application Number:

16/023,336

Assignee:

Massachusetts Institute of Technology (Cambridge, MA)

Patent Classifications (CPCs):

C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES

C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {

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C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES

C12N1/16 - Yeasts
C12N1/32 - Processes using, or culture media containing, lower alkanols, i.e. C1 to C6
C12N9/22 - Ribonucleases {RNAses, DNAses
C12N9/2437 - {Cellulases
C12N9/2474 - {Hyaluronoglucosaminidase

C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {

C12P7/54 - Acetic acid
C12P7/64 - Fats
C12P7/6409 - {Fatty acids}
C12P7/6463 - {obtained from glyceride producing microorganisms, e.g. single cell oil}

C - CHEMISTRY C12 - BIOCHEMISTRY C12Y - ENZYMES

C12Y302/01004 - Cellulase
C12Y302/01035 - Hyaluronoglucosaminidase

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DOE Contract Number:  

AR0000433; SC0008744; SC0012377

Resource Type:

Patent

Resource Relation:

Patent File Date: 06/29/2018

Country of Publication:

United States

Language:

English