Rapid droplet introduction interface (RDII) for mass spectrometry
Abstract
A system for the mass spectrometry analysis of an analyte includes a droplet ejection device, a spray head comprising a spray tip for ejecting the solvent as a spray, and a solvent delivery conduit for delivering solvent to the spray tip. The spray head includes a droplet inlet opening communicating with the surrounding atmosphere for receiving liquid droplets comprising the analyte. The droplet ejection device selectively ejects a liquid analyte droplet comprising the analyte through a surrounding atmosphere and the droplet inlet opening into a solvent flowing through the solvent delivery conduit. A method for the mass spectrometry analysis of an analyte is also disclosed.
- Inventors:
- Issue Date:
- Research Org.:
- Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1998379
- Patent Number(s):
- 11651945
- Application Number:
- 17/480,094
- Assignee:
- UT-Battelle, LLC (Oak Ridge, TN)
- DOE Contract Number:
- AC05-00OR22725
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 09/20/2021
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Kertesz, Vilmos, and Cahill, John F. Rapid droplet introduction interface (RDII) for mass spectrometry. United States: N. p., 2023.
Web.
Kertesz, Vilmos, & Cahill, John F. Rapid droplet introduction interface (RDII) for mass spectrometry. United States.
Kertesz, Vilmos, and Cahill, John F. Tue .
"Rapid droplet introduction interface (RDII) for mass spectrometry". United States. https://www.osti.gov/servlets/purl/1998379.
@article{osti_1998379,
title = {Rapid droplet introduction interface (RDII) for mass spectrometry},
author = {Kertesz, Vilmos and Cahill, John F.},
abstractNote = {A system for the mass spectrometry analysis of an analyte includes a droplet ejection device, a spray head comprising a spray tip for ejecting the solvent as a spray, and a solvent delivery conduit for delivering solvent to the spray tip. The spray head includes a droplet inlet opening communicating with the surrounding atmosphere for receiving liquid droplets comprising the analyte. The droplet ejection device selectively ejects a liquid analyte droplet comprising the analyte through a surrounding atmosphere and the droplet inlet opening into a solvent flowing through the solvent delivery conduit. A method for the mass spectrometry analysis of an analyte is also disclosed.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2023},
month = {5}
}
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Works referenced in this record:
Nano-electrospray ionization mass spectrometry: addressing analytical problems beyond routine
journal, March 2000
- Karas, M.; Bahr, U.; Dülcks, T.
- Fresenius' Journal of Analytical Chemistry, Vol. 366, Issue 6-7, p. 669-676
Mass Cytometry: Single Cells, Many Features
journal, May 2016
- Spitzer, Matthew H.; Nolan, Garry P.
- Cell, Vol. 165, Issue 4
Rapid, Untargeted Chemical Profiling of Single Cells in Their Native Environment
journal, April 2019
- Cahill, John F.; Riba, Julian; Kertesz, Vilmos
- Analytical Chemistry, Vol. 91, Issue 9
Apparatus and Method for Liquid Sample Introduction
patent-application, September 2014
- Hattingh, Ruan; Bird, Neil; Neal, Paul
- US Patent Application 14/163541; 20140283627
The Single-Probe: A Miniaturized Multifunctional Device for Single Cell Mass Spectrometry Analysis
journal, September 2014
- Pan, Ning; Rao, Wei; Kothapalli, Naga Rama
- Analytical Chemistry, Vol. 86, Issue 19
Direct infusion mass spectrometry or liquid chromatography mass spectrometry for human metabonomics? A serum metabonomic study of kidney cancer
journal, January 2010
- Lin, Lin; Yu, Quan; Yan, Xiaomei
- The Analyst, Vol. 135, Issue 11
Sample atomization with reduced clogging for analytical instruments
patent, October 2015
- Schleifer, Arthur
- US Patent Document 9,165,751
Method and Device for the Analysis of Living Reaction Media
patent-application, March 2007
- Reboud, Julien; Schaack, Beatrice; Chatelain, Francois
- US Patent Application 10/563817; 20070065946
Microspray Liquid-Liquid Extractive Ionization Device
patent-application, July 2008
- Chen, Huanwen; Chen, Hao; Venter, Andre
- US Patent Document 11/751718; 20080179511
Coupling Droplet Microfluidics with Mass Spectrometry for Ultrahigh-Throughput Analysis of Complex Mixtures up to and above 30 Hz
journal, July 2020
- Kempa, Emily E.; Smith, Clive A.; Li, Xin
- Analytical Chemistry, Vol. 92, Issue 18
Drop-on-Demand Sample Introduction System Coupled with the Flowing Atmospheric-Pressure Afterglow for Direct Molecular Analysis of Complex Liquid Microvolume Samples
journal, October 2012
- Schaper, J. Niklas; Pfeuffer, Kevin P.; Shelley, Jacob T.
- Analytical Chemistry, Vol. 84, Issue 21
Charged particle source with droplet control for mass spectrometry
patent, June 2005
- Berggren, William Travis; Westphall, Michael S.; Smith, Lloyd M.
- US Patent Document 6,906,322
Multimode ionization source
patent, February 2009
- Fischer, Steven; Gourley, Darrell L.; Bertsch, James L.
- US Patent Document 7,488,953
Guiding spray droplets into an inlet capillary of a mass spectrometer
patent, August 2013
- Franzen, Jochen; Koster, Claus
- US Patent Document 8,513,599
High-Throughput Nanoelectrospray Ionization-Mass Spectrometry Analysis of Microfluidic Droplet Samples
journal, April 2019
- Steyer, Daniel J.; Kennedy, Robert T.
- Analytical Chemistry, Vol. 91, Issue 10
An open port sampling interface for liquid introduction atmospheric pressure ionization mass spectrometry: Open port sampling interface
journal, August 2015
- Van Berkel, Gary J.; Kertesz, Vilmos
- Rapid Communications in Mass Spectrometry, Vol. 29, Issue 19
Rapid sample classification using an open port sampling interface coupled with liquid introduction atmospheric pressure ionization mass spectrometry: Sample classification using an open port sampling interface
journal, January 2017
- Van Berkel, Gary J.; Kertesz, Vilmos
- Rapid Communications in Mass Spectrometry, Vol. 31, Issue 3
Pulsed Nano-Electrospray Ionization: Characterization of Temporal Response and Implementation with a Flared Inlet Capillary
journal, April 2009
- Bushey, Jared M.; Kaplan, Desmond A.; Danell, Ryan M.
- Instrumentation Science & Technology, Vol. 37, Issue 3
Rapid Native Single Cell Mass Spectrometry
patent-application, June 2020
- Cahill, John F.
- US Patent Application 16/685740; 20200191794
Mass spectrometry based multi-parametric particle analyzer
patent, October 2019
- Bandura, Dmitry R.; Baranov, Vladimir; Tanner, Scott D.
- US Patent Document 10,436,698
Ambient infrared laser ablation mass spectrometry (AIRLAB-MS) with plume capture by continuous flow solvent probe
patent, October 2017
- O'Brien, Jeremy Thomas; Williams, Evan; Holman, Hoi-Ying N.
- US Patent Document 9,805,921
Method and apparatus for contained-electrospray for use in mass spectrometry and droplet reactions
patent, December 2017
- Badu-Tawiah, Abraham; Kulyk, Dmytro
- US Patent Document 9,852,896
Method of Processing Dried Samples Using Digital Microfluidic Device
patent-application, June 2013
- Jebrail, Mais J.; Yang, Hao; Wheeler, Aaron R.
- US Patent Application 13/695869; 20130164856
Photoionization mass spectrometer
patent, April 2001
- Syage, Jack A.; Hanold, Karl A.; Hanning-Lee, Mark A.
- US Patent Document 6,211,516
Immediate drop on demand technology (I-DOT) coupled with mass spectrometry via an open port sampling interface
journal, November 2017
- Van Berkel, Gary J.; Kertesz, Vilmos; Boeltz, Harry
- Bioanalysis, Vol. 9, Issue 21
Ultrahigh-Throughput ESI-MS: Sampling Pushed to Six Samples per Second by Acoustic Ejection Mass Spectrometry
journal, August 2020
- Häbe, Tim T.; Liu, Chang; Covey, Tom R.
- Analytical Chemistry, Vol. 92, Issue 18
Combined Falling Drop/Open Port Sampling Interface System for Automated Flow Injection Mass Spectrometry
journal, November 2017
- Van Berkel, Gary J.; Kertesz, Vilmos; Orcutt, Matt
- Analytical Chemistry, Vol. 89, Issue 22