Title: Targeted near-infrared imaging by metal-organic frameworks

Abstract

Metal-organic frameworks (MOFs) comprising amines on the organic linker can be used for cell targeting. In particular, primary amine groups represent one of the most versatile chemical moieties for conjugation to biologically relevant molecules, including antibodies and enzymes. Different chemical conjugation schemes can be used to conjugate biological molecules to the amino functionality on the organic linker. For example, carbodiimide chemistry can be used to link a primary amine to available carboxyl groups on the protein. For example, sulfhydryl crosslinking chemistry can be used via Traut's reagent scheme. As a demonstration of the invention, the ability of EpCAM antibody-targeted MOFs to bind to a human epithelial cell line (A549), a common target for imaging studies, was confirmed with confocal microscopy.

Inventors:

Sava Gallis, Dorina F.; Butler, Kimberly

Issue Date:

2023-05-09

Research Org.:

Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

Sponsoring Org.:

USDOE National Nuclear Security Administration (NNSA)

OSTI Identifier:

1998358

Patent Number(s):

11644462

Application Number:

17/243,417

Assignee:

National Technology & Engineering Solutions of Sandia, LLC (Albuquerque, NM)

DOE Contract Number:  

NA0003525

Resource Type:

Patent

Resource Relation:

Patent File Date: 04/28/2021

Country of Publication:

United States

Language:

English