System and process for purification of Astatine-211 from target materials
Abstract
A new column-based purification system and approach are described for rapid separation and purification of the alpha-emitting therapeutic radioisotope 211At from dissolved cyclotron targets that provide highly reproducible product results with excellent 211At species distributions and high antibody labeling yields compared with prior art manual extraction results of the prior art that can be expected to enable enhanced production of purified 211At isotope products suitable for therapeutic medical applications such as treatment of cancer in human patients.
- Inventors:
- Issue Date:
- Research Org.:
- Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1998263
- Patent Number(s):
- 11621097
- Application Number:
- 17/586,647
- Assignee:
- Battelle Memorial Institute (Richland, WA)
- DOE Contract Number:
- AC05-76RL01830
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 01/27/2022
- Country of Publication:
- United States
- Language:
- English
Citation Formats
O'Hara, Matthew J. System and process for purification of Astatine-211 from target materials. United States: N. p., 2023.
Web.
O'Hara, Matthew J. System and process for purification of Astatine-211 from target materials. United States.
O'Hara, Matthew J. Tue .
"System and process for purification of Astatine-211 from target materials". United States. https://www.osti.gov/servlets/purl/1998263.
@article{osti_1998263,
title = {System and process for purification of Astatine-211 from target materials},
author = {O'Hara, Matthew J.},
abstractNote = {A new column-based purification system and approach are described for rapid separation and purification of the alpha-emitting therapeutic radioisotope 211At from dissolved cyclotron targets that provide highly reproducible product results with excellent 211At species distributions and high antibody labeling yields compared with prior art manual extraction results of the prior art that can be expected to enable enhanced production of purified 211At isotope products suitable for therapeutic medical applications such as treatment of cancer in human patients.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2023},
month = {4}
}
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