Phosphorylated tri-block copolymers with antimicrobial properties
Abstract
The disclosure provides products and methods of treating diseases and disorders involving microbial pathogens, such as intestinal microbial pathogens, e.g., Pseudomonas aeruginosa, by administering an effective amount of a phosphorylated polyethylene glycol compound of defined structural organization. Those diseases and disorders characterized by an epithelium attacked by a microbial pathogen are contemplated, including gastrointestinal infections and inflammation, e.g., treatment of intestinal or esophageal anastomosis or treatment or suppression of anastomotic leakage.
- Inventors:
- Issue Date:
- Research Org.:
- Argonne National Laboratory (ANL), Argonne, IL (United States); Univ. of Chicago, IL (United States)
- Sponsoring Org.:
- USDOE; National Institutes of Health (NIH)
- OSTI Identifier:
- 1987100
- Patent Number(s):
- 11571443
- Application Number:
- 16/338,330
- Assignee:
- The University of Chicago (Chicago, IL)
- DOE Contract Number:
- AC02-06CH11357; R01GM062344
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 09/29/2017
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Alverdy, John C., Tirrell, Matthew, Zaborina, Olga Y., Mao, Jun, and Chen, Wei. Phosphorylated tri-block copolymers with antimicrobial properties. United States: N. p., 2023.
Web.
Alverdy, John C., Tirrell, Matthew, Zaborina, Olga Y., Mao, Jun, & Chen, Wei. Phosphorylated tri-block copolymers with antimicrobial properties. United States.
Alverdy, John C., Tirrell, Matthew, Zaborina, Olga Y., Mao, Jun, and Chen, Wei. Tue .
"Phosphorylated tri-block copolymers with antimicrobial properties". United States. https://www.osti.gov/servlets/purl/1987100.
@article{osti_1987100,
title = {Phosphorylated tri-block copolymers with antimicrobial properties},
author = {Alverdy, John C. and Tirrell, Matthew and Zaborina, Olga Y. and Mao, Jun and Chen, Wei},
abstractNote = {The disclosure provides products and methods of treating diseases and disorders involving microbial pathogens, such as intestinal microbial pathogens, e.g., Pseudomonas aeruginosa, by administering an effective amount of a phosphorylated polyethylene glycol compound of defined structural organization. Those diseases and disorders characterized by an epithelium attacked by a microbial pathogen are contemplated, including gastrointestinal infections and inflammation, e.g., treatment of intestinal or esophageal anastomosis or treatment or suppression of anastomotic leakage.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2023},
month = {2}
}
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