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Title: Engineered microorganisms for the production of intermediates and final products

Abstract

The present disclosure relates to a non-naturally occurring microorganism that includes an endogenous genetic deletion that eliminates the expression of at least a pyruvate kinase, where the genetically modified prokaryotic microorganism is capable of producing 3-deoxy-D-arabino-heptulosonate-7-phosphate.

Inventors:
; ; ; ; ; ; ; ; ; ;
Issue Date:
Research Org.:
National Renewable Energy Laboratory (NREL), Golden, CO (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1986892
Patent Number(s):
11518975
Application Number:
16/399,597
Assignee:
Alliance for Sustainable Energy, LLC (Golden, CO); UT-Battelle LLC (Oak Ridge, TN); Triad National Security, LLC (Los Alamos, NM)
DOE Contract Number:  
AC36-08GO28308
Resource Type:
Patent
Resource Relation:
Patent File Date: 04/30/2019
Country of Publication:
United States
Language:
English

Citation Formats

Johnson, Christopher W., St. John, Peter Corbin, Beckham, Gregg Tyler, Elmore, Joshua Ryan, Guss, Adam Michael, Rodriguez, Davinia Salvachua, Bentley, Gayle Joann, Peabody, V., George Lee, Dale, Taraka, Jha, Ramesh K., and Narayanan, Niju. Engineered microorganisms for the production of intermediates and final products. United States: N. p., 2022. Web.
Johnson, Christopher W., St. John, Peter Corbin, Beckham, Gregg Tyler, Elmore, Joshua Ryan, Guss, Adam Michael, Rodriguez, Davinia Salvachua, Bentley, Gayle Joann, Peabody, V., George Lee, Dale, Taraka, Jha, Ramesh K., & Narayanan, Niju. Engineered microorganisms for the production of intermediates and final products. United States.
Johnson, Christopher W., St. John, Peter Corbin, Beckham, Gregg Tyler, Elmore, Joshua Ryan, Guss, Adam Michael, Rodriguez, Davinia Salvachua, Bentley, Gayle Joann, Peabody, V., George Lee, Dale, Taraka, Jha, Ramesh K., and Narayanan, Niju. Tue . "Engineered microorganisms for the production of intermediates and final products". United States. https://www.osti.gov/servlets/purl/1986892.
@article{osti_1986892,
title = {Engineered microorganisms for the production of intermediates and final products},
author = {Johnson, Christopher W. and St. John, Peter Corbin and Beckham, Gregg Tyler and Elmore, Joshua Ryan and Guss, Adam Michael and Rodriguez, Davinia Salvachua and Bentley, Gayle Joann and Peabody, V., George Lee and Dale, Taraka and Jha, Ramesh K. and Narayanan, Niju},
abstractNote = {The present disclosure relates to a non-naturally occurring microorganism that includes an endogenous genetic deletion that eliminates the expression of at least a pyruvate kinase, where the genetically modified prokaryotic microorganism is capable of producing 3-deoxy-D-arabino-heptulosonate-7-phosphate.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2022},
month = {12}
}

Works referenced in this record:

Production of Monatin and Monatin Precursors
patent-application, October 2005


Improved Production of Medium-Chain-Length Polyhydroxyalkanoates in Glucose-Based Fed-Batch Cultivations of Metabolically Engineered Pseudomonas putida Strains
journal, January 2014


Mutational analysis of the feedback sites of phenylalanine-sensitive 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase of Escherichia coli
journal, February 1997


Muconic Acid Production via Alternative Pathways and a Synthetic “Metabolic Funnel”
journal, November 2017