Engineered microorganisms for the production of intermediates and final products
Abstract
The present disclosure relates to a non-naturally occurring microorganism that includes an endogenous genetic deletion that eliminates the expression of at least a pyruvate kinase, where the genetically modified prokaryotic microorganism is capable of producing 3-deoxy-D-arabino-heptulosonate-7-phosphate.
- Inventors:
- Issue Date:
- Research Org.:
- National Renewable Energy Laboratory (NREL), Golden, CO (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1986892
- Patent Number(s):
- 11518975
- Application Number:
- 16/399,597
- Assignee:
- Alliance for Sustainable Energy, LLC (Golden, CO); UT-Battelle LLC (Oak Ridge, TN); Triad National Security, LLC (Los Alamos, NM)
- DOE Contract Number:
- AC36-08GO28308
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 04/30/2019
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Johnson, Christopher W., St. John, Peter Corbin, Beckham, Gregg Tyler, Elmore, Joshua Ryan, Guss, Adam Michael, Rodriguez, Davinia Salvachua, Bentley, Gayle Joann, Peabody, V., George Lee, Dale, Taraka, Jha, Ramesh K., and Narayanan, Niju. Engineered microorganisms for the production of intermediates and final products. United States: N. p., 2022.
Web.
Johnson, Christopher W., St. John, Peter Corbin, Beckham, Gregg Tyler, Elmore, Joshua Ryan, Guss, Adam Michael, Rodriguez, Davinia Salvachua, Bentley, Gayle Joann, Peabody, V., George Lee, Dale, Taraka, Jha, Ramesh K., & Narayanan, Niju. Engineered microorganisms for the production of intermediates and final products. United States.
Johnson, Christopher W., St. John, Peter Corbin, Beckham, Gregg Tyler, Elmore, Joshua Ryan, Guss, Adam Michael, Rodriguez, Davinia Salvachua, Bentley, Gayle Joann, Peabody, V., George Lee, Dale, Taraka, Jha, Ramesh K., and Narayanan, Niju. Tue .
"Engineered microorganisms for the production of intermediates and final products". United States. https://www.osti.gov/servlets/purl/1986892.
@article{osti_1986892,
title = {Engineered microorganisms for the production of intermediates and final products},
author = {Johnson, Christopher W. and St. John, Peter Corbin and Beckham, Gregg Tyler and Elmore, Joshua Ryan and Guss, Adam Michael and Rodriguez, Davinia Salvachua and Bentley, Gayle Joann and Peabody, V., George Lee and Dale, Taraka and Jha, Ramesh K. and Narayanan, Niju},
abstractNote = {The present disclosure relates to a non-naturally occurring microorganism that includes an endogenous genetic deletion that eliminates the expression of at least a pyruvate kinase, where the genetically modified prokaryotic microorganism is capable of producing 3-deoxy-D-arabino-heptulosonate-7-phosphate.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2022},
month = {12}
}
Works referenced in this record:
Production of Monatin and Monatin Precursors
patent-application, October 2005
- McFarlan, Sara C.; Hicks, Paula M.; Zidwick, Mary Jo
- US Patent Application 10/969245; 20050221455
Pseudomonas putida KT2440 Strain Metabolizes Glucose through a Cycle Formed by Enzymes of the Entner-Doudoroff, Embden-Meyerhof-Parnas, and Pentose Phosphate Pathways
journal, September 2015
- Nikel, Pablo I.; Chavarría, Max; Fuhrer, Tobias
- Journal of Biological Chemistry, Vol. 290, Issue 43
Improved Production of Medium-Chain-Length Polyhydroxyalkanoates in Glucose-Based Fed-Batch Cultivations of Metabolically Engineered Pseudomonas putida Strains
journal, January 2014
- Poblete-Castro, Ignacio; Rodriguez, Andre Luis; Lam, Carolyn Ming Chi
- Journal of Microbiology and Biotechnology, Vol. 24, Issue 1
Method for analyzing and synthesizing functional polypeptide sequences for assembly into enhanced or multi-functional proteins
patent, August 1990
- Jasin, Maria; Schimmel, Paul
- US Patent Document 4,952,501
Mutational analysis of the feedback sites of phenylalanine-sensitive 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase of Escherichia coli
journal, February 1997
- Kikuchi, Y.; Tsujimoto, K.; Kurahashi, O.
- Applied and Environmental Microbiology, Vol. 63, Issue 2
Muconic Acid Production via Alternative Pathways and a Synthetic “Metabolic Funnel”
journal, November 2017
- Thompson, Brian; Pugh, Shawn; Machas, Michael
- ACS Synthetic Biology, Vol. 7, Issue 2