Multi-channel pulsed valve inlet system and method
Abstract
A multichannel inlet system for a mass spectrometer includes a plurality of valve assemblies coupled to a manifold, and a pulsed valve driver. The manifold is configured to be connected in fluid connection with an ion trap of the mass spectrometer. Each valve assembly includes a valve and an injection port operably coupled to receive the reagent. The valve has an actuated state in which the valve provides fluid communication between the injection port and the manifold, and an unactuated state in which the valve substantially prevents fluid communication between the injection port and the manifold. The pulsed valve driver is operably connected to receive a pulse signal sequence from a processor, and is configured to generate pulsed valve drive signals for one or more of the valves based on the pulse signal sequence to cause a corresponding one of the valves to be in the actuated state.
- Inventors:
- Issue Date:
- Research Org.:
- Purdue Univ., West Lafayette, IN (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1986693
- Patent Number(s):
- 11469092
- Application Number:
- 16/855,625
- Assignee:
- Purdue Research Foundation (West Lafayette, IN)
- DOE Contract Number:
- SC0000997
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 04/22/2020
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Kenttamaa, Hilkka, Hilger, Ryan, Yerabolu, Ravikiran, Kong, John, Prentice, Tiffany, and Jin, Chunfen. Multi-channel pulsed valve inlet system and method. United States: N. p., 2022.
Web.
Kenttamaa, Hilkka, Hilger, Ryan, Yerabolu, Ravikiran, Kong, John, Prentice, Tiffany, & Jin, Chunfen. Multi-channel pulsed valve inlet system and method. United States.
Kenttamaa, Hilkka, Hilger, Ryan, Yerabolu, Ravikiran, Kong, John, Prentice, Tiffany, and Jin, Chunfen. Tue .
"Multi-channel pulsed valve inlet system and method". United States. https://www.osti.gov/servlets/purl/1986693.
@article{osti_1986693,
title = {Multi-channel pulsed valve inlet system and method},
author = {Kenttamaa, Hilkka and Hilger, Ryan and Yerabolu, Ravikiran and Kong, John and Prentice, Tiffany and Jin, Chunfen},
abstractNote = {A multichannel inlet system for a mass spectrometer includes a plurality of valve assemblies coupled to a manifold, and a pulsed valve driver. The manifold is configured to be connected in fluid connection with an ion trap of the mass spectrometer. Each valve assembly includes a valve and an injection port operably coupled to receive the reagent. The valve has an actuated state in which the valve provides fluid communication between the injection port and the manifold, and an unactuated state in which the valve substantially prevents fluid communication between the injection port and the manifold. The pulsed valve driver is operably connected to receive a pulse signal sequence from a processor, and is configured to generate pulsed valve drive signals for one or more of the valves based on the pulse signal sequence to cause a corresponding one of the valves to be in the actuated state.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2022},
month = {10}
}
Works referenced in this record:
Identification of Epoxide Functionalities in Protonated Monofunctional Analytes by Using Ion/Molecule Reactions and Collision-Activated Dissociation in Different Ion Trap Tandem Mass Spectrometers
journal, October 2011
- Eismin, Ryan J.; Fu, Mingkun; Yem, Sonoeun
- Journal of The American Society for Mass Spectrometry, Vol. 23, Issue 1
Estimation of effective ion temperatures in a quadrupole ion trap
journal, August 1998
- Gronert, Scott
- Journal of the American Society for Mass Spectrometry, Vol. 9, Issue 8
Multiple sample introduction mass spectrometry
patent, March 2001
- Andrien, Jr., Bruce A.; Whitehouse, Craig M.; Shen, Shida
- US Patent Document 6,207,954
Identification of the sulfoxide functionality in protonated analytes via ion/molecule reactions in linear quadrupole ion trap mass spectrometry
journal, January 2014
- Sheng, Huaming; Williams, Peggy E.; Tang, Weijuan
- The Analyst, Vol. 139, Issue 17
Atmospheric pressure ion source for mass spectrometry
patent, December 2011
- Whitehouse, Craig M.; White, Thomas; Willoughby, Ross C.
- US Patent Document 8,080,783
Internal pulsed valve sample introduction on a quadrupole ion trap mass spectrometer
journal, October 1995
- Coopersmith, Brad I.; Yost, Richard A.
- Journal of the American Society for Mass Spectrometry, Vol. 6, Issue 10
Comparison of Functional Group Selective Ion–Molecule Reactions of Trimethyl Borate in Different Ion Trap Mass Spectrometers
journal, February 2011
- Habicht, Steve C.; Vinueza, Nelson R.; Amundson, Lucas M.
- Journal of The American Society for Mass Spectrometry, Vol. 22, Issue 3
Principles of collisional activation in analytical mass spectrometry
journal, September 1992
- McLuckey, Scott A.
- Journal of the American Society for Mass Spectrometry, Vol. 3, Issue 6
Method for Cooling Ions in a Linear Ion Trap
patent-application, July 2011
- Collings, Bruce
- US Patent Application 12/359563; 20110174965
Multiple electrospray probe interface for mass spectrometry
patent, October 2008
- Bailey, Thomas H.; Tappan, James E.
- US Patent Document 7,439,499
Mass spectrometer with a plurality of ionization probes
patent, December 2002
- Mylchreest, Iain C.; Hemenway, Tina A.; Hartford, Richard E.
- US Patent Document 6,501,073
Sample introduction device for mass spectrometry using a fast fluidic system to synchronize multiple parallel liquid sample streams
patent, January 2005
- Weiss, Adam
- US Patent Document 6,841,774
Ozone-Induced Dissociation on a Modified Tandem Linear Ion-Trap: Observations of Different Reactivity for Isomeric Lipids
journal, December 2010
- Poad, Berwyck L. J.; Pham, Huong T.; Thomas, Michael C.
- Journal of the American Society for Mass Spectrometry, Vol. 21, Issue 12
Methods for Fragmenting Ions in a Linear Ion Trap
patent-application, August 2009
- Guna, Mircea; Collings, Bruce
- US Patent Application 12/359621; 20090194686
Method of Operating a Linear Ion Trap to Provide Low Pressure Short Time High Amplitude Excitation with Pulsed Pressure
patent-application, August 2009
- Guna, Mircea; Le Blanc, Yves; Collings, Bruce
- US Patent Application 12/359526; 20090194684
Sensitive Glow Discharge Ion Source for Aerosol and Gas Analysis
patent-application, February 2007
- Reilly, Peter T. A.
- US Patent Application 11/172330; 20070023679
Parallel fluid electrospray mass spectrometer
patent, May 2000
- Kassel, Daniel B.; Wang, Tao; Zeng, Lu
- US Patent Document 6,066,848
Investigation of the gas phase reactivity of the 1-adamantyl radical using a distonic radical anion approach
journal, January 2007
- Harman, David G.; Blanksby, Stephen J.
- Organic & Biomolecular Chemistry, Vol. 5, Issue 21
Methods and apparatus for the ion mobility based separation and collection of molecules
patent, February 2016
- Wu, Ching
- US Patent Document 9,257,269
Functional Group Selective Ion/Molecule Reactions: Mass Spectrometric Identification of the Amido Functionality in Protonated Monofunctional Compounds
journal, April 2007
- Campbell, Karinna M.; Watkins, Michael A.; Li, Sen
- The Journal of Organic Chemistry, Vol. 72, Issue 9
Pulsed gas introduction into quadrupole ion traps
journal, July 1990
- Emary, W. Bart; Kaiser, Raymond E.; Kenttämaa, Hilkka I.
- Journal of the American Society for Mass Spectrometry, Vol. 1, Issue 4
Information on the location of carbon-carbon double bonds in C6−C23 linear alkenes from carbon addition reactions in a quadrupole ion trap equipped with a pulsed sample-inlet system
journal, August 1991
- Einhorn, J.; Kenttämaa, H. I.; Cooks, R. G.
- Journal of the American Society for Mass Spectrometry, Vol. 2, Issue 4
Method and apparatus for multiple electrospray sample introduction
patent, February 2004
- Valaskovic, Gary A.
- US Patent Document 6,690,006
Cryogenic 2D Linear Ion Trap and Uses Thereof
patent-application, November 2018
- Polfer, Nicolas Camille; Prox, Todd A.; Tesler, Larry F.
- US Patent Application 15/970348; 20180323051
A two-dimensional quadrupole ion trap mass spectrometer
journal, June 2002
- Schwartz, Jae C.; Senko, Michael W.; Syka, John E. P.
- Journal of the American Society for Mass Spectrometry, Vol. 13, Issue 6