Evolution of tRNA synthetases
Abstract
The disclosure provides amino acid sequence variants of orthogonal aminoacyl-tRNA synthetases (AARSs) having increased activity and selectivity compared to previous AARSs, and methods of producing the same.
- Inventors:
- Issue Date:
- Research Org.:
- Harvard Univ., Cambridge, MA (United States)
- Sponsoring Org.:
- USDOE; National Institutes of Health (NIH); Defense Advanced Research Projects Agency (DARPA)
- OSTI Identifier:
- 1925120
- Patent Number(s):
- 11447809
- Application Number:
- 16/628,456
- Assignee:
- President and Fellows of Harvard College (Cambridge, MA)
- DOE Contract Number:
- AI119813; EB022376; FG02-98ER2031; GM022854; GM106621; GM118062; N66001-12-C-4207
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 07/03/2018
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Liu, David R., and Bryson, Jr., David Irby. Evolution of tRNA synthetases. United States: N. p., 2022.
Web.
Liu, David R., & Bryson, Jr., David Irby. Evolution of tRNA synthetases. United States.
Liu, David R., and Bryson, Jr., David Irby. Tue .
"Evolution of tRNA synthetases". United States. https://www.osti.gov/servlets/purl/1925120.
@article{osti_1925120,
title = {Evolution of tRNA synthetases},
author = {Liu, David R. and Bryson, Jr., David Irby},
abstractNote = {The disclosure provides amino acid sequence variants of orthogonal aminoacyl-tRNA synthetases (AARSs) having increased activity and selectivity compared to previous AARSs, and methods of producing the same.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2022},
month = {9}
}
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