Title: Transcription activator-like effectors

Abstract

Provided herein are compositions, kits and methods useful in the construction of designer transcription activator-like effector (dTALE) polypeptides.

Inventors:

Zhang, Feng; Cong, Le; Kosuri, Sriram; Church, George M.

Issue Date:

2022-09-06

Research Org.:

Harvard Univ., Cambridge, MA (United States)

Sponsoring Org.:

USDOE; National Institutes of Health (NIH); National Science Foundation (NSF); Defense Advanced Research Projects Agency (DARPA)

OSTI Identifier:

1925052

Patent Number(s):

11434262

Application Number:

15/334,341

Assignee:

President and Fellows of Harvard College (Cambridge, MA)

Patent Classifications (CPCs):

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES

C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {

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C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES

C07K14/195 - from bacteria
C07K14/4705 - {stimulating, promoting or activating activity}
C07K2319/00 - Fusion polypeptide
C07K2319/09 - containing a nuclear localisation signal
C07K2319/60 - containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]
C07K2319/80 - containing a DNA binding domain, e.g. Lacl or Tet-repressor

C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {

C12P19/34 - Polynucleotides, e.g. nucleic acids, oligoribonucleotides

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DOE Contract Number:  

EEC-0540879; FG02-02ER63445; HG003170; HG005550; NS073124; W911NF-08-1-0254

Resource Type:

Patent

Resource Relation:

Patent File Date: 10/26/2016

Country of Publication:

United States

Language:

English

Subject:

59 BASIC BIOLOGICAL SCIENCES