Rapid isolation of cyclotron-produced gallium-68
Abstract
Methods for rapid isolation of radionuclides (e.g., 68Ga) produced using a cyclotron and methods for recycling of the parent isotope (e.g., 68Zn) are disclosed. In one version of the method, a solution including a radionuclide (e.g., 68Ga) is created from a target including cations (e.g., 68Zn). The solution including the radionuclide is passed through a first column including a sorbent comprising a hydroxamate resin to adsorb the radionuclide on the sorbent, and the radionuclide is eluted off the sorbent. The cations (e.g., 68Zn) are recovered from a recovery solution that has passed through the first column by passing the recovery solution through a second column including a second sorbent comprising a cation exchange resin.
- Inventors:
- Issue Date:
- Research Org.:
- Mayo Clinic, Rochester, MN (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1924999
- Patent Number(s):
- 11417439
- Application Number:
- 16/328,171
- Assignee:
- Mayo Foundation for Medical Education and Research (Rochester, MN)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
C - CHEMISTRY C01 - INORGANIC CHEMISTRY C01G - COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
- DOE Contract Number:
- SC0008947
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 08/28/2017
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 62 RADIOLOGY AND NUCLEAR MEDICINE
Citation Formats
Pandey, Mukesh K., and DeGrado, Timothy R. Rapid isolation of cyclotron-produced gallium-68. United States: N. p., 2022.
Web.
Pandey, Mukesh K., & DeGrado, Timothy R. Rapid isolation of cyclotron-produced gallium-68. United States.
Pandey, Mukesh K., and DeGrado, Timothy R. Tue .
"Rapid isolation of cyclotron-produced gallium-68". United States. https://www.osti.gov/servlets/purl/1924999.
@article{osti_1924999,
title = {Rapid isolation of cyclotron-produced gallium-68},
author = {Pandey, Mukesh K. and DeGrado, Timothy R.},
abstractNote = {Methods for rapid isolation of radionuclides (e.g., 68Ga) produced using a cyclotron and methods for recycling of the parent isotope (e.g., 68Zn) are disclosed. In one version of the method, a solution including a radionuclide (e.g., 68Ga) is created from a target including cations (e.g., 68Zn). The solution including the radionuclide is passed through a first column including a sorbent comprising a hydroxamate resin to adsorb the radionuclide on the sorbent, and the radionuclide is eluted off the sorbent. The cations (e.g., 68Zn) are recovered from a recovery solution that has passed through the first column by passing the recovery solution through a second column including a second sorbent comprising a cation exchange resin.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2022},
month = {8}
}
Works referenced in this record:
Determination of 68Ga production parameters by different reactions using ALICE and TALYS codes
journal, February 2009
- Sadeghi, Mahdi; Kakavand, Tayeb; Mokhtari, Leila
- Pramana, Vol. 72, Issue 2
Standardized methods for the production of high specific-activity zirconium-89
journal, October 2009
- Holland, Jason P.; Sheh, Yiauchung; Lewis, Jason S.
- Nuclear Medicine and Biology, Vol. 36, Issue 7
Normal Uptake of 68Ga-DOTA-TOC by the Pancreas Uncinate Process Mimicking Malignancy at Somatostatin Receptor PET
journal, April 2012
- Jacobsson, Hans; Larsson, Patricia; Jonsson, Cathrine
- Clinical Nuclear Medicine, Vol. 37, Issue 4
Very high specific activity 66/68Ga from zinc targets for PET
journal, August 2012
- Engle, J. W.; Lopez-Rodriguez, V.; Gaspar-Carcamo, R. E.
- Applied Radiation and Isotopes, Vol. 70, Issue 8
Prospective of 68 Ga-Radiopharmaceutical Development
journal, January 2014
- Velikyan, Irina
- Theranostics, Vol. 4, Issue 1
Solution target for cyclotron production of radiometals
patent-application, August 2017
- DeGrado, Timothy R.; Pandey, Mukesh K.
- US Patent Application 15/311052; 20170221594
Gallium-68 purification
patent-application, March 2013
- Le, Van So
- US Patent Application 13/582200; 20130055855
Gallium-68 somatostatin receptor PET/CT: Is it time to replace 111Indium DTPA octreotide for patients with neuroendocrine tumors?
journal, May 2012
- Öberg, Kjell
- Endocrine, Vol. 42, Issue 1
Generator Breakthrough and Radionuclidic Purification in Automated Synthesis of 68Ga-DOTANOC
journal, June 2013
- Belosi, Francesca; Cicoria, Gianfranco; Lodi, Filippo
- Current Radiopharmaceuticals, Vol. 6, Issue 2
High management impact of Ga-68 DOTATATE (GaTate) PET/CT for imaging neuroendocrine and other somatostatin expressing tumours: Management impact of GaTate PET/CT
journal, February 2012
- Hofman, Michael S.; Kong, Grace; Neels, Oliver C.
- Journal of Medical Imaging and Radiation Oncology, Vol. 56, Issue 1
Improved production and processing of 89Zr using a solution target
journal, January 2016
- Pandey, Mukesh K.; Bansal, Aditya; Engelbrecht, Hendrik P.
- Nuclear Medicine and Biology, Vol. 43, Issue 1
Current status and future needs for standards of radionuclides used in positron emission tomography
journal, June 2013
- Zimmerman, B. E.
- Applied Radiation and Isotopes, Vol. 76
Method of obtaining gallium-68 and use thereof and device for carrying out said method
patent-application, February 2007
- Velikyan, Irina; Langstrom, Bengt; Beyer, Gerd J.
- US Patent Application 10/552206; 20070031329
THERANOSTICS: From Molecular Imaging Using Ga-68 Labeled Tracers and PET/CT to Personalized Radionuclide Therapy - The Bad Berka Experience
journal, January 2012
- Baum, Richard P.; Kulkarni, Harshad R.
- Theranostics, Vol. 2, Issue 5
Cost comparison of 111In-DTPA-octreotide scintigraphy and 68Ga-DOTATOC PET/CT for staging enteropancreatic neuroendocrine tumours
journal, September 2011
- Schreiter, Nils F.; Brenner, Winfried; Nogami, Munenobu
- European Journal of Nuclear Medicine and Molecular Imaging, Vol. 39, Issue 1
The untapped potential of Gallium 68-PET: The next wave of 68Ga-agents
journal, June 2013
- Smith, Daniel L.; Breeman, Wouter A. P.; Sims-Mourtada, Jennifer
- Applied Radiation and Isotopes, Vol. 76
Clinical applications of Gallium-68
journal, June 2013
- Banerjee, Sangeeta Ray; Pomper, Martin G.
- Applied Radiation and Isotopes, Vol. 76
Past, present and future of 68Ge/68Ga generators
journal, June 2013
- Rösch, F.
- Applied Radiation and Isotopes, Vol. 76