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Title: Rapid isolation of cyclotron-produced gallium-68

Abstract

Methods for rapid isolation of radionuclides (e.g., 68Ga) produced using a cyclotron and methods for recycling of the parent isotope (e.g., 68Zn) are disclosed. In one version of the method, a solution including a radionuclide (e.g., 68Ga) is created from a target including cations (e.g., 68Zn). The solution including the radionuclide is passed through a first column including a sorbent comprising a hydroxamate resin to adsorb the radionuclide on the sorbent, and the radionuclide is eluted off the sorbent. The cations (e.g., 68Zn) are recovered from a recovery solution that has passed through the first column by passing the recovery solution through a second column including a second sorbent comprising a cation exchange resin.

Inventors:
;
Issue Date:
Research Org.:
Mayo Clinic, Rochester, MN (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1924999
Patent Number(s):
11417439
Application Number:
16/328,171
Assignee:
Mayo Foundation for Medical Education and Research (Rochester, MN)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
C - CHEMISTRY C01 - INORGANIC CHEMISTRY C01G - COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
DOE Contract Number:  
SC0008947
Resource Type:
Patent
Resource Relation:
Patent File Date: 08/28/2017
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE

Citation Formats

Pandey, Mukesh K., and DeGrado, Timothy R. Rapid isolation of cyclotron-produced gallium-68. United States: N. p., 2022. Web.
Pandey, Mukesh K., & DeGrado, Timothy R. Rapid isolation of cyclotron-produced gallium-68. United States.
Pandey, Mukesh K., and DeGrado, Timothy R. Tue . "Rapid isolation of cyclotron-produced gallium-68". United States. https://www.osti.gov/servlets/purl/1924999.
@article{osti_1924999,
title = {Rapid isolation of cyclotron-produced gallium-68},
author = {Pandey, Mukesh K. and DeGrado, Timothy R.},
abstractNote = {Methods for rapid isolation of radionuclides (e.g., 68Ga) produced using a cyclotron and methods for recycling of the parent isotope (e.g., 68Zn) are disclosed. In one version of the method, a solution including a radionuclide (e.g., 68Ga) is created from a target including cations (e.g., 68Zn). The solution including the radionuclide is passed through a first column including a sorbent comprising a hydroxamate resin to adsorb the radionuclide on the sorbent, and the radionuclide is eluted off the sorbent. The cations (e.g., 68Zn) are recovered from a recovery solution that has passed through the first column by passing the recovery solution through a second column including a second sorbent comprising a cation exchange resin.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2022},
month = {8}
}

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