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Title: CasZ compositions and methods of use

Abstract

Provided are compositions and methods that include one or more of: (1) a “CasZ” protein (also referred to as a CasZ polypeptide), a nucleic acid encoding the CasZ protein, and/or a modified host cell comprising the CasZ protein (and/or a nucleic acid encoding the same); (2) a CasZ guide RNA that binds to and provides sequence specificity to the CasZ protein, a nucleic acid encoding the CasZ guide RNA, and/or a modified host cell comprising the CasZ guide RNA (and/or a nucleic acid encoding the same); and (3) a CasZ transactivating noncoding RNA (trancRNA) (referred to herein as a “CasZ trancRNA”), a nucleic acid encoding the CasZ trancRNA, and/or a modified host cell comprising the CasZ trancRNA (and/or a nucleic acid encoding the same).

Inventors:
; ; ; ; ;
Issue Date:
Research Org.:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE; National Science Foundation (NSF)
OSTI Identifier:
1893076
Patent Number(s):
11371031
Application Number:
17/032,521
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Classifications (CPCs):
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
DOE Contract Number:  
1244557; AC02-05CH11231
Resource Type:
Patent
Resource Relation:
Patent File Date: 09/25/2020
Country of Publication:
United States
Language:
English

Citation Formats

Doudna, Jennifer A., Burstein, David, Chen, Janice Sha, Harrington, Lucas Benjamin, Paez-Espino, David, and Banfield, Jillian F. CasZ compositions and methods of use. United States: N. p., 2022. Web.
Doudna, Jennifer A., Burstein, David, Chen, Janice Sha, Harrington, Lucas Benjamin, Paez-Espino, David, & Banfield, Jillian F. CasZ compositions and methods of use. United States.
Doudna, Jennifer A., Burstein, David, Chen, Janice Sha, Harrington, Lucas Benjamin, Paez-Espino, David, and Banfield, Jillian F. Tue . "CasZ compositions and methods of use". United States. https://www.osti.gov/servlets/purl/1893076.
@article{osti_1893076,
title = {CasZ compositions and methods of use},
author = {Doudna, Jennifer A. and Burstein, David and Chen, Janice Sha and Harrington, Lucas Benjamin and Paez-Espino, David and Banfield, Jillian F.},
abstractNote = {Provided are compositions and methods that include one or more of: (1) a “CasZ” protein (also referred to as a CasZ polypeptide), a nucleic acid encoding the CasZ protein, and/or a modified host cell comprising the CasZ protein (and/or a nucleic acid encoding the same); (2) a CasZ guide RNA that binds to and provides sequence specificity to the CasZ protein, a nucleic acid encoding the CasZ guide RNA, and/or a modified host cell comprising the CasZ guide RNA (and/or a nucleic acid encoding the same); and (3) a CasZ transactivating noncoding RNA (trancRNA) (referred to herein as a “CasZ trancRNA”), a nucleic acid encoding the CasZ trancRNA, and/or a modified host cell comprising the CasZ trancRNA (and/or a nucleic acid encoding the same).},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2022},
month = {6}
}

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