Title: Mutant microorganisms and methods of making and using

Abstract

This disclosure describes methods that allow for the uncoupling of microbial growth from product formation, which allows for maximal use of raw material and optimal end-product formation.

Inventors:

Singh, Raghuveer; White, Derrick; Blum, Paul

Issue Date:

2022-05-17

Research Org.:

Univ. of Nebraska, Lincoln, NE (United States)

Sponsoring Org.:

USDOE

OSTI Identifier:

1892931

Patent Number(s):

11332763

Application Number:

15/568,347

Assignee:

NUtech Ventures (Lincoln, NE)

Patent Classifications (CPCs):

C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES

C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {

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C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES

C12N1/36 - Adaptation or attenuation of cells
C12N9/0006 - {acting on CH-OH groups as donors
C12N9/1217 - {Phosphotransferases with a carboxyl group as acceptor
C12N9/88 - Lyases

C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {

C12P3/00 - Preparation of elements or inorganic compounds except carbon dioxide {
C12P7/065 - {with microorganisms other than yeasts}
C12P7/44 - Polycarboxylic acids
C12P7/54 - Acetic acid

C - CHEMISTRY C12 - BIOCHEMISTRY C12Y - ENZYMES

C12Y101/01027 - L-Lactate dehydrogenase
C12Y207/02001 - Acetate kinase
C12Y401/0103 - Pantothenoylcysteine decarboxylase
C12Y401/01039 - Ribulose-bisphosphate carboxylase

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y02 - TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE Y02E - REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION

Y02E50/10 - Biofuels

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DOE Contract Number:  

PS02-08ER0812; FG02-08ER64687

Resource Type:

Patent

Resource Relation:

Patent File Date: 04/21/2016

Country of Publication:

United States

Language:

English