Methods and systems for producing nanolipoprotein particles
Abstract
Provided herein are methods and systems for the production of a nanolipoprotein particle (NLP) that includes a scaffold protein a membrane forming lipid and optionally a target protein. At least one of the scaffold protein and target protein can be provided through an IVT system. The membrane forming lipid, scaffold protein and optionally the target protein can be assembled for a time and under conditions that allow obtaining high yield NLPs, NPLs with an increased solubility, an NLP of a controlled size, and/or an NLP having a size predetermined to include a pre-selected target protein.
- Inventors:
- Issue Date:
- Research Org.:
- Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1892822
- Patent Number(s):
- 11300572
- Application Number:
- 16/159,189
- Assignee:
- Lawrence Livermore National Security, LLC (Livermore, CA)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {
- DOE Contract Number:
- AC52-07NA27344
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 10/12/2018
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Coleman, Matthew A., Hoeprich, Jr., Paul D., and Segelke, Brent W. Methods and systems for producing nanolipoprotein particles. United States: N. p., 2022.
Web.
Coleman, Matthew A., Hoeprich, Jr., Paul D., & Segelke, Brent W. Methods and systems for producing nanolipoprotein particles. United States.
Coleman, Matthew A., Hoeprich, Jr., Paul D., and Segelke, Brent W. Tue .
"Methods and systems for producing nanolipoprotein particles". United States. https://www.osti.gov/servlets/purl/1892822.
@article{osti_1892822,
title = {Methods and systems for producing nanolipoprotein particles},
author = {Coleman, Matthew A. and Hoeprich, Jr., Paul D. and Segelke, Brent W.},
abstractNote = {Provided herein are methods and systems for the production of a nanolipoprotein particle (NLP) that includes a scaffold protein a membrane forming lipid and optionally a target protein. At least one of the scaffold protein and target protein can be provided through an IVT system. The membrane forming lipid, scaffold protein and optionally the target protein can be assembled for a time and under conditions that allow obtaining high yield NLPs, NPLs with an increased solubility, an NLP of a controlled size, and/or an NLP having a size predetermined to include a pre-selected target protein.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2022},
month = {4}
}
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Works referenced in this record:
Nanoparticles for Delivery of Therapeutic Agents Using Ultrasound and Associated Methods
patent-application, June 2010
- Watkin, Kenneth L.
- US Patent Application 12/694891; 20100158994
Lipopeptaibols, a novel family of membrane active, antimicrobial peptides
journal, August 2001
- Toniolo, C.; Crisma, M.; Formaggio, F.
- Cellular and Molecular Life Sciences, Vol. 58, Issue 9
Studies of synthetic peptide analogs of the amphipathic helix. Correlation of structure with function.
journal, August 1985
- Chung, B. H.; Anatharamaiah, G. M.; Brouillette, C. G.
- Journal of Biological Chemistry, Vol. 260, Issue 18
Methods for Delivering Bioactive Agents
patent-application, December 2001
- Unger, Evan C.
- US Patent Application 09/413110; 20010051131
A 3-Dimensional Trimeric β-Barrel Model for Chlamydia MOMP Contains Conserved and Novel Elements of Gram-Negative Bacterial Porins
journal, July 2013
- Feher, Victoria A.; Randall, Arlo; Baldi, Pierre
- PLoS ONE, Vol. 8, Issue 7
Apolipoprotein A1 Forms 5/5 and 5/4 Antiparallel Dimers in Human High-density Lipoprotein
journal, May 2019
- He, Yi; Song, Hyun D.; Anantharamaiah, G. M.
- Molecular & Cellular Proteomics, Vol. 18, Issue 5
Lipophilic nucleic acid delivery vehicle and methods of use thereof
patent, September 2012
- Ryan, Robert
- US Patent Document 8,268,796
Increased Immunoaccessibility of MOMP Epitopes in a Vaccine Formulated with Amphipols May Account for the Very Robust Protection Elicited against a Vaginal Challenge with Chlamydia muridarum
journal, April 2014
- Tifrea, Delia F.; Pal, Sukumar; Popot, Jean-Luc
- The Journal of Immunology, Vol. 192, Issue 11
Telodendrimer Nanodiscs Without Apolipoprotein
patent-application, June 2013
- Lam, Kit S.; Luo, Juntao; Lee, Joyce S.
- US Patent Application 13/719766; 20130164369
A novel class of photo-triggerable liposomes containing DPPC:DC8,9PC as vehicles for delivery of doxorubcin to cells
journal, January 2011
- Yavlovich, Amichai; Singh, Alok; Blumenthal, Robert
- Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1808, Issue 1
CD4+ T Cells and Antibody Are Required for Optimal Major Outer Membrane Protein Vaccine-Induced Immunity to Chlamydia muridarum Genital Infection
journal, July 2010
- Farris, C. M.; Morrison, S. G.; Morrison, R. P.
- Infection and Immunity, Vol. 78, Issue 10
Telodendrimer-based nanocarriers for the treatment of ovarian cancer
journal, October 2013
- Xiao, Kai; Suby, Nell; Li, Yuanpei
- Therapeutic Delivery, Vol. 4, Issue 10
Polymerization of unsaturated phospholipids as large unilamellar liposomes at low temperature
journal, January 1992
- Tsuchida, Eishun; Hatashita, Masanori; Makino, Chisato
- Macromolecules, Vol. 25, Issue 1
Conformational effects of chiral α,α-dialkyl amino acids I. C-Terminal tetrapeptides of emerimicin containing α-ethylalanine
journal, December 1988
- Marshall, Garland R.; Clark, John D.; Dunbar, James B.
- International Journal of Peptide and Protein Research, Vol. 32, Issue 6
Biodegradable long-circulating polymeric nanospheres
journal, March 1994
- Gref, R.; Minamitake, Y.; Peracchia, M.
- Science, Vol. 263, Issue 5153
Atomic Force Microscope Spectroscopy Reveals a Hemifusion Intermediate during Soluble N-Ethylmaleimide-Sensitive Factor-Attachment Protein Receptors-Mediated Membrane Fusion
journal, January 2008
- Abdulreda, Midhat H.; Bhalla, Akhil; Chapman, Edwin R.
- Biophysical Journal, Vol. 94, Issue 2
Structure and function of membrane proteins encapsulated in a polymer-bound lipid bilayer
journal, April 2018
- Pollock, Naomi L.; Lee, Sarah C.; Patel, Jaimin H.
- Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1860, Issue 4
Lipid Internal Dynamics Probed in Nanodiscs
journal, June 2017
- Martinez, Denis; Decossas, Marion; Kowal, Julia
- ChemPhysChem, Vol. 18, Issue 19
Self-Assembling Cyclic d , l -α-Peptides as Modulators of Plasma HDL Function. A Supramolecular Approach toward Antiatherosclerotic Agents
journal, June 2017
- Zhao, Yannan; Leman, Luke J.; Search, Debra J.
- ACS Central Science, Vol. 3, Issue 6
Telodendrimer nanodiscs without apolipoprotein
patent, November 2014
- Lam, Kit S.; Luo, Juntao; Lee, Joyce S.
- US Patent Document 8,895,055
Membrane targeting and translocation of bacterial hydrogenases
journal, March 2000
- Wu, Long-Fei; Chanal, Angélique; Rodrigue, Agnès
- Archives of Microbiology, Vol. 173, Issue 5-6
Incorporation of a viral DNA-packaging motor channel in lipid bilayers for real-time, single-molecule sensing of chemicals and double-stranded DNA
journal, January 2013
- Haque, Farzin; Geng, Jia; Montemagno, Carlo
- Nature Protocols, Vol. 8, Issue 2
Effect of phospholipid composition on discoidal HDL formation
journal, May 2013
- Miyazaki, Masakazu; Tajima, Yoko; Ishihama, Yasushi
- Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1828, Issue 5
Endothelin-1 enhances oxidative stress, cell proliferation and reduces apoptosis in human umbilical vein endothelial cells: role of ET B receptor, NADPH oxidase and caveolin-1
journal, June 2005
- Dong, Feng; Zhang, Xiaochun; Wold, Loren E.
- British Journal of Pharmacology, Vol. 145, Issue 3
Double Belt Structure of Discoidal High Density Lipoproteins: Molecular Basis for Size Heterogeneity
journal, November 2004
- Li, Ling; Chen, Jianguo; Mishra, Vinod K.
- Journal of Molecular Biology, Vol. 343, Issue 5
Dopamine tone regulates D1 receptor trafficking and delivery in striatal neurons in dopamine transporter-deficient mice
journal, February 2000
- Dumartin, B.; Jaber, M.; Gonon, F.
- Proceedings of the National Academy of Sciences, Vol. 97, Issue 4, p. 1879-1884
Block liposome and nanotube formation is a general phenomenon of two-component membranes containing multivalent lipids
journal, January 2011
- Zidovska, Alexandra; Ewert, Kai K.; Quispe, Joel
- Soft Matter, Vol. 7, Issue 18
Crystal structure of truncated human apolipoprotein A-I suggests a lipid-bound conformation
journal, November 1997
- Borhani, D. W.; Rogers, D. P.; Engler, J. A.
- Proceedings of the National Academy of Sciences, Vol. 94, Issue 23
Amphipathic helix motif: Classes and properties
journal, January 1990
- Segrest, Jere P.; De Loof, Hans; Dohlman, Jan G.
- Proteins: Structure, Function, and Genetics, Vol. 8, Issue 2
ACTH, α-MSH, and control of cortisol release: cloning, sequencing, and functional expression of the melanocortin-2 and melanocortin-5 receptor in C yprinus carpio
journal, September 2005
- Metz, Juriaan R.; Geven, Edwin J. W.; van den Burg, Erwin H.
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, Vol. 289, Issue 3
Contributions of domain structure and lipid interaction to the functionality of exchangeable human apolipoproteins
journal, July 2004
- Saito, Hiroyuki; Lund-Katz, Sissel; Phillips, Michael C.
- Progress in Lipid Research, Vol. 43, Issue 4
Surface Functionalization of a Polymeric Lipid Bilayer for Coupling a Model Biological Membrane with Molecules, Cells, and Microstructures
journal, February 2013
- Morigaki, Kenichi; Mizutani, Kazuyuki; Saito, Makoto
- Langmuir, Vol. 29, Issue 8
Membrane scaffold proteins and tethered membrane proteins
patent, August 2009
- Sligar, Stephen G.; Bayburt, Timothy H.
- US Patent Document 7,575,763
Comparative EPR studies on lipid bilayer properties in nanodiscs and liposomes
journal, January 2015
- Stepien, Piotr; Polit, Agnieszka; Wisniewska-Becker, Anna
- Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1848, Issue 1
Polymerization of liposomes composed of diene-containing lipids by UV and radical initiators: evidence for the different chemical environment of diene groups on 1- and 2-acyl chains
journal, May 1987
- Ohno, Hiroyuki; Ogata, Yoshitaka; Tsuchida, Eishun
- Macromolecules, Vol. 20, Issue 5
Polymerized surfactant vesicles. Determinations of rates and degrees of polymerization in vesicles prepared from styrene-containing surfactants
journal, October 1985
- Serrano, Juan; Mucino, Sergio; Millan, Sonia
- Macromolecules, Vol. 18, Issue 10
Therapeutic Nanoparticles for Drug Delivery in Cancer
journal, March 2008
- Cho, K.; Wang, X.; Nie, S.
- Clinical Cancer Research, Vol. 14, Issue 5
Characterizing the Membrane-Bound State of Cytochrome P450 3A4: Structure, Depth of Insertion, and Orientation
journal, May 2013
- Baylon, Javier L.; Lenov, Ivan L.; Sligar, Stephen G.
- Journal of the American Chemical Society, Vol. 135, Issue 23
Predicting Fuel Performance for Future HCCI Engines
journal, May 2013
- Rapp, Vi H.; Cannella, William J.; Chen, J. -Y.
- Combustion Science and Technology, Vol. 185, Issue 5
Well-Defined, Size-Tunable, Multifunctional Micelles for Efficient Paclitaxel Delivery for Cancer Treatment
journal, July 2010
- Luo, Juntao; Xiao, Kai; Li, Yuanpei
- Bioconjugate Chemistry, Vol. 21, Issue 7
The Effects of Deleting the Mouse Neurotensin Receptor NTR1 on Central and Peripheral Responses to Neurotensin
journal, January 2002
- Pettibone, Douglas J.; Hess, J. Fred; Hey, Patricia J.
- Journal of Pharmacology and Experimental Therapeutics, Vol. 300, Issue 1
Development status and future prospects for a vaccine against Chlamydia trachomatis infection
journal, March 2014
- Hafner, Louise M.; Wilson, David P.; Timms, Peter
- Vaccine, Vol. 32, Issue 14
Enhanced Protein Thermostability by Ala → Aib Replacement
journal, January 1998
- De Filippis, Vincenzo; De Antoni, Filippo; Frigo, Marta
- Biochemistry, Vol. 37, Issue 6
Cationic lipid nanodisks as an siRNA delivery vehicle
journal, June 2014
- Ghosh, Mistuni; Ren, Gang; Simonsen, Jens B.
- Biochemistry and Cell Biology, Vol. 92, Issue 3
Cell-Free Co-Translational Approaches for Producing Mammalian Receptors: Expanding the Cell-Free Expression Toolbox Using Nanolipoproteins
journal, July 2019
- Shelby, Megan L.; He, Wei; Dang, Amanda T.
- Frontiers in Pharmacology, Vol. 10
Nanostructures Suitable for Sequestering Cholesterol and Other Molecules
patent-application, December 2009
- Mirkin, Chad A.; Thaxton, C. Shad; Giljohann, David A.
- US Patent Application 12/429560; 20090324706
Hydrogenase
journal, December 1980
- Adams, Michael W. W.; Mortenson, Leonard E.; Chen, Jiann-Shin
- Biochimica et Biophysica Acta (BBA) - Reviews on Bioenergetics, Vol. 594, Issue 2-3, p. 105-176
Apolipoprotein nanodiscs with telodendrimer
patent, July 2021
- Luo, Juntao; He, Wei; Lam, Kit S.
- US Patent Document 11,053,322
Fluorescence Study of Inclusion Complexes between Star-Shaped Cholic Acid Derivatives and Polycyclic Aromatic Fluorescent Probes and the Size Effects of Host and Guest Molecules
journal, March 2008
- Chen, Yilong; Luo, Juntao; Zhu, X. X.
- The Journal of Physical Chemistry B, Vol. 112, Issue 11, p. 3402-3409
PEG-oligocholic acid telodendrimer micelles for the targeted delivery of doxorubicin to B-cell lymphoma
journal, October 2011
- Xiao, Kai; Luo, Juntao; Li, Yuanpei
- Journal of Controlled Release, Vol. 155, Issue 2, p. 272-281
Monitoring Shifts in the Conformation Equilibrium of the Membrane Protein Cytochrome P450 Reductase (POR) in Nanodiscs*
journal, October 2012
- Wadsäter, Maria; Laursen, Tomas; Singha, Aparajita
- Journal of Biological Chemistry, Vol. 287, Issue 41
Emerging implications of nanotechnology on cancer diagnostics and therapeutics
journal, January 2006
- Cuenca, Alex G.; Jiang, Huabei; Hochwald, Steven N.
- Cancer, Vol. 107, Issue 3
Single-molecule height measurements on microsomal cytochrome P450 in nanometer-scale phospholipid bilayer disks
journal, May 2002
- Bayburt, T. H.; Sligar, S. G.
- Proceedings of the National Academy of Sciences, Vol. 99, Issue 10, p. 6725-6730
Formulations of paclitaxel, its derivatives or its analogs entrapped into nanoparticles of polymeric micelles, process for preparing same and the use thereof
patent, April 2002
- Burman, Anand C.; Mukherjee, Rama; Khattar, Dhiraj
- US Patent Document 6,365,191
The diversity of FtsY-lipid interactions
journal, February 2010
- Reinau, M. E.; Thøgersen, I. B.; Enghild, J. J.
- Biopolymers, Vol. 93, Issue 7
Delivery of hydrophilic drug doxorubicin hydrochloride-targeted liver using apoAI as carrier
journal, April 2013
- Yuan, Yuan; Wang, Weina; Wang, Baolong
- Journal of Drug Targeting, Vol. 21, Issue 4
A Multi-Component Prime-Boost Vaccination Regimen with a Consensus MOMP Antigen Enhances Chlamydia trachomatis Clearance
journal, April 2016
- Badamchi-Zadeh, Alexander; McKay, Paul F.; Korber, Bette T.
- Frontiers in Immunology, Vol. 7
G-Protein-Coupled Receptor Microarrays for Multiplexed Compound Screening
journal, June 2006
- Hong, Yulong; Webb, Brian L.; Pai, Sadashiva
- Journal of Biomolecular Screening, Vol. 11, Issue 4
Cell-free synthesis and processing of a putative precursor for mitochondrial carbamyl phosphate synthetase I of rat liver
journal, October 1979
- Mori, M.; Miura, S.; Tatibana, M.
- Proceedings of the National Academy of Sciences, Vol. 76, Issue 10
Screening of Type I and II Drug Binding to Human Cytochrome P450-3A4 in Nanodiscs by Localized Surface Plasmon Resonance Spectroscopy
journal, April 2009
- Das, Aditi; Zhao, Jing; Schatz, George C.
- Analytical Chemistry, Vol. 81, Issue 10
A multi-epitope vaccine based on Chlamydia trachomatis major outer membrane protein induces specific immunity in mice
journal, March 2014
- Tu, J.; Hou, B.; Wang, B.
- Acta Biochimica et Biophysica Sinica, Vol. 46, Issue 5
Induction of protection against vaginal shedding and infertility by a recombinant Chlamydia vaccine
journal, July 2011
- Carmichael, Jennifer R.; Pal, Sukumar; Tifrea, Delia
- Vaccine, Vol. 29, Issue 32
Methods and Compositions for Liposomal Formulation of Antigens and Uses Thereof
patent-application, October 2014
- Fujii, Gary; Szoka, Jr., Francis C.; Watson, Douglas S.
- US Patent Application 14/320278; 20140308341
How Translocons Select Transmembrane Helices
journal, June 2008
- White, Stephen H.; von Heijne, Gunnar
- Annual Review of Biophysics, Vol. 37, Issue 1
Different G protein-coupled receptor kinases govern G protein and β-arrestin-mediated signaling of V2 vasopressin receptor
journal, January 2005
- Ren, X.-R.; Reiter, E.; Ahn, S.
- Proceedings of the National Academy of Sciences, Vol. 102, Issue 5, p. 1448-1453
Electrochemical flow-cell for hydrogen production and nicotinamide dependent target reduction, and related methods and systems
patent, December 2018
- Hoeprich, Jr., Paul D.; Kim, Sangil
- US Patent Document 10,151,037
Nanoparticles for delivery of therapeutic agents using ultrasound and associated methods
patent-application, June 2006
- Watkin, Kenneth L.
- US Patent Application 11/271641; 20060127467
Surfactant-like Properties of an Amphiphilic α-Helical Peptide Leading to Lipid Nanodisc Formation
journal, April 2014
- Imura, Tomohiro; Tsukui, Yohei; Taira, Toshiaki
- Langmuir, Vol. 30, Issue 16
Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo
journal, October 2014
- Zuris, John A.; Thompson, David B.; Shu, Yilai
- Nature Biotechnology, Vol. 33, Issue 1
Polymerized liposomes formed under extremely mild conditions
journal, November 1986
- Sadownik, Andrzej.; Stefely, James.; Regen, Steven L.
- Journal of the American Chemical Society, Vol. 108, Issue 24
From Gene to HSQC in under Five Hours: High-Throughput NMR Proteomics
journal, April 2006
- Keppetipola, Shiranthi; Kudlicki, Wieslaw; Nguyen, Bao D.
- Journal of the American Chemical Society, Vol. 128, Issue 14
Intracytoplasmic delivery of anionic proteins
journal, June 2004
- Dalkara, Deniz; Zuber, Guy; Behr, Jean-Paul
- Molecular Therapy, Vol. 9, Issue 6
Characterization of De Novo Synthesized GPCRs Supported in Nanolipoprotein Discs
journal, September 2012
- Gao, Tingjuan; Petrlova, Jitka; He, Wei
- PLoS ONE, Vol. 7, Issue 9
Degree of polymerization of a vesicle membrane
journal, June 1984
- Bolikal, Durgadas; Regen, Steven L.
- Macromolecules, Vol. 17, Issue 6
From Combinatorial Chemistry to Cancer-Targeting Peptides
journal, August 2007
- Aina, Olulanu H.; Liu, Ruiwu; Sutcliffe, Julie L.
- Molecular Pharmaceutics, Vol. 4, Issue 5
A concise review of carbon nanotube's toxicology
journal, January 2013
- Madani, Seyed Yazdan; Mandel, Abraham; Seifalian, Alexander M.
- Nano Reviews, Vol. 4, Issue 1
Colocalized Delivery of Adjuvant and Antigen Using Nanolipoprotein Particles Enhances the Immune Response to Recombinant Antigens
journal, January 2013
- Fischer, Nicholas O.; Rasley, Amy; Corzett, Michele
- Journal of the American Chemical Society, Vol. 135, Issue 6
Apolipoprotein Nanodiscs with Telodendrimer
patent-application, March 2018
- Luo, Junato; He, Wei; Lam, Kit S.
- US Patent Application 15/499855; 20180079829
Liposomal Pharmaceutical Preparation and Method for Manufacturing the Same
patent-application, August 2016
- Li, Chunlei; Wang, Jinxu; Wang, Caixia
- US Patent Application 15/138527; 20160235671
Small molecules from the human microbiota
journal, July 2015
- Donia, M. S.; Fischbach, M. A.
- Science, Vol. 349, Issue 6246
Immobilized Polydiacetylene Vesicles on Solid Substrates for Use as Chemosensors
journal, July 2003
- Kim, J. -M.; Ji, E. -K.; Woo, S. M.
- Advanced Materials, Vol. 15, Issue 13
Tumor targeting effects of a novel modified paclitaxel-loaded discoidal mimic high density lipoproteins
journal, September 2013
- Wang, Ji; Jia, Junting; Liu, Jianping
- Drug Delivery, Vol. 20, Issue 8
Stable Nanolipoprotein Particles and Related Compositions Methods and Systems
patent-application, May 2019
- Blanchette, Craig D.; Fischer, Nicholas; Gilmore, Sean Fitzpatrick
- US Patent Application 15/755018; 20190142752
Water soluble chitosan nanoparticle for delivering an anticancer agent and preparing method thereof
patent-application, January 2006
- Nah, Jae-Woon; Jung, Teok Rae; Jang, Mi-Kyeong
- US Patent Application 11/128297; 20060013885
Effect of cholesterol on the charge and structure of apolipoprotein A-I in recombinant high density lipoprotein particles.
journal, November 1993
- Sparks, D. L.; Davidson, W. S.; Lund-Katz, S.
- Journal of Biological Chemistry, Vol. 268, Issue 31
Equation of State for Phospholipid Self-Assembly
journal, January 2016
- Marsh, Derek
- Biophysical Journal, Vol. 110, Issue 1
A Probiotic Adjuvant Lactobacillus rhamnosus Enhances Specific Immune Responses after Ocular Mucosal Immunization with Chlamydial Polymorphic Membrane Protein C
journal, September 2016
- Inic-Kanada, Aleksandra; Stojanovic, Marijana; Marinkovic, Emilija
- PLOS ONE, Vol. 11, Issue 9
Membrane scaffold proteins and embedded membrane proteins
patent, February 2010
- Sligar, Stephen G.; Bayburt, Timothy H.
- US Patent Document 7,662,410
Corticotropin Releasing Factor (CRF) Receptor Signaling in the Central Nervous System: New Molecular Targets
journal, August 2006
- Hauger, Richard; Risbrough, Victoria; Brauns, Olaf
- CNS & Neurological Disorders - Drug Targets, Vol. 5, Issue 4
Apolipoprotein Nanodiscs with Telodendrimer
patent-application, June 2013
- Luo, Juntao; He, Wei; Lam, Kit S.
- US Patent Application 13/719785; 20130165636
Asymmetric Poly(ethylene glycol) Star Polymers with a Cholic Acid Core and Their Aggregation Properties
journal, April 2009
- Luo, Juntao; Giguère, Guillaume; Zhu, X. X.
- Biomacromolecules, Vol. 10, Issue 4, p. 900-906
Electrochemical Flow-Cell for Hydrogen Production and Nicotinamide Dependent Target Reduction, and Related Methods and Systems
patent-application, March 2016
- Hoeprich, JR., Paul D.; Kim, Sangil
- US Patent Application 14/861750; 20160083858
Tissue factor compositions and methods
patent, November 2009
- Morrissey, James H.; Pureza, Vincent S.; Sligar, Stephen G.
- US Patent Document 7,622,437
Quantifying Interactions of a Membrane Protein Embedded in a Lipid Nanodisc using Fluorescence Correlation Spectroscopy
journal, January 2014
- Ly, Sonny; Bourguet, Feliza; Fischer, Nicholas O.
- Biophysical Journal, Vol. 106, Issue 2
Controlling the diameter, monodispersity, and solubility of ApoA1 nanolipoprotein particles using telodendrimer chemistry: Size and Stability of NLPs
journal, June 2013
- He, Wei; Luo, Juntao; Bourguet, Feliza
- Protein Science, Vol. 22, Issue 8
Characterizing diffusion dynamics of a membrane protein associated with nanolipoproteins using fluorescence correlation spectroscopy
journal, January 2011
- Gao, Tingjuan; Blanchette, Craig D.; He, Wei
- Protein Science, Vol. 20, Issue 2
Small multidrug resistance proteins: A multidrug transporter family that continues to grow
journal, September 2008
- Bay, Denice C.; Rommens, Kenton L.; Turner, Raymond J.
- Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1778, Issue 9
Properties of a Versatile Nanoparticle Platform Contrast Agent To Image and Characterize Atherosclerotic Plaques by Magnetic Resonance Imaging
journal, October 2006
- Frias, Juan C.; Ma, Yanqing; Williams, Kevin Jon
- Nano Letters, Vol. 6, Issue 10
Atomic force microscopy differentiates discrete size distributions between membrane protein containing and empty nanolipoprotein particles
journal, March 2009
- Blanchette, Craig D.; Cappuccio, Jenny A.; Kuhn, Edward A.
- Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1788, Issue 3, p. 724-731
Two-dimensional polymerization of lipid bilayers: degree of polymerization of acryloyl lipids
journal, January 1994
- Sells, Todd D.; O'Brien, David F.
- Macromolecules, Vol. 27, Issue 1
Comparative Preclinical and Clinical Pharmacokinetics of a Cremophor-Free, Nanoparticle Albumin-Bound Paclitaxel (ABI-007) and Paclitaxel Formulated in Cremophor (Taxol)
journal, June 2005
- Sparreboom, Alex; Scripture, Charity D.; Trieu, Vuong
- Clinical Cancer Research, Vol. 11, Issue 11
Two-Dimensional Polymerization of Lipid Bilayers:Degree of Polymerization of Sorbyl Lipids
journal, March 1995
- Lamparski, Henry; O'Brien, David F.
- Macromolecules, Vol. 28, Issue 6
Nanodisks Derived from Amphotericin B Lipid Complex
journal, October 2008
- Tufteland, Megan; Ren, Gang; Ryan, Robert O.
- Journal of Pharmaceutical Sciences, Vol. 97, Issue 10
The unsolved mystery of apoA-I recycling in adipocyte
journal, February 2016
- Wang, Shuai; Peng, Dao-quan; Yi, Yuhong
- Lipids in Health and Disease, Vol. 15, Issue 1
Design and Characterization of Immobilized Enzymes in Microfluidic Systems
journal, December 2001
- Mao, Hanbin; Yang, Tinglu; Cremer, Paul S.
- Analytical Chemistry, Vol. 74, Issue 2
Enhancement of the protective efficacy of a Chlamydia trachomatis recombinant vaccine by combining systemic and mucosal routes for immunization
journal, November 2010
- Ralli-Jain, Pooja; Tifrea, Delia; Cheng, Chunmei
- Vaccine, Vol. 28, Issue 48
Structure of saposin A lipoprotein discs
journal, February 2012
- Popovic, K.; Holyoake, J.; Pomes, R.
- Proceedings of the National Academy of Sciences, Vol. 109, Issue 8
Cell-free expression of functional receptor tyrosine kinases
journal, August 2015
- He, Wei; Scharadin, Tiffany M.; Saldana, Matthew
- Scientific Reports, Vol. 5, Issue 1
Designer vaccine nanodiscs for personalized cancer immunotherapy
journal, December 2016
- Kuai, Rui; Ochyl, Lukasz J.; Bahjat, Keith S.
- Nature Materials, Vol. 16, Issue 4
Isolation, Characterization, and Stability of Discretely-Sized Nanolipoprotein Particles Assembled with Apolipophorin-III
journal, July 2010
- Fischer, Nicholas O.; Blanchette, Craig D.; Segelke, Brent W.
- PLoS ONE, Vol. 5, Issue 7
Investigations of Bivalent Antibody Binding on Fluid-Supported Phospholipid Membranes: The Effect of Hapten Density
journal, March 2003
- Yang, Tinglu; Baryshnikova, Olga K.; Mao, Hanbin
- Journal of the American Chemical Society, Vol. 125, Issue 16
Identification of surface-exposed components of MOMP of Chlamydia trachomatis serovar F
journal, January 2006
- Wang, Y.
- Protein Science, Vol. 15, Issue 1
Supported Lipid Bilayer Formation and Lipid-Membrane-Mediated Biorecognition Reactions Studied with a New Nanoplasmonic Sensor Template
journal, September 2007
- Jonsson, Magnus P.; Jönsson, Peter; Dahlin, Andreas B.
- Nano Letters, Vol. 7, Issue 11
MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins
journal, March 2011
- Vickers, Kasey C.; Palmisano, Brian T.; Shoucri, Bassem M.
- Nature Cell Biology, Vol. 13, Issue 4
Nanodiscs in Membrane Biochemistry and Biophysics
journal, February 2017
- Denisov, Ilia G.; Sligar, Stephen G.
- Chemical Reviews, Vol. 117, Issue 6
Drug-Polymer Conjugates Coupled to a Peptidic Carrier
patent-application, August 2008
- Sinko, Patrick; Stein, Stanley; Gunaseelan, Simi
- US Patent Application 11/816317; 20080188399
Amplification of biotin-mediated targeting
patent-application, June 2006
- Russell-Jones, Gregory; Mcewan, John
- US Patent Application 10/535269; 20060127310
Structure, phase transitions and polymerizability of multilayers of some diacetylene monocarboxylic acids
journal, May 1980
- Lieser, Günter; Tieke, Bernd; Wegner, Gerhard
- Thin Solid Films, Vol. 68, Issue 1
Cell-free synthesis of a functional G protein-coupled receptor complexed with nanometer scale bilayer discs
journal, January 2011
- Yang, Jian-Ping; Cirico, Tatiana; Katzen, Federico
- BMC Biotechnology, Vol. 11, Issue 1
Design and Synthesis of a Library of BODIPY-Based Environmental Polarity Sensors Utilizing Photoinduced Electron-Transfer-Controlled Fluorescence ON/OFF Switching
journal, May 2007
- Sunahara, Hisato; Urano, Yasuteru; Kojima, Hirotatsu
- Journal of the American Chemical Society, Vol. 129, Issue 17
Functional consequences of lipid packing stress
journal, July 2000
- Bezrukov, Sergey M.
- Current Opinion in Colloid & Interface Science, Vol. 5, Issue 3-4
Small-angle X-ray and neutron scattering demonstrates that cell-free expression produces properly formed disc-shaped nanolipoprotein particles: SANS/SAXS Studies of NLP Assembly Methods
journal, February 2018
- Cleveland, Thomas E.; He, Wei; Evans, Angela C.
- Protein Science, Vol. 27, Issue 3
MOMP from Campylobacter jejuni Is a Trimer of 18-Stranded β-Barrel Monomers with a Ca 2+ Ion Bound at the Constriction Zone
journal, November 2016
- Ferrara, Luana G. M.; Wallat, Gregor D.; Moynié, Lucile
- Journal of Molecular Biology, Vol. 428, Issue 22
Membrane scaffold proteins
patent, September 2009
- Sligar, Stephen G.; Bayburt, Timothy H.; Schuler, Mary A.
- US Patent Document 7,592,008
Apolipoprotein A-I Mimics
patent-application, November 2016
- Dasseux, Jean-Louis; Schwendeman, Anna Shenderova; Zhu, Lingyu
- US Patent Application 15/207158; 20160324923
On the conformational, physical properties and functions of polyunsaturated acyl chains
journal, August 1991
- Rabinovich, Alexander L.; Ripatti, Pauli O.
- Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, Vol. 1085, Issue 1
Apolipoprotein A-I mimetic peptide helix number and helix linker influence potentially anti-atherogenic properties
journal, March 2008
- Wool, Geoffrey D.; Reardon, Catherine A.; Getz, Godfrey S.
- Journal of Lipid Research, Vol. 49, Issue 6
Clinical validation of the “in silico” prediction of immunogenicity of a human recombinant therapeutic protein
journal, July 2007
- Koren, E.; De Groot, A. S.; Jawa, V.
- Clinical Immunology, Vol. 124, Issue 1
Human Recombinant Apolipoprotein E-Enriched Liposomes Can Mimic Low-Density Lipoproteins as Carriers for the Site-Specific Delivery of Antitumor Agents
journal, September 1997
- Rensen, Patrick C. N.; Schiffelers, Raymond M.; Versluis, A. Jenny
- Molecular Pharmacology, Vol. 52, Issue 3
Nanotechnology and aptamers: applications in drug delivery
journal, August 2008
- Levy-Nissenbaum, Etgar; Radovic-Moreno, Aleksandar F.; Wang, Andrew Z.
- Trends in Biotechnology, Vol. 26, Issue 8
Nanobiotechnology applications of reconstituted high density lipoprotein
journal, January 2010
- Ryan, Robert O.
- Journal of Nanobiotechnology, Vol. 8, Issue 1
Electrochemical Flow-Cell for Hydrogen Production and Nicotinamide Dependent Target Reduction, and Related Methods and Systems
patent-application, February 2019
- Hoeprich, Jr., Paul D.; Kim, SAngil
- US Patent Application 16/167384; 20190055658
Comparison of the nine polymorphic membrane proteins of Chlamydia trachomatis for their ability to induce protective immune responses in mice against a C. muridarum challenge
journal, May 2017
- Pal, Sukumar; Favaroni, Alison; Tifrea, Delia F.
- Vaccine, Vol. 35, Issue 19
Lipophilic drug delivery vehicle and methods of use thereof
patent, November 2010
- Ryan, Robert; Oda, Michael N.
- US Patent Document 7,824,709
Nanolipoprotein Particles and Related Compositions Methods and System for Loading RNA
patent-application, November 2018
- Kamrud, Kurt I.; Wang, Nathaniel S.; Felderman, Martina
- US Patent Application 15/969311; 20180318218
Polymerized Lipid Bilayers on a Solid Substrate: Morphologies and Obstruction of Lateral Diffusion
journal, December 2008
- Okazaki, Takashi; Inaba, Takehiko; Tatsu, Yoshiro
- Langmuir, Vol. 25, Issue 1
EMAN2: An extensible image processing suite for electron microscopy
journal, January 2007
- Tang, Guang; Peng, Liwei; Baldwin, Philip R.
- Journal of Structural Biology, Vol. 157, Issue 1
Synthesis of many different types of organic small molecules using one automated process
journal, March 2015
- Li, J.; Ballmer, S. G.; Gillis, E. P.
- Science, Vol. 347, Issue 6227
Cell-free Co-expression of Functional Membrane Proteins and Apolipoprotein, Forming Soluble Nanolipoprotein Particles
journal, July 2008
- Cappuccio, Jenny A.; Blanchette, Craig D.; Sulchek, Todd A.
- Molecular & Cellular Proteomics, Vol. 7, Issue 11
Immunostimulatory Nanoparticles and Related Compositions, Methods and Systems
patent-application, April 2010
- Hoeprich, Paul D.; Fischer, Nicholas O.; Blanchette, Craig
- US Patent Application 12/604362; 20100092567
MOMP telonanoparticles, and related compositions, methods and systems
patent-application, February 2020
- Coleman, Matthew A.; Fischer, Nicholas O.; Rasley, Amy
- US Patent Application 16/609420; 20200046848
Membrane scaffold proteins
patent, April 2010
- Sligar, Stephen G.; Bayburt, Timothy H.
- US Patent Document 7,691,414
Method for forming proteoliposome and method for forming giant proteoliposome
patent, December 1994
- Kanno, Tsunehiro; Ohyama, Junji; Sakuranaga, Masanori
- US Patent Document 5,374,715
Phospholipid polymers—Synthesis and spectral characteristics
journal, October 1980
- Johnston, David Samuel; Sanghera, Sukhpal; Pons, Miquel
- Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 602, Issue 1
Two-Dimensional Polymerization of Lipid Bilayers: Rate of Polymerization of Acryloyl and Methacryloyl Lipids
journal, March 1994
- Lei, Junting; O'Brien, David F.
- Macromolecules, Vol. 27, Issue 6
Submersible Online Oxygen Removal System Coupled to an in Situ Voltammetric Probe for Trace Element Monitoring in Freshwater
journal, August 2000
- Tercier-Waeber, M. -L.; Buffle, J.
- Environmental Science & Technology, Vol. 34, Issue 18
Structural and Functional Analyses of the Major Outer Membrane Protein of Chlamydia trachomatis
journal, June 2007
- Sun, G.; Pal, S.; Sarcon, A. K.
- Journal of Bacteriology, Vol. 189, Issue 17
The effectiveness of styrene-maleic acid (SMA) copolymers for solubilisation of integral membrane proteins from SMA-accessible and SMA-resistant membranes
journal, October 2017
- Swainsbury, David J. K.; Scheidelaar, Stefan; Foster, Nicholas
- Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1859, Issue 10
Polymerization of diacetylenes in multilayers
journal, June 1979
- Tieke, B.; Lieser, G.; Wegner, G.
- Journal of Polymer Science: Polymer Chemistry Edition, Vol. 17, Issue 6
Phospholipid phase transitions in homogeneous nanometer scale bilayer discs
journal, December 2003
- Shaw, Andrew W.; McLean, Mark A.; Sligar, Stephen G.
- FEBS Letters, Vol. 556, Issue 1-3, p. 260-264
Prediction of the membrane-spanning β-strands of the major outer membrane protein of Chlamydia
journal, July 2002
- Rodríguez-Marañón, María José; Bush, Robin M.; Peterson, Ellena M.
- Protein Science, Vol. 11, Issue 7
An ethanol/ether soluble apoprotein from rat lung surfactant augments liposome uptake by isolated granular pneumocytes.
journal, September 1984
- Claypool, W. D.; Wang, D. L.; Chander, A.
- Journal of Clinical Investigation, Vol. 74, Issue 3
Minimum Amino Acid Residues of an α-Helical Peptide Leading to Lipid Nanodisc Formation
journal, January 2014
- Imura, Tomohiro; Tsukui, Yohei; Sakai, Kenichi
- Journal of Oleo Science, Vol. 63, Issue 11
Nanodiscs Allow Phage Display Selection for Ligands to Non-Linear Epitopes on Membrane Proteins
journal, September 2013
- Pavlidou, Marina; Hänel, Karen; Möckel, Luis
- PLoS ONE, Vol. 8, Issue 9
A New Method for Measuring Edge Tensions and Stability of Lipid Bilayers: Effect of Membrane Composition
journal, November 2010
- Portet, Thomas; Dimova, Rumiana
- Biophysical Journal, Vol. 99, Issue 10
Biomembrane surfaces as models for polymer design: the potential for haemocompatibility
journal, May 1984
- Hayward, James A.; Chapman, Dennis
- Biomaterials, Vol. 5, Issue 3
Membrane protein structural biology: the high throughput challenge
journal, April 2003
- Loll, Patrick J.
- Journal of Structural Biology, Vol. 142, Issue 1
Immunization with the Chlamydia trachomatis Mouse Pneumonitis Major Outer Membrane Protein Can Elicit a Protective Immune Response against a Genital Challenge
journal, October 2001
- Pal, S.; Theodor, I.; Peterson, E. M.
- Infection and Immunity, Vol. 69, Issue 10
Nanomechanical detection of cholera toxin using microcantilevers functionalized with ganglioside nanodiscs
journal, October 2010
- Tark, Soo-Hyun; Das, Aditi; Sligar, Stephen
- Nanotechnology, Vol. 21, Issue 43
Solubilisation of methane monooxygenase from Methylococcus capsulatus (Bath)
journal, July 1989
- Smith, D. Drummond S.; Dalton, Howard
- European Journal of Biochemistry, Vol. 182, Issue 3
Kinetic Analysis of His-Tagged Protein Binding to Nickel-Chelating Nanolipoprotein Particles
journal, July 2010
- Blanchette, Craig D.; Fischer, Nicholas O.; Corzett, Michele
- Bioconjugate Chemistry, Vol. 21, Issue 7
Application on Monoolein as a New Helper Lipid in Transfection
patent-application, July 2011
- Cunha Dias Real Oliveira, Maria Elisabete; Gomes Coutinho, Paulo Jose; Fernandez Pereira Coutinho, Olga MAria
- US Patent Application 13/059950; 20110178164
The contribution of macrophyte-derived organic matter to microbial biomass in salt-marsh sediments: Stable carbon isotope analysis of microbial biomarkers
journal, March 1999
- Boschker, H. T. S.; de Brouwer, J. F. C.; Cappenberg, T. E.
- Limnology and Oceanography, Vol. 44, Issue 2
Protection against an intranasal challenge by vaccines formulated with native and recombinant preparations of the Chlamydia trachomatis major outer membrane protein
journal, August 2009
- Sun, Guifeng; Pal, Sukumar; Weiland, Joseph
- Vaccine, Vol. 27, Issue 36
Mechanisms for the incorporation of proteins in membranes and organelles.
journal, January 1982
- Sabatini, D. D.; Kreibich, G.; Morimoto, T.
- Journal of Cell Biology, Vol. 92, Issue 1
Synthetic amphipathic helical peptides that mimic apolipoprotein A-I in clearing cellular cholesterol.
journal, October 1994
- Mendez, A. J.; Anantharamaiah, G. M.; Segrest, J. P.
- Journal of Clinical Investigation, Vol. 94, Issue 4
Molecules That Mimic Apolipoprotein A-I: Potential Agents for Treating Atherosclerosis
journal, October 2013
- Leman, Luke J.; Maryanoff, Bruce E.; Ghadiri, M. Reza
- Journal of Medicinal Chemistry, Vol. 57, Issue 6
Outer membrane proteins preferentially load MHC class II peptides: Implications for a Chlamydia trachomatis T cell vaccine
journal, April 2015
- Karunakaran, Karuna P.; Yu, Hong; Jiang, Xiaozhou
- Vaccine, Vol. 33, Issue 18
Helical and tubular microstructures formed by polymerizable phosphatidylcholines
journal, September 1987
- Georger, Jacque H.; Singh, Alok; Price, Ronald R.
- Journal of the American Chemical Society, Vol. 109, Issue 20
Nanocarriers for Drug Delivery
patent-application, November 2011
- Lam, Kit; Luo, Juntao
- US Patent Application 13/120140; 20110286915
Effect of Chain Length and Unsaturation on Elasticity of Lipid Bilayers
journal, July 2000
- Rawicz, W.; Olbrich, K. C.; McIntosh, T.
- Biophysical Journal, Vol. 79, Issue 1
Novel targeted delivery systems for bioactive agents
patent-application, April 2002
- Unger, Evan; Matsunaga, Terry Onichi; Ramaswami, Varadarajan
- US Patent Application 09/912609; 20020041898
Treatment of patients with cardiovascular disease with L-4F, an apo-A1 mimetic, did not improve select biomarkers of HDL function
journal, February 2011
- Watson, Catherine E.; Weissbach, Nicole; Kjems, Lise
- Journal of Lipid Research, Vol. 52, Issue 2
Nanodisks: hydrophobic drug delivery vehicles
journal, March 2008
- Ryan, Robert O.
- Expert Opinion on Drug Delivery, Vol. 5, Issue 3
A biomimetic nanovector-mediated targeted cholesterol-conjugated siRNA delivery for tumor gene therapy
journal, December 2012
- Ding, Yang; Wang, Wei; Feng, Meiqing
- Biomaterials, Vol. 33, Issue 34
Assembly of anthrax toxin pore: Lethal-factor complexes into lipid nanodiscs: Assembly of Anthrax Toxin Pore: Lethal Factor Complexes
journal, February 2013
- Akkaladevi, N.; Hinton-Chollet, L.; Katayama, H.
- Protein Science, Vol. 22, Issue 4
Functional capsule membranes. Part 31. Polymerizable lipid-corked capsule membranes. Polymerization at different positions of corking lipid bilayers on the capsule and effect of polymerization on permeation behavior
journal, April 1988
- Okahata, Yoshio.; Ariga, Katsuhiko.; Seki, Takahiro.
- Journal of the American Chemical Society, Vol. 110, Issue 8
Safety, pharmacokinetics, and pharmacodynamics of oral apoA-I mimetic peptide D-4F in high-risk cardiovascular patients
journal, June 2008
- Bloedon, LeAnne T.; Dunbar, Richard; Duffy, Danielle
- Journal of Lipid Research, Vol. 49, Issue 6
Immunogenicity of a chimeric peptide corresponding to T helper and B cell epitopes of the Chlamydia trachomatis major outer membrane protein.
journal, January 1992
- Su, H.; Caldwell, H. D.
- Journal of Experimental Medicine, Vol. 175, Issue 1
A Novel Procedure for the Synthesis of Libraries Containing Small Organic Molecules
journal, November 1994
- Carell, Thomas; Wintner, Edward A.; Bashir-Hashemi, A.
- Angewandte Chemie International Edition in English, Vol. 33, Issue 20
Mapping antigenic domains expressed by Chlamydia trachomatis major outer membrane protein genes.
journal, June 1988
- Baehr, W.; Zhang, Y. X.; Joseph, T.
- Proceedings of the National Academy of Sciences, Vol. 85, Issue 11
Preparation of pharmaceutical compositions
patent, July 2003
- Leigh, Steven; Leigh, Mathew Louis Steven
- US Patent Document 6,599,527
Multi-Domain Amphipathic Helical Peptides and Methods of Their Use
patent-application, June 2012
- Remaly, Alan T.; Demosky, Stephe J.; Stonik, John A.
- US Patent Application 13/407132; 20120148642
Oxpholipin 11D: An Anti-Inflammatory Peptide That Binds Cholesterol and Oxidized Phospholipids
journal, April 2010
- Ruchala, Piotr; Navab, Mohamad; Jung, Chun-Ling
- PLoS ONE, Vol. 5, Issue 4
Vaccination with the Chlamydia trachomatis Major Outer Membrane Protein Can Elicit an Immune Response as Protective as That Resulting from Inoculation with Live Bacteria
journal, November 2005
- Pal, S.; Peterson, E. M.; de la Maza, L. M.
- Infection and Immunity, Vol. 73, Issue 12
Preparation and Characterization of Reconstituted Lipid–Synthetic Polymer Discoidal Particles
journal, November 2015
- Tanaka, Masafumi; Hosotani, Akira; Tachibana, Yuka
- Langmuir, Vol. 31, Issue 46
Lysine-Based Polymeric Linkers
patent-application, August 2009
- Zhao, Hong; Reddy, Prasanna
- US Patent Application 12/402980; 20090203706
Amphipols stabilize the Chlamydia major outer membrane protein and enhance its protective ability as a vaccine
journal, June 2011
- Tifrea, Delia F.; Sun, Guifeng; Pal, Sukumar
- Vaccine, Vol. 29, Issue 28
Isolation of recombinant fragments of the major outer-membrane protein of Chlamydia trachomatis: their potential as subunit vaccines
journal, October 1990
- Conlan, J. W.; Ferris, S.; Clarke, I. N.
- Journal of General Microbiology, Vol. 136, Issue 10
Apolipoprotein nanodiscs with telodendrimer
patent, May 2017
- Luo, Juntao; He, Wei; Lam, Kit S.
- US Patent Document 9,644,038
Immunoproteomic Discovery of Novel T Cell Antigens from the Obligate Intracellular Pathogen Chlamydia
journal, February 2008
- Karunakaran, Karuna P.; Rey-Ladino, Jose; Stoynov, Nikolay
- The Journal of Immunology, Vol. 180, Issue 4
The Fluid Mosaic Model of the Structure of Cell Membranes
journal, February 1972
- Singer, S. J.; Nicolson, G. L.
- Science, Vol. 175, Issue 4023
Lipid Cross-Linking of Nanolipoprotein Particles Substantially Enhances Serum Stability and Cellular Uptake
journal, August 2016
- Gilmore, Sean F.; Blanchette, Craig D.; Scharadin, Tiffany M.
- ACS Applied Materials & Interfaces, Vol. 8, Issue 32
A Novel Apolipoprotein C-II Mimetic Peptide That Activates Lipoprotein Lipase and Decreases Serum Triglycerides in Apolipoprotein E–Knockout Mice
journal, November 2014
- Amar, Marcelo J. A.; Sakurai, Toshihiro; Sakurai-Ikuta, Akiko
- Journal of Pharmacology and Experimental Therapeutics, Vol. 352, Issue 2
Methods and Systems for Producing Nanolipoprotein Particles
patent-application, March 2019
- Coleman, Matthew A.; Hoeprich, JR., Paul D.; Segelke, Brent W.
- US Patent Application 16/159189; 20190094230
PmpG 303-311 , a Protective Vaccine Epitope That Elicits Persistent Cellular Immune Responses in Chlamydia muridarum-Immune Mice
journal, June 2012
- Johnson, Raymond M.; Yu, Hong; Kerr, Micah S.
- Infection and Immunity, Vol. 80, Issue 6
Isolation of Monodisperse Nanodisc-Reconstituted Membrane Proteins Using Free Flow Electrophoresis
journal, March 2013
- Justesen, Bo Højen; Laursen, Tomas; Weber, Gerhard
- Analytical Chemistry, Vol. 85, Issue 7
Polymerized phosphatidyl choline vesicles. Stabilized and controllable time-release carriers
journal, July 1981
- Regen, Steven L.; Singh, Alok; Oehme, Günther
- Biochemical and Biophysical Research Communications, Vol. 101, Issue 1
Isolated Phospholipid-Protein Particles
patent-application, October 2008
- Katzen, Federico; Fletcher, Julia; Kudlicki, Wieslaw
- US Patent Application 12/040798; 20080248565
Truncated apolipoprotein B-containing lipoprotein particles for delivery of compounds to tissues or cells
patent-application, January 2003
- Shelness, Gregory S.
- US Patent Application 09/885894; 20030008014
Lipidated Glycosaminoglycan Particles for the Delivery of Nucleic Acids
patent-application, May 2015
- Peer, Dan; Alpert, Evgenia
- US Patent Application 14/395198; 20150140108
Studies of synthetic peptide analogs of the amphipathic helix. Structure of complexes with dimyristoyl phosphatidylcholine.
journal, August 1985
- Anantharamaiah, G. M.; Jones, J. L.; Brouillette, C. G.
- Journal of Biological Chemistry, Vol. 260, Issue 18
Modulation of human erg K+ channel gating by activation of a G protein-coupled receptor and protein kinase C
journal, September 1998
- Barros, Francisco; Gómez-Varela, David; Viloria, Cristina G.
- The Journal of Physiology, Vol. 511, Issue 2, p. 333-346
Preparation, Characterizations, and In Vitro Metabolic Processes of Paclitaxel-Loaded Discoidal Recombinant High-Density Lipoproteins
journal, August 2012
- Jia, Junting; Xiao, Yan; Liu, Jianping
- Journal of Pharmaceutical Sciences, Vol. 101, Issue 8
A Simple Construction of a Bile Acid Based Dendritic Light Harvesting System
journal, June 2005
- Vijayalakshmi, N.; Maitra, Uday
- Organic Letters, Vol. 7, Issue 13, p. 2727-2730
Developable Bottom Antireflective Coating Compositions Especially Suitable for Ion Implant Applications
patent-application, July 2012
- Huang, Wu-Song; Vyklicky, Libor; Rao, Pushkara
- US Patent Application 13/425,903; 2012/0178029 Al
The use of nanolipoprotein particles to enhance the immunostimulatory properties of innate immune agonists against lethal influenza challenge
journal, December 2013
- Weilhammer, Dina R.; Blanchette, Craig D.; Fischer, Nicholas O.
- Biomaterials, Vol. 34, Issue 38
Identification and cellular localization of human PFTAIRE1
journal, April 2001
- Yang, Tao; Chen, Jiang-ye
- Gene, Vol. 267, Issue 2
Nanolipoprotein Particles Comprising a Natural Rubber Biosynthetic Enzyme Complex and Related Products, Methods and Systems
patent-application, September 2014
- Hoeprich, Paul D.
- US Patent Application 14/199973; 20140273142
Fluorescence Correlation Spectroscopy: Past, Present, Future
journal, December 2011
- Elson, Elliot L.
- Biophysical Journal, Vol. 101, Issue 12
Phase Separation of Lipid Microdomains Controlled by Polymerized Lipid Bilayer Matrices
journal, December 2009
- Okazaki, Takashi; Tatsu, Yoshiro; Morigaki, Kenichi
- Langmuir, Vol. 26, Issue 6
Confinement in Nanodiscs Anisotropically Modifies Lipid Bilayer Elastic Properties
journal, July 2020
- Schachter, Itay; Allolio, Christoph; Khelashvili, George
- The Journal of Physical Chemistry B, Vol. 124, Issue 33
Enzyme-Catalyzed O 2 Removal System for Electrochemical Analysis under Ambient Air: Application in an Amperometric Nitrate Biosensor
journal, February 2012
- Plumeré, Nicolas; Henig, Jörg; Campbell, Wilbur H.
- Analytical Chemistry, Vol. 84, Issue 5
A self-assembling nanoparticle for paclitaxel delivery in ovarian cancer
journal, October 2009
- Xiao, Kai; Luo, Juntao; Fowler, Wiley L.
- Biomaterials, Vol. 30, Issue 30, p. 6006-6016
Expression and Association of the Yersinia pestis Translocon Proteins, YopB and YopD, Are Facilitated by Nanolipoprotein Particles
journal, March 2016
- Coleman, Matthew A.; Cappuccio, Jenny A.; Blanchette, Craig D.
- PLOS ONE, Vol. 11, Issue 3
Model Studies of Membrane Disruption by Photogenerated Oxidative Assault
journal, April 2010
- Howland, Michael C.; Parikh, Atul N.
- The Journal of Physical Chemistry B, Vol. 114, Issue 19
Molecular cloning of a gene encoding the histamine H2 receptor.
journal, January 1991
- Gantz, I.; Schaffer, M.; DelValle, J.
- Proceedings of the National Academy of Sciences, Vol. 88, Issue 2
Thermotropic Phase Transition in Soluble Nanoscale Lipid Bilayers
journal, August 2005
- Denisov, Ilia G.; McLean, Mark A.; Shaw, Andrew W.
- The Journal of Physical Chemistry B, Vol. 109, Issue 32
Tissue Factor Compositions and Methods
patent-application, April 2006
- Morrissey, Janes H.; Pureza, Vincent S.; Sligar, Stephen G.
- US Patent Application 11/259,950; 2006/0088524 Al
A high-throughput shotgun mutagenesis approach to mapping B-cell antibody epitopes
journal, July 2014
- Davidson, Edgar; Doranz, Benjamin J.
- Immunology, Vol. 143, Issue 1
Binding of apolipoprotein A-I model peptides to lipid bilayers. Measurement of binding isotherms and peptide-lipid headgroup interactions.
journal, September 1994
- Spuhler, P.; Anantharamaiah, G. M.; Segrest, J. P.
- Journal of Biological Chemistry, Vol. 269, Issue 39
Structure and aggregation in dilate solution of surface active agents
journal, February 1953
- Klevens, H. B.
- Journal of the American Oil Chemists' Society, Vol. 30, Issue 2
Nanolipoprotein Particles and Related Compositions Methods and Systems for Improved Drug Loading
patent-application, October 2019
- Blanchette, Craig D.; Fischer, Nicholas; Gilmore, Sean Patrick
- US Patent Application 16/082924; 20190307692
Antimicrobial Activities of Amine- and Guanidine-Functionalized Cholic Acid Derivatives
journal, June 1999
- Li, Chunhong; Lewis, Matthew R.; Gilbert, Amy B.
- Antimicrobial Agents and Chemotherapy, Vol. 43, Issue 6
Synthetic Apolipoproteins, and Related Compositions Methods and Systems for Nanolipoprotein Particles Formation
patent-application, July 2018
- Hoeprich, Jr., Paul D.; Camarero, Julio A.
- US Patent Application 15/744754; 20180186860
An apolipoprotein A-I mimetic dose-dependently increases the formation of preβ 1 HDL in human plasma
journal, December 2007
- Troutt, Jason S.; Alborn, William E.; Mosior, Marian K.
- Journal of Lipid Research, Vol. 49, Issue 3
Drug Delivery Systems: Entering the Mainstream
journal, March 2004
- Allen, T. M.
- Science, Vol. 303, Issue 5665
Engineering extended membrane scaffold proteins for self-assembly of soluble nanoscale lipid bilayers
journal, September 2010
- Grinkova, Y. V.; Denisov, I. G.; Sligar, S. G.
- Protein Engineering Design and Selection, Vol. 23, Issue 11
Noncovalent Attachment of NAD + Cofactor onto Carbon Nanotubes for Preparation of Integrated Dehydrogenase-Based Electrochemical Biosensors
journal, February 2010
- Zhou, Haojie; Zhang, Zipin; Yu, Ping
- Langmuir, Vol. 26, Issue 8
The dawning era of polymer therapeutics
journal, May 2003
- Duncan, Ruth
- Nature Reviews Drug Discovery, Vol. 2, Issue 5, p. 347-360
A new type of synthetic peptide library for identifying ligand-binding activity
journal, November 1991
- Lam, Kit S.; Salmon, Sydney E.; Hersh, Evan M.
- Nature, Vol. 354, Issue 6348
Solid‐state polymerization of diacetylenes
journal, November 1972
- Baughman, R. H.
- Journal of Applied Physics, Vol. 43, Issue 11