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Title: Solution target for cyclotron production of radiometals

Abstract

Methods of producing and isolating 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 13N, 52Mn, or 44Sc and solution targets for use in the methods are disclosed. The methods of producing 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 13N, 52Mn, or 44Sc include irradiating a closed target system with a proton beam. The system can include a solution target. The methods of producing isolated 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 52Mn, or 44Sc further include isolating 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 52Mn, or 44Sc by ion exchange chromatography. An example target includes a target body including a target cavity for receiving the target material; a housing defining a passageway for directing a particle beam at the target cavity; a target window for covering an opening of the target cavity; and a coolant gas flow path disposed in the passageway upstream of the target window.

Inventors:
; ;
Issue Date:
Research Org.:
Mayo Foundation for Medical Education and Research, Rochester, MN (United States); The Brigham and Women's Hospital, Boston, MA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1892677
Patent Number(s):
11266975
Application Number:
16/565,125
Assignee:
Mayo Foundation for Medical Education and Research (Rochester, MN); The Brigham and Women's Hospital, Inc. (Boston, MA)
Patent Classifications (CPCs):
B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01D - SEPARATION
B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY
DOE Contract Number:  
SC0008947
Resource Type:
Patent
Resource Relation:
Patent File Date: 09/09/2019
Country of Publication:
United States
Language:
English

Citation Formats

DeGrado, Timothy R., Pandey, Mukesh K., and Byrne, John. Solution target for cyclotron production of radiometals. United States: N. p., 2022. Web.
DeGrado, Timothy R., Pandey, Mukesh K., & Byrne, John. Solution target for cyclotron production of radiometals. United States.
DeGrado, Timothy R., Pandey, Mukesh K., and Byrne, John. Tue . "Solution target for cyclotron production of radiometals". United States. https://www.osti.gov/servlets/purl/1892677.
@article{osti_1892677,
title = {Solution target for cyclotron production of radiometals},
author = {DeGrado, Timothy R. and Pandey, Mukesh K. and Byrne, John},
abstractNote = {Methods of producing and isolating 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 13N, 52Mn, or 44Sc and solution targets for use in the methods are disclosed. The methods of producing 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 13N, 52Mn, or 44Sc include irradiating a closed target system with a proton beam. The system can include a solution target. The methods of producing isolated 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 52Mn, or 44Sc further include isolating 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 52Mn, or 44Sc by ion exchange chromatography. An example target includes a target body including a target cavity for receiving the target material; a housing defining a passageway for directing a particle beam at the target cavity; a target window for covering an opening of the target cavity; and a coolant gas flow path disposed in the passageway upstream of the target window.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2022},
month = {3}
}

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