Title: Nucleic acids encoding HIV-1 GP140 immunogens comprising modified NHR1 regions that stabilize pre-fusion conformations

Abstract

The present invention provides HIV-1 vaccine immunogens. Some of the immunogens contain a soluble gp140-derived protein that harbors a modified N-terminus of the HR1 region in gp41. Some of the immunogens contain an HIV-1 Env-derived trimer protein that is presented on a nanoparticle platform. The invention also provides methods of using the HIV-1 vaccine immunogens for eliciting an immune response or treating HIV infections.

Inventors:

Kong, Leopold; Wilson, Ian A.; De Val, Natalia; Ward, Andrew B.; Burton, Dennis; He, Linling; Zhu, Jiang

Issue Date:

Tue Feb 01 00:00:00 EST 2022

Research Org.:

Argonne National Laboratory (ANL), Argonne, IL (United States)

Sponsoring Org.:

USDOE; National Institutes of Health (NIH)

OSTI Identifier:

1892576

Patent Number(s):

11236134

Application Number:

16/780,495

Assignee:

The Scripps Research Institute (Village of La Jolla, CA)

Patent Classifications (CPCs):

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A61K2039/5258 - {Virus-like particles}
A61K2039/6031 - {Proteins}
A61K2039/645 - {Dendrimers
A61K39/12 - Viral antigens
A61K39/21 - Retroviridae, e.g. equine infectious anemia virus
A61K47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
A61K47/6929 - {the form being a nanoparticle, e.g. an immuno-nanoparticle}

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P31/18 - for HIV
A61P37/04 - Immunostimulants

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES

C07K14/005 - from viruses
C07K14/162 - {env, e.g. gp160, gp110/120, gp41, V3, peptid T, CD4-Binding site}
C07K2319/735 - containing a domain for self-assembly, e.g. a viral coat protein

C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES

C12N2740/16122 - New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
C12N2740/16134 - Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
C12N7/02 - Recovery or purification

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DOE Contract Number:  

AC02-06CH11357; AI084817; AI100663; AI110657; GM094586

Resource Type:

Patent

Resource Relation:

Patent File Date: 02/03/2020

Country of Publication:

United States

Language:

English